Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Impaired glucagon secretion in patients with diabetes causes hypoglycemia. Here the authors show that therapeutic concentrations of insulin inhibit alpha-cell glucagon secretion by stimulating delta-cell insulin receptor and the release of somatostatin. Blocking somatostatin secretion or action amel...

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Autores principales: Elisa Vergari, Jakob G. Knudsen, Reshma Ramracheya, Albert Salehi, Quan Zhang, Julie Adam, Ingrid Wernstedt Asterholm, Anna Benrick, Linford J. B. Briant, Margarita V. Chibalina, Fiona M. Gribble, Alexander Hamilton, Benoit Hastoy, Frank Reimann, Nils J. G. Rorsman, Ioannis I. Spiliotis, Andrei Tarasov, Yanling Wu, Frances M. Ashcroft, Patrik Rorsman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/9d4aeee6ff1d49cdae2f6687f5fe8637
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spelling oai:doaj.org-article:9d4aeee6ff1d49cdae2f6687f5fe86372021-12-02T16:51:00ZInsulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion10.1038/s41467-018-08193-82041-1723https://doaj.org/article/9d4aeee6ff1d49cdae2f6687f5fe86372019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08193-8https://doaj.org/toc/2041-1723Impaired glucagon secretion in patients with diabetes causes hypoglycemia. Here the authors show that therapeutic concentrations of insulin inhibit alpha-cell glucagon secretion by stimulating delta-cell insulin receptor and the release of somatostatin. Blocking somatostatin secretion or action ameliorates this effect.Elisa VergariJakob G. KnudsenReshma RamracheyaAlbert SalehiQuan ZhangJulie AdamIngrid Wernstedt AsterholmAnna BenrickLinford J. B. BriantMargarita V. ChibalinaFiona M. GribbleAlexander HamiltonBenoit HastoyFrank ReimannNils J. G. RorsmanIoannis I. SpiliotisAndrei TarasovYanling WuFrances M. AshcroftPatrik RorsmanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Elisa Vergari
Jakob G. Knudsen
Reshma Ramracheya
Albert Salehi
Quan Zhang
Julie Adam
Ingrid Wernstedt Asterholm
Anna Benrick
Linford J. B. Briant
Margarita V. Chibalina
Fiona M. Gribble
Alexander Hamilton
Benoit Hastoy
Frank Reimann
Nils J. G. Rorsman
Ioannis I. Spiliotis
Andrei Tarasov
Yanling Wu
Frances M. Ashcroft
Patrik Rorsman
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
description Impaired glucagon secretion in patients with diabetes causes hypoglycemia. Here the authors show that therapeutic concentrations of insulin inhibit alpha-cell glucagon secretion by stimulating delta-cell insulin receptor and the release of somatostatin. Blocking somatostatin secretion or action ameliorates this effect.
format article
author Elisa Vergari
Jakob G. Knudsen
Reshma Ramracheya
Albert Salehi
Quan Zhang
Julie Adam
Ingrid Wernstedt Asterholm
Anna Benrick
Linford J. B. Briant
Margarita V. Chibalina
Fiona M. Gribble
Alexander Hamilton
Benoit Hastoy
Frank Reimann
Nils J. G. Rorsman
Ioannis I. Spiliotis
Andrei Tarasov
Yanling Wu
Frances M. Ashcroft
Patrik Rorsman
author_facet Elisa Vergari
Jakob G. Knudsen
Reshma Ramracheya
Albert Salehi
Quan Zhang
Julie Adam
Ingrid Wernstedt Asterholm
Anna Benrick
Linford J. B. Briant
Margarita V. Chibalina
Fiona M. Gribble
Alexander Hamilton
Benoit Hastoy
Frank Reimann
Nils J. G. Rorsman
Ioannis I. Spiliotis
Andrei Tarasov
Yanling Wu
Frances M. Ashcroft
Patrik Rorsman
author_sort Elisa Vergari
title Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
title_short Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
title_full Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
title_fullStr Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
title_full_unstemmed Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
title_sort insulin inhibits glucagon release by sglt2-induced stimulation of somatostatin secretion
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/9d4aeee6ff1d49cdae2f6687f5fe8637
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