Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy

Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy

Ageing is associated with muscle atrophy. Here, the authors show that the secreted glycoprotein Dickkopf 3 promotes muscle atrophy by inducing nuclear import of beta-catenin, its association with FoxO3 and the consequent activation of the atrophy-related genes Atrogin1 and MuRF1.

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Autores principales: Jie Yin, Lele Yang, Yangli Xie, Yan Liu, Sheng Li, Wenjun Yang, Bo Xu, Hongbin Ji, Lianghua Ding, Kun Wang, Gang Li, Lin Chen, Ping Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/9d490d719f8547d6bbf241813f2ebf47
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spelling oai:doaj.org-article:9d490d719f8547d6bbf241813f2ebf472021-12-02T17:32:18ZDkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy10.1038/s41467-018-04038-62041-1723https://doaj.org/article/9d490d719f8547d6bbf241813f2ebf472018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04038-6https://doaj.org/toc/2041-1723Ageing is associated with muscle atrophy. Here, the authors show that the secreted glycoprotein Dickkopf 3 promotes muscle atrophy by inducing nuclear import of beta-catenin, its association with FoxO3 and the consequent activation of the atrophy-related genes Atrogin1 and MuRF1.Jie YinLele YangYangli XieYan LiuSheng LiWenjun YangBo XuHongbin JiLianghua DingKun WangGang LiLin ChenPing HuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jie Yin
Lele Yang
Yangli Xie
Yan Liu
Sheng Li
Wenjun Yang
Bo Xu
Hongbin Ji
Lianghua Ding
Kun Wang
Gang Li
Lin Chen
Ping Hu
Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy
description Ageing is associated with muscle atrophy. Here, the authors show that the secreted glycoprotein Dickkopf 3 promotes muscle atrophy by inducing nuclear import of beta-catenin, its association with FoxO3 and the consequent activation of the atrophy-related genes Atrogin1 and MuRF1.
format article
author Jie Yin
Lele Yang
Yangli Xie
Yan Liu
Sheng Li
Wenjun Yang
Bo Xu
Hongbin Ji
Lianghua Ding
Kun Wang
Gang Li
Lin Chen
Ping Hu
author_facet Jie Yin
Lele Yang
Yangli Xie
Yan Liu
Sheng Li
Wenjun Yang
Bo Xu
Hongbin Ji
Lianghua Ding
Kun Wang
Gang Li
Lin Chen
Ping Hu
author_sort Jie Yin
title Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy
title_short Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy
title_full Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy
title_fullStr Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy
title_full_unstemmed Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy
title_sort dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/9d490d719f8547d6bbf241813f2ebf47
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