Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis
Asthma is a common allergic airway disease with significant inter-individual heterogeneity. Here, Olafsdottir et al. report a genome-wide meta-analysis of two large population-based cohorts to identify sequence variants that associate with asthma risk and perform follow-up functional analyses on a p...
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Nature Portfolio
2020
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oai:doaj.org-article:9d4c023806ed4deaa904e9b46d6dc5a92021-12-02T15:39:24ZEighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis10.1038/s41467-019-14144-82041-1723https://doaj.org/article/9d4c023806ed4deaa904e9b46d6dc5a92020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14144-8https://doaj.org/toc/2041-1723Asthma is a common allergic airway disease with significant inter-individual heterogeneity. Here, Olafsdottir et al. report a genome-wide meta-analysis of two large population-based cohorts to identify sequence variants that associate with asthma risk and perform follow-up functional analyses on a protective loss-of-function variant in TNFRSF8.Thorunn A. OlafsdottirFannar TheodorsKristbjorg BjarnadottirUnnur Steina BjornsdottirArna B. AgustsdottirOlafur A. StefanssonErna V. IvarsdottirJon K. SigurdssonStefania BenonisdottirGudmundur I. EyjolfssonDavid GislasonThorarinn GislasonSteinunn GuðmundsdóttirArnaldur GylfasonBjarni V. HalldorssonGisli H. HalldorssonThorhildur JuliusdottirAnna M. KristinsdottirDora LudviksdottirBjorn R. LudvikssonGisli MassonKristjan NorlandPall T. OnundarsonIsleifur OlafssonOlof SigurdardottirLilja StefansdottirGardar SveinbjornssonVinicius TraganteDaniel F. GudbjartssonGudmar ThorleifssonPatrick SulemUnnur ThorsteinsdottirGudmundur L. NorddahlIngileif JonsdottirKari StefanssonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020) |
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DOAJ |
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Science Q |
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Science Q Thorunn A. Olafsdottir Fannar Theodors Kristbjorg Bjarnadottir Unnur Steina Bjornsdottir Arna B. Agustsdottir Olafur A. Stefansson Erna V. Ivarsdottir Jon K. Sigurdsson Stefania Benonisdottir Gudmundur I. Eyjolfsson David Gislason Thorarinn Gislason Steinunn Guðmundsdóttir Arnaldur Gylfason Bjarni V. Halldorsson Gisli H. Halldorsson Thorhildur Juliusdottir Anna M. Kristinsdottir Dora Ludviksdottir Bjorn R. Ludviksson Gisli Masson Kristjan Norland Pall T. Onundarson Isleifur Olafsson Olof Sigurdardottir Lilja Stefansdottir Gardar Sveinbjornsson Vinicius Tragante Daniel F. Gudbjartsson Gudmar Thorleifsson Patrick Sulem Unnur Thorsteinsdottir Gudmundur L. Norddahl Ingileif Jonsdottir Kari Stefansson Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis |
| description |
Asthma is a common allergic airway disease with significant inter-individual heterogeneity. Here, Olafsdottir et al. report a genome-wide meta-analysis of two large population-based cohorts to identify sequence variants that associate with asthma risk and perform follow-up functional analyses on a protective loss-of-function variant in TNFRSF8. |
| format |
article |
| author |
Thorunn A. Olafsdottir Fannar Theodors Kristbjorg Bjarnadottir Unnur Steina Bjornsdottir Arna B. Agustsdottir Olafur A. Stefansson Erna V. Ivarsdottir Jon K. Sigurdsson Stefania Benonisdottir Gudmundur I. Eyjolfsson David Gislason Thorarinn Gislason Steinunn Guðmundsdóttir Arnaldur Gylfason Bjarni V. Halldorsson Gisli H. Halldorsson Thorhildur Juliusdottir Anna M. Kristinsdottir Dora Ludviksdottir Bjorn R. Ludviksson Gisli Masson Kristjan Norland Pall T. Onundarson Isleifur Olafsson Olof Sigurdardottir Lilja Stefansdottir Gardar Sveinbjornsson Vinicius Tragante Daniel F. Gudbjartsson Gudmar Thorleifsson Patrick Sulem Unnur Thorsteinsdottir Gudmundur L. Norddahl Ingileif Jonsdottir Kari Stefansson |
| author_facet |
Thorunn A. Olafsdottir Fannar Theodors Kristbjorg Bjarnadottir Unnur Steina Bjornsdottir Arna B. Agustsdottir Olafur A. Stefansson Erna V. Ivarsdottir Jon K. Sigurdsson Stefania Benonisdottir Gudmundur I. Eyjolfsson David Gislason Thorarinn Gislason Steinunn Guðmundsdóttir Arnaldur Gylfason Bjarni V. Halldorsson Gisli H. Halldorsson Thorhildur Juliusdottir Anna M. Kristinsdottir Dora Ludviksdottir Bjorn R. Ludviksson Gisli Masson Kristjan Norland Pall T. Onundarson Isleifur Olafsson Olof Sigurdardottir Lilja Stefansdottir Gardar Sveinbjornsson Vinicius Tragante Daniel F. Gudbjartsson Gudmar Thorleifsson Patrick Sulem Unnur Thorsteinsdottir Gudmundur L. Norddahl Ingileif Jonsdottir Kari Stefansson |
| author_sort |
Thorunn A. Olafsdottir |
| title |
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis |
| title_short |
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis |
| title_full |
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis |
| title_fullStr |
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis |
| title_full_unstemmed |
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis |
| title_sort |
eighty-eight variants highlight the role of t cell regulation and airway remodeling in asthma pathogenesis |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/9d4c023806ed4deaa904e9b46d6dc5a9 |
| work_keys_str_mv |
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