Reliability of quantitative transverse relaxation time mapping with $${\text{T}}_{{2}}$$ T 2 -prepared whole brain pCASL

Reliability of quantitative transverse relaxation time mapping with $${\text{T}}_{{2}}$$ T 2 -prepared whole brain pCASL

Abstract Arterial spin labeling (ASL) is increasingly applied for cerebral blood flow mapping, but $${\text{T}}_{{2}}$$ T 2 relaxation of the ASL signal magnetization is often ignored, although it may be clinically relevant. To investigate the extent, to which quantitative $${\text{T}}_{{2}}$$ T 2 v...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Martin Schidlowski, Rüdiger Stirnberg, Tony Stöcker, Theodor Rüber
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/9d4616f7f7d64d6ca8bc98f06b9dc77a
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:9d4616f7f7d64d6ca8bc98f06b9dc77a
record_format dspace
spelling oai:doaj.org-article:9d4616f7f7d64d6ca8bc98f06b9dc77a2021-12-02T15:10:32ZReliability of quantitative transverse relaxation time mapping with $${\text{T}}_{{2}}$$ T 2 -prepared whole brain pCASL10.1038/s41598-020-74680-y2045-2322https://doaj.org/article/9d4616f7f7d64d6ca8bc98f06b9dc77a2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-74680-yhttps://doaj.org/toc/2045-2322Abstract Arterial spin labeling (ASL) is increasingly applied for cerebral blood flow mapping, but $${\text{T}}_{{2}}$$ T 2 relaxation of the ASL signal magnetization is often ignored, although it may be clinically relevant. To investigate the extent, to which quantitative $${\text{T}}_{{2}}$$ T 2 values in gray matter (GM) obtained by pseudocontinuous ASL (pCASL) perfusion MRI can be reproduced, are reliable and a potential neuroscientific biomarker, a prospective study was performed with ten healthy volunteers (5F,28 ± 3y) at a 3 T scanner. A $${\text{T}}_{{2}}$$ T 2 -prepared pCASL sequence enabled the measurement of quantitative $${\text{T}}_{{2}}$$ T 2 and perfusion maps. $${\text{T}}_{{2}}$$ T 2 times were modeled per voxel and analyzed within four GM-regions-of-interest (ROI). The intraclass correlation coefficients (ICCs) of the quantified ASL- $${\text{T}}_{{2}}$$ T 2 varied across brain regions. When averaged across subjects and postlabeling delays (PLDs), the ICCs ranged from reasonable values in parietal regions (ICC = 0.56) to smaller values in frontal regions (ICC = 0.36). Corresponding subject-averaged within-subject coefficients of variation (WSCVs) showed good test–retest measurement precision ( $${\text{WSCV}}_{{{\text{PLD}}}} \le 0.14$$ WSCV PLD ≤ 0.14 for all PLDs), but more pronounced inter-subject variance. Reliability and precision of quantified ASL- $${\text{T}}_{{2}}$$ T 2 were region-, PLD- and subject-specific, showing fair to robust results in occipital, parietal and temporal ROIs. The results give rise to consider the method for future cerebral studies, where variable perfusion or altered $${\text{T}}_{{2}}$$ T 2 times are suspected.Martin SchidlowskiRüdiger StirnbergTony StöckerTheodor RüberNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Martin Schidlowski
Rüdiger Stirnberg
Tony Stöcker
Theodor Rüber
Reliability of quantitative transverse relaxation time mapping with $${\text{T}}_{{2}}$$ T 2 -prepared whole brain pCASL
description Abstract Arterial spin labeling (ASL) is increasingly applied for cerebral blood flow mapping, but $${\text{T}}_{{2}}$$ T 2 relaxation of the ASL signal magnetization is often ignored, although it may be clinically relevant. To investigate the extent, to which quantitative $${\text{T}}_{{2}}$$ T 2 values in gray matter (GM) obtained by pseudocontinuous ASL (pCASL) perfusion MRI can be reproduced, are reliable and a potential neuroscientific biomarker, a prospective study was performed with ten healthy volunteers (5F,28 ± 3y) at a 3 T scanner. A $${\text{T}}_{{2}}$$ T 2 -prepared pCASL sequence enabled the measurement of quantitative $${\text{T}}_{{2}}$$ T 2 and perfusion maps. $${\text{T}}_{{2}}$$ T 2 times were modeled per voxel and analyzed within four GM-regions-of-interest (ROI). The intraclass correlation coefficients (ICCs) of the quantified ASL- $${\text{T}}_{{2}}$$ T 2 varied across brain regions. When averaged across subjects and postlabeling delays (PLDs), the ICCs ranged from reasonable values in parietal regions (ICC = 0.56) to smaller values in frontal regions (ICC = 0.36). Corresponding subject-averaged within-subject coefficients of variation (WSCVs) showed good test–retest measurement precision ( $${\text{WSCV}}_{{{\text{PLD}}}} \le 0.14$$ WSCV PLD ≤ 0.14 for all PLDs), but more pronounced inter-subject variance. Reliability and precision of quantified ASL- $${\text{T}}_{{2}}$$ T 2 were region-, PLD- and subject-specific, showing fair to robust results in occipital, parietal and temporal ROIs. The results give rise to consider the method for future cerebral studies, where variable perfusion or altered $${\text{T}}_{{2}}$$ T 2 times are suspected.
format article
author Martin Schidlowski
Rüdiger Stirnberg
Tony Stöcker
Theodor Rüber
author_facet Martin Schidlowski
Rüdiger Stirnberg
Tony Stöcker
Theodor Rüber
author_sort Martin Schidlowski
title Reliability of quantitative transverse relaxation time mapping with $${\text{T}}_{{2}}$$ T 2 -prepared whole brain pCASL
title_short Reliability of quantitative transverse relaxation time mapping with $${\text{T}}_{{2}}$$ T 2 -prepared whole brain pCASL
title_full Reliability of quantitative transverse relaxation time mapping with $${\text{T}}_{{2}}$$ T 2 -prepared whole brain pCASL
title_fullStr Reliability of quantitative transverse relaxation time mapping with $${\text{T}}_{{2}}$$ T 2 -prepared whole brain pCASL
title_full_unstemmed Reliability of quantitative transverse relaxation time mapping with $${\text{T}}_{{2}}$$ T 2 -prepared whole brain pCASL
title_sort reliability of quantitative transverse relaxation time mapping with $${\text{t}}_{{2}}$$ t 2 -prepared whole brain pcasl
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/9d4616f7f7d64d6ca8bc98f06b9dc77a
work_keys_str_mv AT martinschidlowski reliabilityofquantitativetransverserelaxationtimemappingwithtextt2t2preparedwholebrainpcasl
AT rudigerstirnberg reliabilityofquantitativetransverserelaxationtimemappingwithtextt2t2preparedwholebrainpcasl
AT tonystocker reliabilityofquantitativetransverserelaxationtimemappingwithtextt2t2preparedwholebrainpcasl
AT theodorruber reliabilityofquantitativetransverserelaxationtimemappingwithtextt2t2preparedwholebrainpcasl
_version_ 1718387707949875200

Ejemplares similares