Deep white matter in Huntington's disease.

White matter (WM) abnormalities have already been shown in presymptomatic (Pre-HD) and symptomatic HD subjects using Magnetic Resonance Imaging (MRI). In the present study, we examined the microstructure of the long-range large deep WM tracts by applying two different MRI approaches: Diffusion Tenso...

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Autores principales:	Owen Phillips, Ferdinando Squitieri, Cristina Sanchez-Castaneda, Francesca Elifani, Carlo Caltagirone, Umberto Sabatini, Margherita Di Paola
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9d4de6da340b4816bd5c1de732d518da
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id	oai:doaj.org-article:9d4de6da340b4816bd5c1de732d518da
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spelling	oai:doaj.org-article:9d4de6da340b4816bd5c1de732d518da2021-11-25T05:55:26ZDeep white matter in Huntington's disease.1932-620310.1371/journal.pone.0109676https://doaj.org/article/9d4de6da340b4816bd5c1de732d518da2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0109676https://doaj.org/toc/1932-6203White matter (WM) abnormalities have already been shown in presymptomatic (Pre-HD) and symptomatic HD subjects using Magnetic Resonance Imaging (MRI). In the present study, we examined the microstructure of the long-range large deep WM tracts by applying two different MRI approaches: Diffusion Tensor Imaging (DTI) -based tractography, and T2*weighted (iron sensitive) imaging. We collected Pre-HD subjects (n = 25), HD patients (n = 25) and healthy control subjects (n = 50). Results revealed increased axial (AD) and radial diffusivity (RD) and iron levels in Pre-HD subjects compared to controls. Fractional anisotropy decreased between the Pre-HD and HD phase and AD/RD increased and although impairment was pervasive in HD, degeneration occurred in a pattern in Pre-HD. Furthermore, iron levels dropped for HD patients. As increased iron levels are associated with remyelination, the data suggests that Pre-HD subjects attempt to repair damaged deep WM years before symptoms occur but this process fails with disease progression.Owen PhillipsFerdinando SquitieriCristina Sanchez-CastanedaFrancesca ElifaniCarlo CaltagironeUmberto SabatiniMargherita Di PaolaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e109676 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Owen Phillips Ferdinando Squitieri Cristina Sanchez-Castaneda Francesca Elifani Carlo Caltagirone Umberto Sabatini Margherita Di Paola Deep white matter in Huntington's disease.
description	White matter (WM) abnormalities have already been shown in presymptomatic (Pre-HD) and symptomatic HD subjects using Magnetic Resonance Imaging (MRI). In the present study, we examined the microstructure of the long-range large deep WM tracts by applying two different MRI approaches: Diffusion Tensor Imaging (DTI) -based tractography, and T2*weighted (iron sensitive) imaging. We collected Pre-HD subjects (n = 25), HD patients (n = 25) and healthy control subjects (n = 50). Results revealed increased axial (AD) and radial diffusivity (RD) and iron levels in Pre-HD subjects compared to controls. Fractional anisotropy decreased between the Pre-HD and HD phase and AD/RD increased and although impairment was pervasive in HD, degeneration occurred in a pattern in Pre-HD. Furthermore, iron levels dropped for HD patients. As increased iron levels are associated with remyelination, the data suggests that Pre-HD subjects attempt to repair damaged deep WM years before symptoms occur but this process fails with disease progression.
format	article
author	Owen Phillips Ferdinando Squitieri Cristina Sanchez-Castaneda Francesca Elifani Carlo Caltagirone Umberto Sabatini Margherita Di Paola
author_facet	Owen Phillips Ferdinando Squitieri Cristina Sanchez-Castaneda Francesca Elifani Carlo Caltagirone Umberto Sabatini Margherita Di Paola
author_sort	Owen Phillips
title	Deep white matter in Huntington's disease.
title_short	Deep white matter in Huntington's disease.
title_full	Deep white matter in Huntington's disease.
title_fullStr	Deep white matter in Huntington's disease.
title_full_unstemmed	Deep white matter in Huntington's disease.
title_sort	deep white matter in huntington's disease.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/9d4de6da340b4816bd5c1de732d518da
work_keys_str_mv	AT owenphillips deepwhitematterinhuntingtonsdisease AT ferdinandosquitieri deepwhitematterinhuntingtonsdisease AT cristinasanchezcastaneda deepwhitematterinhuntingtonsdisease AT francescaelifani deepwhitematterinhuntingtonsdisease AT carlocaltagirone deepwhitematterinhuntingtonsdisease AT umbertosabatini deepwhitematterinhuntingtonsdisease AT margheritadipaola deepwhitematterinhuntingtonsdisease
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Deep white matter in Huntington's disease.

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