Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Impaired glucagon secretion in patients with diabetes causes hypoglycemia. Here the authors show that therapeutic concentrations of insulin inhibit alpha-cell glucagon secretion by stimulating delta-cell insulin receptor and the release of somatostatin. Blocking somatostatin secretion or action amel...

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Autores principales: Elisa Vergari, Jakob G. Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford J. B. Briant, Margarita V. Chibalina, Fiona M. Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils J. G. Rorsman, Ioannis I. Spiliotis, Andrei Tarasov, Yanling Wu, Frances M. Ashcroft, Patrik Rorsman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/9d4aeee6ff1d49cdae2f6687f5fe8637
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Sumario:Impaired glucagon secretion in patients with diabetes causes hypoglycemia. Here the authors show that therapeutic concentrations of insulin inhibit alpha-cell glucagon secretion by stimulating delta-cell insulin receptor and the release of somatostatin. Blocking somatostatin secretion or action ameliorates this effect.

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