Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint

Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint

Cells delay completion of cytokinesis when chromatin is trapped at the intercellular bridge. Here, Petsalaki and Zachos report that Cdc-like kinases (Clks) 1, 2 and 4 localize to the midbody and phosphorylate the mitotic kinase Aurora B, imposing the abscission checkpoint to prevent premature abscis...

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Autores principales: Eleni Petsalaki, George Zachos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/9d5b3d185ff04c38b310750b2fa41682
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spelling oai:doaj.org-article:9d5b3d185ff04c38b310750b2fa416822021-12-02T14:39:31ZClks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint10.1038/ncomms114512041-1723https://doaj.org/article/9d5b3d185ff04c38b310750b2fa416822016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11451https://doaj.org/toc/2041-1723Cells delay completion of cytokinesis when chromatin is trapped at the intercellular bridge. Here, Petsalaki and Zachos report that Cdc-like kinases (Clks) 1, 2 and 4 localize to the midbody and phosphorylate the mitotic kinase Aurora B, imposing the abscission checkpoint to prevent premature abscission and chromatin breakage.Eleni PetsalakiGeorge ZachosNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Eleni Petsalaki
George Zachos
Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint
description Cells delay completion of cytokinesis when chromatin is trapped at the intercellular bridge. Here, Petsalaki and Zachos report that Cdc-like kinases (Clks) 1, 2 and 4 localize to the midbody and phosphorylate the mitotic kinase Aurora B, imposing the abscission checkpoint to prevent premature abscission and chromatin breakage.
format article
author Eleni Petsalaki
George Zachos
author_facet Eleni Petsalaki
George Zachos
author_sort Eleni Petsalaki
title Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint
title_short Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint
title_full Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint
title_fullStr Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint
title_full_unstemmed Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint
title_sort clks 1, 2 and 4 prevent chromatin breakage by regulating the aurora b-dependent abscission checkpoint
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/9d5b3d185ff04c38b310750b2fa41682
work_keys_str_mv AT elenipetsalaki clks12and4preventchromatinbreakagebyregulatingtheaurorabdependentabscissioncheckpoint
AT georgezachos clks12and4preventchromatinbreakagebyregulatingtheaurorabdependentabscissioncheckpoint
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