Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia

Current therapeutic strategies for vitamin D-induced hypercalcemia are poorly efficient. Here the authors identify a new interaction between the vitamin D receptor (VDR) and WBP4 controlling the subcellular localization of VDR and show that ZK168281, a VDR antagonist, enhances the interaction betwee...

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Autores principales:	Daniela Rovito, Anna Y. Belorusova, Sandra Chalhoub, Anna-Isavella Rerra, Elvire Guiot, Arnaud Molin, Agnès Linglart, Natacha Rochel, Gilles Laverny, Daniel Metzger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9d4c68e5bbb24aea82048d8c72e018ad
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spelling	oai:doaj.org-article:9d4c68e5bbb24aea82048d8c72e018ad2021-12-02T13:57:55ZCytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia10.1038/s41467-020-20069-42041-1723https://doaj.org/article/9d4c68e5bbb24aea82048d8c72e018ad2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20069-4https://doaj.org/toc/2041-1723Current therapeutic strategies for vitamin D-induced hypercalcemia are poorly efficient. Here the authors identify a new interaction between the vitamin D receptor (VDR) and WBP4 controlling the subcellular localization of VDR and show that ZK168281, a VDR antagonist, enhances the interaction between VDR and WBP4 blunting VDR signalling and normalizing calcium levels in vitamin D-intoxicated mice.Daniela RovitoAnna Y. BelorusovaSandra ChalhoubAnna-Isavella RerraElvire GuiotArnaud MolinAgnès LinglartNatacha RochelGilles LavernyDaniel MetzgerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniela Rovito Anna Y. Belorusova Sandra Chalhoub Anna-Isavella Rerra Elvire Guiot Arnaud Molin Agnès Linglart Natacha Rochel Gilles Laverny Daniel Metzger Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia
description	Current therapeutic strategies for vitamin D-induced hypercalcemia are poorly efficient. Here the authors identify a new interaction between the vitamin D receptor (VDR) and WBP4 controlling the subcellular localization of VDR and show that ZK168281, a VDR antagonist, enhances the interaction between VDR and WBP4 blunting VDR signalling and normalizing calcium levels in vitamin D-intoxicated mice.
format	article
author	Daniela Rovito Anna Y. Belorusova Sandra Chalhoub Anna-Isavella Rerra Elvire Guiot Arnaud Molin Agnès Linglart Natacha Rochel Gilles Laverny Daniel Metzger
author_facet	Daniela Rovito Anna Y. Belorusova Sandra Chalhoub Anna-Isavella Rerra Elvire Guiot Arnaud Molin Agnès Linglart Natacha Rochel Gilles Laverny Daniel Metzger
author_sort	Daniela Rovito
title	Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia
title_short	Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia
title_full	Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia
title_fullStr	Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia
title_full_unstemmed	Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia
title_sort	cytosolic sequestration of the vitamin d receptor as a therapeutic option for vitamin d-induced hypercalcemia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9d4c68e5bbb24aea82048d8c72e018ad
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Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia

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