Pre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies

Abstract Few prospective studies have evaluated the relation between fat-soluble vitamins and glioma risk. Using three cohorts—UK Biobank (UKB), Nurses’ Health Study (NHS), and Health Professionals Follow-Up Study (HPFS), we investigated associations of pre-diagnostic concentrations of fat-soluble v...

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Autores principales:	Yiyang Yue, Jordan H. Creed, David J. Cote, Meir J. Stampfer, Molin Wang, Øivind Midttun, Adrian McCann, Per Magne Ueland, Jeremy Furtado, Kathleen M. Egan, Stephanie A. Smith-Warner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9d4a7f32e2d74a76855b66350a9f433d
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spelling	oai:doaj.org-article:9d4a7f32e2d74a76855b66350a9f433d2021-12-02T13:40:51ZPre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies10.1038/s41598-021-88485-02045-2322https://doaj.org/article/9d4a7f32e2d74a76855b66350a9f433d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88485-0https://doaj.org/toc/2045-2322Abstract Few prospective studies have evaluated the relation between fat-soluble vitamins and glioma risk. Using three cohorts—UK Biobank (UKB), Nurses’ Health Study (NHS), and Health Professionals Follow-Up Study (HPFS), we investigated associations of pre-diagnostic concentrations of fat-soluble vitamins D, A, and E with incident glioma. In 346,785 participants (444 cases) in UKB, associations with vitamin D (25-hydroxyvitamin D [25(OH)D]) were evaluated by Cox proportional hazards regression. In NHS (52 cases, 104 controls) and HPFS (32 cases, 64 controls), associations with 25(OH)D, vitamin A (retinol), and vitamin E (α- and γ-tocopherol) were assessed using conditional logistic regression. Our results suggested plasma concentrations of 25(OH)D and retinol were not associated with glioma risk. Comparing the highest to lowest tertile, the multivariable hazard ratio (MVHR) for 25(OH)D was 0.87 (95% confidence interval [CI] 0.68–1.11) in UKB and the multivariable risk ratio (MVRR) was 0.97 (95% CI 0.51–1.85) in NHS and HPFS. In NHS and HPFS, the MVRR for the same comparison for retinol was 1.16 (95% CI 0.56–2.38). Nonsignificant associations were observed for α-tocopherol (MVRRtertile3vs1 = 0.61, 95% CI 0.29–1.32) and γ-tocopherol (MVRR tertile3vs1 = 1.30, 95% CI 0.63–2.69) that became stronger in 4-year lagged analyses. Further investigation is warranted on a potential association between α- and γ-tocopherol and glioma risk.Yiyang YueJordan H. CreedDavid J. CoteMeir J. StampferMolin WangØivind MidttunAdrian McCannPer Magne UelandJeremy FurtadoKathleen M. EganStephanie A. Smith-WarnerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yiyang Yue Jordan H. Creed David J. Cote Meir J. Stampfer Molin Wang Øivind Midttun Adrian McCann Per Magne Ueland Jeremy Furtado Kathleen M. Egan Stephanie A. Smith-Warner Pre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies
description	Abstract Few prospective studies have evaluated the relation between fat-soluble vitamins and glioma risk. Using three cohorts—UK Biobank (UKB), Nurses’ Health Study (NHS), and Health Professionals Follow-Up Study (HPFS), we investigated associations of pre-diagnostic concentrations of fat-soluble vitamins D, A, and E with incident glioma. In 346,785 participants (444 cases) in UKB, associations with vitamin D (25-hydroxyvitamin D [25(OH)D]) were evaluated by Cox proportional hazards regression. In NHS (52 cases, 104 controls) and HPFS (32 cases, 64 controls), associations with 25(OH)D, vitamin A (retinol), and vitamin E (α- and γ-tocopherol) were assessed using conditional logistic regression. Our results suggested plasma concentrations of 25(OH)D and retinol were not associated with glioma risk. Comparing the highest to lowest tertile, the multivariable hazard ratio (MVHR) for 25(OH)D was 0.87 (95% confidence interval [CI] 0.68–1.11) in UKB and the multivariable risk ratio (MVRR) was 0.97 (95% CI 0.51–1.85) in NHS and HPFS. In NHS and HPFS, the MVRR for the same comparison for retinol was 1.16 (95% CI 0.56–2.38). Nonsignificant associations were observed for α-tocopherol (MVRRtertile3vs1 = 0.61, 95% CI 0.29–1.32) and γ-tocopherol (MVRR tertile3vs1 = 1.30, 95% CI 0.63–2.69) that became stronger in 4-year lagged analyses. Further investigation is warranted on a potential association between α- and γ-tocopherol and glioma risk.
format	article
author	Yiyang Yue Jordan H. Creed David J. Cote Meir J. Stampfer Molin Wang Øivind Midttun Adrian McCann Per Magne Ueland Jeremy Furtado Kathleen M. Egan Stephanie A. Smith-Warner
author_facet	Yiyang Yue Jordan H. Creed David J. Cote Meir J. Stampfer Molin Wang Øivind Midttun Adrian McCann Per Magne Ueland Jeremy Furtado Kathleen M. Egan Stephanie A. Smith-Warner
author_sort	Yiyang Yue
title	Pre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies
title_short	Pre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies
title_full	Pre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies
title_fullStr	Pre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies
title_full_unstemmed	Pre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies
title_sort	pre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9d4a7f32e2d74a76855b66350a9f433d
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Pre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies

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