The New Old CD8+ T Cells in the Immune Paradox of Pregnancy
CD8+ T cells are the most frequent T cell population in the immune cell compartment at the feto-maternal interface. Due to their cytotoxic potential, the presence of CD8+ T cells in the immune privileged pregnant uterus has raised considerable interest. Here, we review our current understanding of C...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:9d44edc243a34bf0abfebf8a08ca13892021-11-16T06:43:42ZThe New Old CD8+ T Cells in the Immune Paradox of Pregnancy1664-322410.3389/fimmu.2021.765730https://doaj.org/article/9d44edc243a34bf0abfebf8a08ca13892021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.765730/fullhttps://doaj.org/toc/1664-3224CD8+ T cells are the most frequent T cell population in the immune cell compartment at the feto-maternal interface. Due to their cytotoxic potential, the presence of CD8+ T cells in the immune privileged pregnant uterus has raised considerable interest. Here, we review our current understanding of CD8+ T cell biology in the uterus of pregnant women and discuss this knowledge in relation to a recently published immune cell Atlas of human decidua. We describe how the expansion of CD8+ T cells with an effector memory phenotype often presenting markers of exhaustion is critical for a successful pregnancy, and host defense towards pathogens. Moreover, we review new evidence on the presence of long-lasting immunological memory to former pregnancies and discuss its impact on prospective pregnancy outcomes. The formation of fetal-specific memory CD8+ T cell subests in the uterus, in particular of tissue resident, and stem cell memory cells requires further investigation, but promises interesting results to come. Advancing the knowledge of CD8+ T cell biology in the pregnant uterus will be pivotal for understanding not only tissue-specific immune tolerance but also the etiology of complications during pregnancy, thus enabling preventive or therapeutic interventions in the future.Lilja HardardottirMaria Victoria BazzanoLaura GlauLuca GattinoniLuca GattinoniAngela KöningerEva TolosaMaria Emilia SolanoFrontiers Media S.A.articlefetal tolerancefeto-maternal interfacedecidual CD8+T cellsimmune toleraceImmune regulationpregnancyImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
fetal tolerance feto-maternal interface decidual CD8+T cells immune tolerace Immune regulation pregnancy Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
fetal tolerance feto-maternal interface decidual CD8+T cells immune tolerace Immune regulation pregnancy Immunologic diseases. Allergy RC581-607 Lilja Hardardottir Maria Victoria Bazzano Laura Glau Luca Gattinoni Luca Gattinoni Angela Köninger Eva Tolosa Maria Emilia Solano The New Old CD8+ T Cells in the Immune Paradox of Pregnancy |
| description |
CD8+ T cells are the most frequent T cell population in the immune cell compartment at the feto-maternal interface. Due to their cytotoxic potential, the presence of CD8+ T cells in the immune privileged pregnant uterus has raised considerable interest. Here, we review our current understanding of CD8+ T cell biology in the uterus of pregnant women and discuss this knowledge in relation to a recently published immune cell Atlas of human decidua. We describe how the expansion of CD8+ T cells with an effector memory phenotype often presenting markers of exhaustion is critical for a successful pregnancy, and host defense towards pathogens. Moreover, we review new evidence on the presence of long-lasting immunological memory to former pregnancies and discuss its impact on prospective pregnancy outcomes. The formation of fetal-specific memory CD8+ T cell subests in the uterus, in particular of tissue resident, and stem cell memory cells requires further investigation, but promises interesting results to come. Advancing the knowledge of CD8+ T cell biology in the pregnant uterus will be pivotal for understanding not only tissue-specific immune tolerance but also the etiology of complications during pregnancy, thus enabling preventive or therapeutic interventions in the future. |
| format |
article |
| author |
Lilja Hardardottir Maria Victoria Bazzano Laura Glau Luca Gattinoni Luca Gattinoni Angela Köninger Eva Tolosa Maria Emilia Solano |
| author_facet |
Lilja Hardardottir Maria Victoria Bazzano Laura Glau Luca Gattinoni Luca Gattinoni Angela Köninger Eva Tolosa Maria Emilia Solano |
| author_sort |
Lilja Hardardottir |
| title |
The New Old CD8+ T Cells in the Immune Paradox of Pregnancy |
| title_short |
The New Old CD8+ T Cells in the Immune Paradox of Pregnancy |
| title_full |
The New Old CD8+ T Cells in the Immune Paradox of Pregnancy |
| title_fullStr |
The New Old CD8+ T Cells in the Immune Paradox of Pregnancy |
| title_full_unstemmed |
The New Old CD8+ T Cells in the Immune Paradox of Pregnancy |
| title_sort |
new old cd8+ t cells in the immune paradox of pregnancy |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/9d44edc243a34bf0abfebf8a08ca1389 |
| work_keys_str_mv |
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