Withaferin A effectively targets soluble vimentin in the glaucoma filtration surgical model of fibrosis.

Withaferin A effectively targets soluble vimentin in the glaucoma filtration surgical model of fibrosis.

Withaferin A (WFA) is a natural product that binds to soluble forms of the type III intermediate filament (IF) vimentin. Currently, it is unknown under what pathophysiological contexts vimentin is druggable, as cytoskeltal vimentin-IFs are abundantly expressed. To investigate druggability of vimenti...

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Autores principales: Paola Bargagna-Mohan, Sunil P Deokule, Kyle Thompson, John Wizeman, Cidambi Srinivasan, Sunil Vooturi, Uday B Kompella, Royce Mohan
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/9d42ba520c0441daa78792964c03f0a7
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