Association between overall diet quality and postmenopausal breast cancer risk in five Finnish cohort studies

Abstract There is limited evidence for any dietary factor, except alcohol, in breast cancer (BC) risk. Therefore, studies on a whole diet, using diet quality indices, can broaden our insight. We examined associations of the Nordic Diet (mNDI), Mediterranean diet (mMEDI) and Alternative Healthy Eatin...

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Autores principales:	Satu Männistö, Kennet Harald, Tommi Härkänen, Mirkka Maukonen, Johan G. Eriksson, Sanna Heikkinen, Pekka Jousilahti, Niina E. Kaartinen, Noora Kanerva, Paul Knekt, Seppo Koskinen, Maarit A. Laaksonen, Nea Malila, Harri Rissanen, Janne Pitkäniemi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9d5b44616b4f48d59d6710a480848968
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spelling	oai:doaj.org-article:9d5b44616b4f48d59d6710a4808489682021-12-02T15:10:46ZAssociation between overall diet quality and postmenopausal breast cancer risk in five Finnish cohort studies10.1038/s41598-021-95773-22045-2322https://doaj.org/article/9d5b44616b4f48d59d6710a4808489682021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95773-2https://doaj.org/toc/2045-2322Abstract There is limited evidence for any dietary factor, except alcohol, in breast cancer (BC) risk. Therefore, studies on a whole diet, using diet quality indices, can broaden our insight. We examined associations of the Nordic Diet (mNDI), Mediterranean diet (mMEDI) and Alternative Healthy Eating Index (mAHEI) with postmenopausal BC risk. Five Finnish cohorts were combined including 6374 postmenopausal women with dietary information. In all, 8–9 dietary components were aggregated in each index, higher total score indicating higher adherence to a healthy diet. Cox proportional hazards regression was used to estimate the combined hazard ratio (HR) and 95% confidence interval (CI) for BC risk. During an average 10-year follow-up period, 274 incident postmenopausal BC cases were diagnosed. In multivariable models, the HR for highest vs. lowest quintile of index was 0.67 (95 %CI 0.48–1.01) for mNDI, 0.88 (0.59–1.30) for mMEDI and 0.89 (0.60–1.32) for mAHEI. In this combined dataset, a borderline preventive finding of high adherence to mNDI on postmenopausal BC risk was found. Of the indices, mNDI was more based on the local food culture than the others. Although a healthy diet has beneficially been related to several chronic diseases, the link with the etiology of postmenopausal BC does not seem to be that obvious.Satu MännistöKennet HaraldTommi HärkänenMirkka MaukonenJohan G. ErikssonSanna HeikkinenPekka JousilahtiNiina E. KaartinenNoora KanervaPaul KnektSeppo KoskinenMaarit A. LaaksonenNea MalilaHarri RissanenJanne PitkäniemiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Satu Männistö Kennet Harald Tommi Härkänen Mirkka Maukonen Johan G. Eriksson Sanna Heikkinen Pekka Jousilahti Niina E. Kaartinen Noora Kanerva Paul Knekt Seppo Koskinen Maarit A. Laaksonen Nea Malila Harri Rissanen Janne Pitkäniemi Association between overall diet quality and postmenopausal breast cancer risk in five Finnish cohort studies
description	Abstract There is limited evidence for any dietary factor, except alcohol, in breast cancer (BC) risk. Therefore, studies on a whole diet, using diet quality indices, can broaden our insight. We examined associations of the Nordic Diet (mNDI), Mediterranean diet (mMEDI) and Alternative Healthy Eating Index (mAHEI) with postmenopausal BC risk. Five Finnish cohorts were combined including 6374 postmenopausal women with dietary information. In all, 8–9 dietary components were aggregated in each index, higher total score indicating higher adherence to a healthy diet. Cox proportional hazards regression was used to estimate the combined hazard ratio (HR) and 95% confidence interval (CI) for BC risk. During an average 10-year follow-up period, 274 incident postmenopausal BC cases were diagnosed. In multivariable models, the HR for highest vs. lowest quintile of index was 0.67 (95 %CI 0.48–1.01) for mNDI, 0.88 (0.59–1.30) for mMEDI and 0.89 (0.60–1.32) for mAHEI. In this combined dataset, a borderline preventive finding of high adherence to mNDI on postmenopausal BC risk was found. Of the indices, mNDI was more based on the local food culture than the others. Although a healthy diet has beneficially been related to several chronic diseases, the link with the etiology of postmenopausal BC does not seem to be that obvious.
format	article
author	Satu Männistö Kennet Harald Tommi Härkänen Mirkka Maukonen Johan G. Eriksson Sanna Heikkinen Pekka Jousilahti Niina E. Kaartinen Noora Kanerva Paul Knekt Seppo Koskinen Maarit A. Laaksonen Nea Malila Harri Rissanen Janne Pitkäniemi
author_facet	Satu Männistö Kennet Harald Tommi Härkänen Mirkka Maukonen Johan G. Eriksson Sanna Heikkinen Pekka Jousilahti Niina E. Kaartinen Noora Kanerva Paul Knekt Seppo Koskinen Maarit A. Laaksonen Nea Malila Harri Rissanen Janne Pitkäniemi
author_sort	Satu Männistö
title	Association between overall diet quality and postmenopausal breast cancer risk in five Finnish cohort studies
title_short	Association between overall diet quality and postmenopausal breast cancer risk in five Finnish cohort studies
title_full	Association between overall diet quality and postmenopausal breast cancer risk in five Finnish cohort studies
title_fullStr	Association between overall diet quality and postmenopausal breast cancer risk in five Finnish cohort studies
title_full_unstemmed	Association between overall diet quality and postmenopausal breast cancer risk in five Finnish cohort studies
title_sort	association between overall diet quality and postmenopausal breast cancer risk in five finnish cohort studies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9d5b44616b4f48d59d6710a480848968
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Association between overall diet quality and postmenopausal breast cancer risk in five Finnish cohort studies

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