New targets for NAFLDKey points

Summary: Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and progressive fibrosis. Several preclinical models (dietary and genetic animal models) of NAFLD have deepened our un...

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Autores principales:	Lucia Parlati, Marion Régnier, Hervé Guillou, Catherine Postic
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	NAFLD NASH SREBP-1c ChREBP FXR LXR Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/9d4fca391fdc4664876e3b618ff56737
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spelling	oai:doaj.org-article:9d4fca391fdc4664876e3b618ff567372021-11-20T05:11:32ZNew targets for NAFLDKey points2589-555910.1016/j.jhepr.2021.100346https://doaj.org/article/9d4fca391fdc4664876e3b618ff567372021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589555921001221https://doaj.org/toc/2589-5559Summary: Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and progressive fibrosis. Several preclinical models (dietary and genetic animal models) of NAFLD have deepened our understanding of its aetiology and pathophysiology. Despite the progress made, there are currently no effective treatments for NAFLD. In this review, we will provide an update on the known molecular pathways involved in the pathophysiology of NAFLD and on ongoing studies of new therapeutic targets.Lucia ParlatiMarion RégnierHervé GuillouCatherine PosticElsevierarticleNAFLDNASHSREBP-1cChREBPFXRLXRDiseases of the digestive system. GastroenterologyRC799-869ENJHEP Reports, Vol 3, Iss 6, Pp 100346- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NAFLD NASH SREBP-1c ChREBP FXR LXR Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	NAFLD NASH SREBP-1c ChREBP FXR LXR Diseases of the digestive system. Gastroenterology RC799-869 Lucia Parlati Marion Régnier Hervé Guillou Catherine Postic New targets for NAFLDKey points
description	Summary: Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and progressive fibrosis. Several preclinical models (dietary and genetic animal models) of NAFLD have deepened our understanding of its aetiology and pathophysiology. Despite the progress made, there are currently no effective treatments for NAFLD. In this review, we will provide an update on the known molecular pathways involved in the pathophysiology of NAFLD and on ongoing studies of new therapeutic targets.
format	article
author	Lucia Parlati Marion Régnier Hervé Guillou Catherine Postic
author_facet	Lucia Parlati Marion Régnier Hervé Guillou Catherine Postic
author_sort	Lucia Parlati
title	New targets for NAFLDKey points
title_short	New targets for NAFLDKey points
title_full	New targets for NAFLDKey points
title_fullStr	New targets for NAFLDKey points
title_full_unstemmed	New targets for NAFLDKey points
title_sort	new targets for nafldkey points
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9d4fca391fdc4664876e3b618ff56737
work_keys_str_mv	AT luciaparlati newtargetsfornafldkeypoints AT marionregnier newtargetsfornafldkeypoints AT herveguillou newtargetsfornafldkeypoints AT catherinepostic newtargetsfornafldkeypoints
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New targets for NAFLDKey points

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