CHANGES IN THE SURFACE IL-6 RECEPTOR EXPRESSION OF DISTINCT IMMUNE CELLS IN PROGRESSION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Introduction: Mechanisms of immune response in COPD are still poorly understood, despite global challenge which this disorder presents to public medicine. The objective of this study was to evaluate IL-6R expression on the surface of immune cells in the course of COPD progression. Materials and meth...

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Autores principales:	T. I. Vitkina, Yu. K. Denisenko, K. A. Sidletskaya
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	chronic obstructive pulmonary disease remission il-6r cd126 classic signaling pro-inflammatory properties anti-inflammatory properties immune cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9d40656577df48778ee6716c06a2af02
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spelling	oai:doaj.org-article:9d40656577df48778ee6716c06a2af022021-11-18T08:03:46ZCHANGES IN THE SURFACE IL-6 RECEPTOR EXPRESSION OF DISTINCT IMMUNE CELLS IN PROGRESSION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE1563-06252313-741X10.15789/1563-0625-2017-2-191-196https://doaj.org/article/9d40656577df48778ee6716c06a2af022017-05-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1222https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIntroduction: Mechanisms of immune response in COPD are still poorly understood, despite global challenge which this disorder presents to public medicine. The objective of this study was to evaluate IL-6R expression on the surface of immune cells in the course of COPD progression. Materials and methods. The study included 112 patients with stable mild, moderate and severe COPD (spirometry classes 1,2, and 3). A control group included 32 healthy subjects. The COPD patients were in remission phase. Expression of IL-6R on the surface of T lymphocytes, T helper cells, monocytes and granulocytes was determined by flow cytometry. Results and Discussion. Progression of the disease was accompanied by increase in the relative amounts of CD126+ immunocompetent cells. The number of CD4+CD126+ cells was maximally increased at all stages of COPD. Moreover, the number of CD126+ granulocytes proved to be significantly increased with increasing severity of COPD. Hence, it may be assumed that T-helper cells and granulocytes are primary target cells for IL-6 anti-inflammatory action, which is mediated by classic signaling.T. I. VitkinaYu. K. DenisenkoK. A. SidletskayaSPb RAACIarticlechronic obstructive pulmonary diseaseremissionil-6rcd126classic signalingpro-inflammatory propertiesanti-inflammatory propertiesimmune cellsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 2, Pp 191-196 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic obstructive pulmonary disease remission il-6r cd126 classic signaling pro-inflammatory properties anti-inflammatory properties immune cells Immunologic diseases. Allergy RC581-607
spellingShingle	chronic obstructive pulmonary disease remission il-6r cd126 classic signaling pro-inflammatory properties anti-inflammatory properties immune cells Immunologic diseases. Allergy RC581-607 T. I. Vitkina Yu. K. Denisenko K. A. Sidletskaya CHANGES IN THE SURFACE IL-6 RECEPTOR EXPRESSION OF DISTINCT IMMUNE CELLS IN PROGRESSION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
description	Introduction: Mechanisms of immune response in COPD are still poorly understood, despite global challenge which this disorder presents to public medicine. The objective of this study was to evaluate IL-6R expression on the surface of immune cells in the course of COPD progression. Materials and methods. The study included 112 patients with stable mild, moderate and severe COPD (spirometry classes 1,2, and 3). A control group included 32 healthy subjects. The COPD patients were in remission phase. Expression of IL-6R on the surface of T lymphocytes, T helper cells, monocytes and granulocytes was determined by flow cytometry. Results and Discussion. Progression of the disease was accompanied by increase in the relative amounts of CD126+ immunocompetent cells. The number of CD4+CD126+ cells was maximally increased at all stages of COPD. Moreover, the number of CD126+ granulocytes proved to be significantly increased with increasing severity of COPD. Hence, it may be assumed that T-helper cells and granulocytes are primary target cells for IL-6 anti-inflammatory action, which is mediated by classic signaling.
format	article
author	T. I. Vitkina Yu. K. Denisenko K. A. Sidletskaya
author_facet	T. I. Vitkina Yu. K. Denisenko K. A. Sidletskaya
author_sort	T. I. Vitkina
title	CHANGES IN THE SURFACE IL-6 RECEPTOR EXPRESSION OF DISTINCT IMMUNE CELLS IN PROGRESSION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_short	CHANGES IN THE SURFACE IL-6 RECEPTOR EXPRESSION OF DISTINCT IMMUNE CELLS IN PROGRESSION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_full	CHANGES IN THE SURFACE IL-6 RECEPTOR EXPRESSION OF DISTINCT IMMUNE CELLS IN PROGRESSION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_fullStr	CHANGES IN THE SURFACE IL-6 RECEPTOR EXPRESSION OF DISTINCT IMMUNE CELLS IN PROGRESSION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_full_unstemmed	CHANGES IN THE SURFACE IL-6 RECEPTOR EXPRESSION OF DISTINCT IMMUNE CELLS IN PROGRESSION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
title_sort	changes in the surface il-6 receptor expression of distinct immune cells in progression of chronic obstructive pulmonary disease
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/9d40656577df48778ee6716c06a2af02
work_keys_str_mv	AT tivitkina changesinthesurfaceil6receptorexpressionofdistinctimmunecellsinprogressionofchronicobstructivepulmonarydisease AT yukdenisenko changesinthesurfaceil6receptorexpressionofdistinctimmunecellsinprogressionofchronicobstructivepulmonarydisease AT kasidletskaya changesinthesurfaceil6receptorexpressionofdistinctimmunecellsinprogressionofchronicobstructivepulmonarydisease
_version_	1718422369276526592

CHANGES IN THE SURFACE IL-6 RECEPTOR EXPRESSION OF DISTINCT IMMUNE CELLS IN PROGRESSION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

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