The cortical signature of amyotrophic lateral sclerosis.

The aim of this study was to explore the pattern of regional cortical thickness in patients with non-familial amyotrophic lateral sclerosis (ALS) and to investigate whether cortical thinning is associated with disease progression rate. Cortical thickness analysis was performed in 44 ALS patients and...

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Autores principales:	Federica Agosta, Paola Valsasina, Nilo Riva, Massimiliano Copetti, Maria Josè Messina, Alessandro Prelle, Giancarlo Comi, Massimo Filippi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9d5a3011c4c04596a0f56f028bf2d7c4
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spelling	oai:doaj.org-article:9d5a3011c4c04596a0f56f028bf2d7c42021-11-18T07:09:31ZThe cortical signature of amyotrophic lateral sclerosis.1932-620310.1371/journal.pone.0042816https://doaj.org/article/9d5a3011c4c04596a0f56f028bf2d7c42012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22880116/?tool=EBIhttps://doaj.org/toc/1932-6203The aim of this study was to explore the pattern of regional cortical thickness in patients with non-familial amyotrophic lateral sclerosis (ALS) and to investigate whether cortical thinning is associated with disease progression rate. Cortical thickness analysis was performed in 44 ALS patients and 26 healthy controls. Group differences in cortical thickness and the age-by-group effects were assessed using vertex-by-vertex and multivariate linear models. The discriminatory ability of MRI variables in distinguishing patients from controls was estimated using the Concordance Statistics (C-statistic) within logistic regression analyses. Correlations between cortical thickness measures and disease progression rate were tested using the Pearson coefficient. Relative to controls, ALS patients showed a bilateral cortical thinning of the primary motor, prefrontal and ventral frontal cortices, cingulate gyrus, insula, superior and inferior temporal and parietal regions, and medial and lateral occipital areas. There was a significant age-by-group effect in the sensorimotor cortices bilaterally, suggesting a stronger association between age and cortical thinning in ALS patients compared to controls. The mean cortical thickness of the sensorimotor cortices distinguished patients with ALS from controls (C-statistic ≥ 0.74). Cortical thinning of the left sensorimotor cortices was related to a faster clinical progression (r = -0.33, p = 0.03). Cortical thickness measurements allowed the detection and quantification of motor and extramotor involvement in patients with ALS. Cortical thinning of the precentral gyrus might offer a marker of upper motor neuron involvement and disease progression.Federica AgostaPaola ValsasinaNilo RivaMassimiliano CopettiMaria Josè MessinaAlessandro PrelleGiancarlo ComiMassimo FilippiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e42816 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Federica Agosta Paola Valsasina Nilo Riva Massimiliano Copetti Maria Josè Messina Alessandro Prelle Giancarlo Comi Massimo Filippi The cortical signature of amyotrophic lateral sclerosis.
description	The aim of this study was to explore the pattern of regional cortical thickness in patients with non-familial amyotrophic lateral sclerosis (ALS) and to investigate whether cortical thinning is associated with disease progression rate. Cortical thickness analysis was performed in 44 ALS patients and 26 healthy controls. Group differences in cortical thickness and the age-by-group effects were assessed using vertex-by-vertex and multivariate linear models. The discriminatory ability of MRI variables in distinguishing patients from controls was estimated using the Concordance Statistics (C-statistic) within logistic regression analyses. Correlations between cortical thickness measures and disease progression rate were tested using the Pearson coefficient. Relative to controls, ALS patients showed a bilateral cortical thinning of the primary motor, prefrontal and ventral frontal cortices, cingulate gyrus, insula, superior and inferior temporal and parietal regions, and medial and lateral occipital areas. There was a significant age-by-group effect in the sensorimotor cortices bilaterally, suggesting a stronger association between age and cortical thinning in ALS patients compared to controls. The mean cortical thickness of the sensorimotor cortices distinguished patients with ALS from controls (C-statistic ≥ 0.74). Cortical thinning of the left sensorimotor cortices was related to a faster clinical progression (r = -0.33, p = 0.03). Cortical thickness measurements allowed the detection and quantification of motor and extramotor involvement in patients with ALS. Cortical thinning of the precentral gyrus might offer a marker of upper motor neuron involvement and disease progression.
format	article
author	Federica Agosta Paola Valsasina Nilo Riva Massimiliano Copetti Maria Josè Messina Alessandro Prelle Giancarlo Comi Massimo Filippi
author_facet	Federica Agosta Paola Valsasina Nilo Riva Massimiliano Copetti Maria Josè Messina Alessandro Prelle Giancarlo Comi Massimo Filippi
author_sort	Federica Agosta
title	The cortical signature of amyotrophic lateral sclerosis.
title_short	The cortical signature of amyotrophic lateral sclerosis.
title_full	The cortical signature of amyotrophic lateral sclerosis.
title_fullStr	The cortical signature of amyotrophic lateral sclerosis.
title_full_unstemmed	The cortical signature of amyotrophic lateral sclerosis.
title_sort	cortical signature of amyotrophic lateral sclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/9d5a3011c4c04596a0f56f028bf2d7c4
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The cortical signature of amyotrophic lateral sclerosis.

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