Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry

Neoantigens determine anti-cancer immunoreactivity and are important functional targets for immunotherapy. Here, the authors use deep mass spectrometry to characterize neoepitopes from human melanoma tissue and show the presence of tumour-reactive T cells with specificity for selected neoantigens.

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Autores principales: Michal Bassani-Sternberg, Eva Bräunlein, Richard Klar, Thomas Engleitner, Pavel Sinitcyn, Stefan Audehm, Melanie Straub, Julia Weber, Julia Slotta-Huspenina, Katja Specht, Marc E. Martignoni, Angelika Werner, Rüdiger Hein, Dirk H. Busch, Christian Peschel, Roland Rad, Jürgen Cox, Matthias Mann, Angela M. Krackhardt
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/9d43ba6c8b234b1ab6f92d398fb3a892
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spelling oai:doaj.org-article:9d43ba6c8b234b1ab6f92d398fb3a8922021-12-02T16:57:03ZDirect identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry10.1038/ncomms134042041-1723https://doaj.org/article/9d43ba6c8b234b1ab6f92d398fb3a8922016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13404https://doaj.org/toc/2041-1723Neoantigens determine anti-cancer immunoreactivity and are important functional targets for immunotherapy. Here, the authors use deep mass spectrometry to characterize neoepitopes from human melanoma tissue and show the presence of tumour-reactive T cells with specificity for selected neoantigens.Michal Bassani-SternbergEva BräunleinRichard KlarThomas EngleitnerPavel SinitcynStefan AudehmMelanie StraubJulia WeberJulia Slotta-HuspeninaKatja SpechtMarc E. MartignoniAngelika WernerRüdiger HeinDirk H. BuschChristian PeschelRoland RadJürgen CoxMatthias MannAngela M. KrackhardtNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Michal Bassani-Sternberg
Eva Bräunlein
Richard Klar
Thomas Engleitner
Pavel Sinitcyn
Stefan Audehm
Melanie Straub
Julia Weber
Julia Slotta-Huspenina
Katja Specht
Marc E. Martignoni
Angelika Werner
Rüdiger Hein
Dirk H. Busch
Christian Peschel
Roland Rad
Jürgen Cox
Matthias Mann
Angela M. Krackhardt
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
description Neoantigens determine anti-cancer immunoreactivity and are important functional targets for immunotherapy. Here, the authors use deep mass spectrometry to characterize neoepitopes from human melanoma tissue and show the presence of tumour-reactive T cells with specificity for selected neoantigens.
format article
author Michal Bassani-Sternberg
Eva Bräunlein
Richard Klar
Thomas Engleitner
Pavel Sinitcyn
Stefan Audehm
Melanie Straub
Julia Weber
Julia Slotta-Huspenina
Katja Specht
Marc E. Martignoni
Angelika Werner
Rüdiger Hein
Dirk H. Busch
Christian Peschel
Roland Rad
Jürgen Cox
Matthias Mann
Angela M. Krackhardt
author_facet Michal Bassani-Sternberg
Eva Bräunlein
Richard Klar
Thomas Engleitner
Pavel Sinitcyn
Stefan Audehm
Melanie Straub
Julia Weber
Julia Slotta-Huspenina
Katja Specht
Marc E. Martignoni
Angelika Werner
Rüdiger Hein
Dirk H. Busch
Christian Peschel
Roland Rad
Jürgen Cox
Matthias Mann
Angela M. Krackhardt
author_sort Michal Bassani-Sternberg
title Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
title_short Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
title_full Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
title_fullStr Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
title_full_unstemmed Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
title_sort direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/9d43ba6c8b234b1ab6f92d398fb3a892
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