The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

In mitosis, Aurora B switches substrate specificity in response to phosphorylation of S227 in the activation loop by a cell cycle-processed active fragment of PKCε. Here, the authors show that this switch protects from chromosome non-disjunction by delaying anaphase entry and promoting TopoIIα-depen...

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Autores principales:	Joanna R. Kelly, Silvia Martini, Nicola Brownlow, Dhira Joshi, Stefania Federico, Shirin Jamshidi, Svend Kjaer, Nicola Lockwood, Khondaker Miraz Rahman, Franca Fraternali, Peter J. Parker, Tanya N. Soliman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9d4e931c3bca49468261d029d24bfad2
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spelling	oai:doaj.org-article:9d4e931c3bca49468261d029d24bfad22021-12-02T16:50:04ZThe Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition10.1038/s41467-020-15163-62041-1723https://doaj.org/article/9d4e931c3bca49468261d029d24bfad22020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15163-6https://doaj.org/toc/2041-1723In mitosis, Aurora B switches substrate specificity in response to phosphorylation of S227 in the activation loop by a cell cycle-processed active fragment of PKCε. Here, the authors show that this switch protects from chromosome non-disjunction by delaying anaphase entry and promoting TopoIIα-dependent resolution.Joanna R. KellySilvia MartiniNicola BrownlowDhira JoshiStefania FedericoShirin JamshidiSvend KjaerNicola LockwoodKhondaker Miraz RahmanFranca FraternaliPeter J. ParkerTanya N. SolimanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joanna R. Kelly Silvia Martini Nicola Brownlow Dhira Joshi Stefania Federico Shirin Jamshidi Svend Kjaer Nicola Lockwood Khondaker Miraz Rahman Franca Fraternali Peter J. Parker Tanya N. Soliman The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition
description	In mitosis, Aurora B switches substrate specificity in response to phosphorylation of S227 in the activation loop by a cell cycle-processed active fragment of PKCε. Here, the authors show that this switch protects from chromosome non-disjunction by delaying anaphase entry and promoting TopoIIα-dependent resolution.
format	article
author	Joanna R. Kelly Silvia Martini Nicola Brownlow Dhira Joshi Stefania Federico Shirin Jamshidi Svend Kjaer Nicola Lockwood Khondaker Miraz Rahman Franca Fraternali Peter J. Parker Tanya N. Soliman
author_facet	Joanna R. Kelly Silvia Martini Nicola Brownlow Dhira Joshi Stefania Federico Shirin Jamshidi Svend Kjaer Nicola Lockwood Khondaker Miraz Rahman Franca Fraternali Peter J. Parker Tanya N. Soliman
author_sort	Joanna R. Kelly
title	The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition
title_short	The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition
title_full	The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition
title_fullStr	The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition
title_full_unstemmed	The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition
title_sort	aurora b specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9d4e931c3bca49468261d029d24bfad2
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The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

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