Beneficial effects of Japanese sake yeast supplement on biochemical, antioxidant, and anti-inflammatory factors in streptozotocin-induced diabetic rats

Marzieh Davoodi,1 Faezeh Nemati Karimooy,2 Thomas Budde,3 Sylvia Ortega-Martinez,4 Nasroallah Moradi-Kor51Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran; 2Department of Neuroscience, Medical School, Mashhad University of Medical Sciences, Mashhad, Ir...

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Autores principales:	Davoodi M, Karimooy FN, Budde T, Ortega-Martinez S, Moradi-Kor N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Sake yeast Diabetes Glucose Insulin Inflammatory factors Lipid Profile Antioxidants Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/9d5be884d669455ba9cf81e7a900dc53
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spelling	oai:doaj.org-article:9d5be884d669455ba9cf81e7a900dc532021-12-02T03:21:51ZBeneficial effects of Japanese sake yeast supplement on biochemical, antioxidant, and anti-inflammatory factors in streptozotocin-induced diabetic rats1178-7007https://doaj.org/article/9d5be884d669455ba9cf81e7a900dc532019-09-01T00:00:00Zhttps://www.dovepress.com/beneficial-effects-of-japanese-sake-yeast-supplement-on-biochemical-an-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Marzieh Davoodi,1 Faezeh Nemati Karimooy,2 Thomas Budde,3 Sylvia Ortega-Martinez,4 Nasroallah Moradi-Kor51Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran; 2Department of Neuroscience, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran; 3Institute of Physiology I, Westfälische Wilhelms-University, Münster, Germany; 4Department of Neurobiology, The University of Chicago, Chicago, IL, USA; 5Research Center of Physiology, Semnan University of Medical Sciences, Semnan, IranCorrespondence: Nasroallah Moradi-KorResearch Center of Physiology, Semnan University of Medical Sciences, Damghan Road, PO Box 35195-163, Semnan, IranTel +98 233 365 4207Email moradikor@semums.ac.irBackground: Using chemical agents in the treatment of diabetes mellitus type 2 may have some limitations due to frequent side effects. Some novel and natural agents may be promising alternatives in this case. This study was designed to evaluate the effects of oral Japanese sake yeast supplement, as a novel agent, on biochemical antioxidant and anti-inflammatory parameters in experimentally induced diabetic rats.Materials and methods: After inducing diabetes (55 mg/kg intraperitoneal injection of streptozotocin), 120 male adult Wistar rats were randomly divided into 5 groups and each group received 0 (control), 15, 30, or 45 mg/kg of sake yeast or was considered a nondiabetic control. Then, the serum levels of tumor necrosis factor-α, IL-6, C-reactive protein, malondialdehyde, glutathione, total antioxidant status, glucose, cholesterol, triglycerides, and insulin were evaluated and compared to baseline measures.Results: The results showed that oral administration of sake yeast at different concentrations reduced levels of malondialdehyde, glucose, cholesterol, and triglycerides and increased levels of insulin, glutathione, and total antioxidants (P<0.05). The best responses were observed in the nondiabetic control group.Conclusion: Sake yeast supplement may be useful as a novel agent in the treatment of diabetes.Keywords: sake yeast, diabetes, glucose, insulin, inflammatory factors, lipid profile, antioxidantsDavoodi MKarimooy FNBudde TOrtega-Martinez SMoradi-Kor NDove Medical PressarticleSake yeastDiabetesGlucoseInsulinInflammatory factorsLipid ProfileAntioxidantsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 1667-1673 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sake yeast Diabetes Glucose Insulin Inflammatory factors Lipid Profile Antioxidants Specialties of internal medicine RC581-951
spellingShingle	Sake yeast Diabetes Glucose Insulin Inflammatory factors Lipid Profile Antioxidants Specialties of internal medicine RC581-951 Davoodi M Karimooy FN Budde T Ortega-Martinez S Moradi-Kor N Beneficial effects of Japanese sake yeast supplement on biochemical, antioxidant, and anti-inflammatory factors in streptozotocin-induced diabetic rats
description	Marzieh Davoodi,1 Faezeh Nemati Karimooy,2 Thomas Budde,3 Sylvia Ortega-Martinez,4 Nasroallah Moradi-Kor51Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran; 2Department of Neuroscience, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran; 3Institute of Physiology I, Westfälische Wilhelms-University, Münster, Germany; 4Department of Neurobiology, The University of Chicago, Chicago, IL, USA; 5Research Center of Physiology, Semnan University of Medical Sciences, Semnan, IranCorrespondence: Nasroallah Moradi-KorResearch Center of Physiology, Semnan University of Medical Sciences, Damghan Road, PO Box 35195-163, Semnan, IranTel +98 233 365 4207Email moradikor@semums.ac.irBackground: Using chemical agents in the treatment of diabetes mellitus type 2 may have some limitations due to frequent side effects. Some novel and natural agents may be promising alternatives in this case. This study was designed to evaluate the effects of oral Japanese sake yeast supplement, as a novel agent, on biochemical antioxidant and anti-inflammatory parameters in experimentally induced diabetic rats.Materials and methods: After inducing diabetes (55 mg/kg intraperitoneal injection of streptozotocin), 120 male adult Wistar rats were randomly divided into 5 groups and each group received 0 (control), 15, 30, or 45 mg/kg of sake yeast or was considered a nondiabetic control. Then, the serum levels of tumor necrosis factor-α, IL-6, C-reactive protein, malondialdehyde, glutathione, total antioxidant status, glucose, cholesterol, triglycerides, and insulin were evaluated and compared to baseline measures.Results: The results showed that oral administration of sake yeast at different concentrations reduced levels of malondialdehyde, glucose, cholesterol, and triglycerides and increased levels of insulin, glutathione, and total antioxidants (P<0.05). The best responses were observed in the nondiabetic control group.Conclusion: Sake yeast supplement may be useful as a novel agent in the treatment of diabetes.Keywords: sake yeast, diabetes, glucose, insulin, inflammatory factors, lipid profile, antioxidants
format	article
author	Davoodi M Karimooy FN Budde T Ortega-Martinez S Moradi-Kor N
author_facet	Davoodi M Karimooy FN Budde T Ortega-Martinez S Moradi-Kor N
author_sort	Davoodi M
title	Beneficial effects of Japanese sake yeast supplement on biochemical, antioxidant, and anti-inflammatory factors in streptozotocin-induced diabetic rats
title_short	Beneficial effects of Japanese sake yeast supplement on biochemical, antioxidant, and anti-inflammatory factors in streptozotocin-induced diabetic rats
title_full	Beneficial effects of Japanese sake yeast supplement on biochemical, antioxidant, and anti-inflammatory factors in streptozotocin-induced diabetic rats
title_fullStr	Beneficial effects of Japanese sake yeast supplement on biochemical, antioxidant, and anti-inflammatory factors in streptozotocin-induced diabetic rats
title_full_unstemmed	Beneficial effects of Japanese sake yeast supplement on biochemical, antioxidant, and anti-inflammatory factors in streptozotocin-induced diabetic rats
title_sort	beneficial effects of japanese sake yeast supplement on biochemical, antioxidant, and anti-inflammatory factors in streptozotocin-induced diabetic rats
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/9d5be884d669455ba9cf81e7a900dc53
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Beneficial effects of Japanese sake yeast supplement on biochemical, antioxidant, and anti-inflammatory factors in streptozotocin-induced diabetic rats

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