Programmed Cell Death: Complex Regulatory Networks in Cardiovascular Disease

Abnormalities in programmed cell death (PCD) signaling cascades can be observed in the development and progression of various cardiovascular diseases, such as apoptosis, necrosis, pyroptosis, ferroptosis, and cell death associated with autophagy. Aberrant activation of PCD pathways is a common featu...

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Autores principales:	Liuhua Zhou, Jiateng Sun, Lingfeng Gu, Sibo Wang, Tongtong Yang, Tianwen Wei, Tiankai Shan, Hao Wang, Liansheng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cardiovascular diseases programmed cell death apoptosis necrosis autophagy pyroptosis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9d5dc3f3708e484b9bbd1fb126889afb
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spelling	oai:doaj.org-article:9d5dc3f3708e484b9bbd1fb126889afb2021-12-01T05:41:18ZProgrammed Cell Death: Complex Regulatory Networks in Cardiovascular Disease2296-634X10.3389/fcell.2021.794879https://doaj.org/article/9d5dc3f3708e484b9bbd1fb126889afb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.794879/fullhttps://doaj.org/toc/2296-634XAbnormalities in programmed cell death (PCD) signaling cascades can be observed in the development and progression of various cardiovascular diseases, such as apoptosis, necrosis, pyroptosis, ferroptosis, and cell death associated with autophagy. Aberrant activation of PCD pathways is a common feature leading to excessive cardiac remodeling and heart failure, involved in the pathogenesis of various cardiovascular diseases. Conversely, timely activation of PCD remodels cardiac structure and function after injury in a spatially or temporally restricted manner and corrects cardiac development similarly. As many cardiovascular diseases exhibit abnormalities in PCD pathways, drugs that can inhibit or modulate PCD may be critical in future therapeutic strategies. In this review, we briefly describe the process of various types of PCD and their roles in the occurrence and development of cardiovascular diseases. We also discuss the interplay between different cell death signaling cascades and summarize pharmaceutical agents targeting key players in cell death signaling pathways that have progressed to clinical trials. Ultimately a better understanding of PCD involved in cardiovascular diseases may lead to new avenues for therapy.Liuhua ZhouJiateng SunLingfeng GuSibo WangTongtong YangTianwen WeiTiankai ShanHao WangLiansheng WangFrontiers Media S.A.articlecardiovascular diseasesprogrammed cell deathapoptosisnecrosisautophagypyroptosisBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular diseases programmed cell death apoptosis necrosis autophagy pyroptosis Biology (General) QH301-705.5
spellingShingle	cardiovascular diseases programmed cell death apoptosis necrosis autophagy pyroptosis Biology (General) QH301-705.5 Liuhua Zhou Jiateng Sun Lingfeng Gu Sibo Wang Tongtong Yang Tianwen Wei Tiankai Shan Hao Wang Liansheng Wang Programmed Cell Death: Complex Regulatory Networks in Cardiovascular Disease
description	Abnormalities in programmed cell death (PCD) signaling cascades can be observed in the development and progression of various cardiovascular diseases, such as apoptosis, necrosis, pyroptosis, ferroptosis, and cell death associated with autophagy. Aberrant activation of PCD pathways is a common feature leading to excessive cardiac remodeling and heart failure, involved in the pathogenesis of various cardiovascular diseases. Conversely, timely activation of PCD remodels cardiac structure and function after injury in a spatially or temporally restricted manner and corrects cardiac development similarly. As many cardiovascular diseases exhibit abnormalities in PCD pathways, drugs that can inhibit or modulate PCD may be critical in future therapeutic strategies. In this review, we briefly describe the process of various types of PCD and their roles in the occurrence and development of cardiovascular diseases. We also discuss the interplay between different cell death signaling cascades and summarize pharmaceutical agents targeting key players in cell death signaling pathways that have progressed to clinical trials. Ultimately a better understanding of PCD involved in cardiovascular diseases may lead to new avenues for therapy.
format	article
author	Liuhua Zhou Jiateng Sun Lingfeng Gu Sibo Wang Tongtong Yang Tianwen Wei Tiankai Shan Hao Wang Liansheng Wang
author_facet	Liuhua Zhou Jiateng Sun Lingfeng Gu Sibo Wang Tongtong Yang Tianwen Wei Tiankai Shan Hao Wang Liansheng Wang
author_sort	Liuhua Zhou
title	Programmed Cell Death: Complex Regulatory Networks in Cardiovascular Disease
title_short	Programmed Cell Death: Complex Regulatory Networks in Cardiovascular Disease
title_full	Programmed Cell Death: Complex Regulatory Networks in Cardiovascular Disease
title_fullStr	Programmed Cell Death: Complex Regulatory Networks in Cardiovascular Disease
title_full_unstemmed	Programmed Cell Death: Complex Regulatory Networks in Cardiovascular Disease
title_sort	programmed cell death: complex regulatory networks in cardiovascular disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9d5dc3f3708e484b9bbd1fb126889afb
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Programmed Cell Death: Complex Regulatory Networks in Cardiovascular Disease

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