Effects of short-term nutritional interventions on right ventricular function in healthy men.

<h4>Background</h4>A physiological model of increased plasma nonesterified fatty acid (NEFA) levels result in myocardial triglyceride (TG) accumulation, which is related to cardiac dysfunction. A pathophysiological model of increased plasma NEFA levels result in hepatic steatosis, which...

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Autores principales:	Ralph L Widya, Sebastiaan Hammer, Mariëtte R Boon, Rutger W van der Meer, Johannes W A Smit, Albert de Roos, Patrick C N Rensen, Hildo J Lamb
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9d5e8accfdb34d61827d192e1a917984
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spelling	oai:doaj.org-article:9d5e8accfdb34d61827d192e1a9179842021-11-18T08:54:14ZEffects of short-term nutritional interventions on right ventricular function in healthy men.1932-620310.1371/journal.pone.0076406https://doaj.org/article/9d5e8accfdb34d61827d192e1a9179842013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086738/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A physiological model of increased plasma nonesterified fatty acid (NEFA) levels result in myocardial triglyceride (TG) accumulation, which is related to cardiac dysfunction. A pathophysiological model of increased plasma NEFA levels result in hepatic steatosis, which has been linked to abnormal myocardial energy metabolism. Hepatic steatosis is accompanied by hepatic inflammation, reflected by plasma cholesteryl ester transfer protein (CETP) levels. The current study aimed to investigate effects of these models via different nutritional interventions on right ventricular (RV) function.<h4>Methods</h4>Fifteen men (age 25.0±6.6 years) were included and underwent magnetic resonance imaging and spectroscopy in this prospective crossover intervention study. RV function, myocardial and hepatic TG content, and CETP levels were assessed on three occasions: after normal diet, very low-calorie diet (VLCD, physiological model) and high-fat high-energy (HFHE, pathophysiological model) diet (all 3-days diets, randomly ordered, washout phase at least 14 days).<h4>Results</h4>VLCD induced a decrease in mean E deceleration by 27%. Myocardial TG content increased by 55%, whereas hepatic TG content decreased by 32%. Plasma CETP levels decreased by 14% (all P<0.05). HFHE diet induced a decrease in E/A by 19% (P<0.05). Myocardial TG content did not change, whereas hepatic TG content increased by 112% (P<0.01). Plasma CETP levels increased by 14% (P<0.05).<h4>Conclusions</h4>These findings show that RV diastolic function is impaired after short-term VLCD and HFHE diet in healthy men, respectively a physiological and a pathophysiological model of increased plasma NEFA levels. After short-term VLCD, myocardial lipotoxicity may be of importance in decreased RV diastolic function. RV diastolic dysfunction is accompanied by increased hepatic TG content and plasma CETP levels after short-term HFHE diet, suggesting that systemic inflammation reflecting local macrophage infiltration in the heart may be involved in RV dysfunction.Ralph L WidyaSebastiaan HammerMariëtte R BoonRutger W van der MeerJohannes W A SmitAlbert de RoosPatrick C N RensenHildo J LambPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e76406 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ralph L Widya Sebastiaan Hammer Mariëtte R Boon Rutger W van der Meer Johannes W A Smit Albert de Roos Patrick C N Rensen Hildo J Lamb Effects of short-term nutritional interventions on right ventricular function in healthy men.
description	<h4>Background</h4>A physiological model of increased plasma nonesterified fatty acid (NEFA) levels result in myocardial triglyceride (TG) accumulation, which is related to cardiac dysfunction. A pathophysiological model of increased plasma NEFA levels result in hepatic steatosis, which has been linked to abnormal myocardial energy metabolism. Hepatic steatosis is accompanied by hepatic inflammation, reflected by plasma cholesteryl ester transfer protein (CETP) levels. The current study aimed to investigate effects of these models via different nutritional interventions on right ventricular (RV) function.<h4>Methods</h4>Fifteen men (age 25.0±6.6 years) were included and underwent magnetic resonance imaging and spectroscopy in this prospective crossover intervention study. RV function, myocardial and hepatic TG content, and CETP levels were assessed on three occasions: after normal diet, very low-calorie diet (VLCD, physiological model) and high-fat high-energy (HFHE, pathophysiological model) diet (all 3-days diets, randomly ordered, washout phase at least 14 days).<h4>Results</h4>VLCD induced a decrease in mean E deceleration by 27%. Myocardial TG content increased by 55%, whereas hepatic TG content decreased by 32%. Plasma CETP levels decreased by 14% (all P<0.05). HFHE diet induced a decrease in E/A by 19% (P<0.05). Myocardial TG content did not change, whereas hepatic TG content increased by 112% (P<0.01). Plasma CETP levels increased by 14% (P<0.05).<h4>Conclusions</h4>These findings show that RV diastolic function is impaired after short-term VLCD and HFHE diet in healthy men, respectively a physiological and a pathophysiological model of increased plasma NEFA levels. After short-term VLCD, myocardial lipotoxicity may be of importance in decreased RV diastolic function. RV diastolic dysfunction is accompanied by increased hepatic TG content and plasma CETP levels after short-term HFHE diet, suggesting that systemic inflammation reflecting local macrophage infiltration in the heart may be involved in RV dysfunction.
format	article
author	Ralph L Widya Sebastiaan Hammer Mariëtte R Boon Rutger W van der Meer Johannes W A Smit Albert de Roos Patrick C N Rensen Hildo J Lamb
author_facet	Ralph L Widya Sebastiaan Hammer Mariëtte R Boon Rutger W van der Meer Johannes W A Smit Albert de Roos Patrick C N Rensen Hildo J Lamb
author_sort	Ralph L Widya
title	Effects of short-term nutritional interventions on right ventricular function in healthy men.
title_short	Effects of short-term nutritional interventions on right ventricular function in healthy men.
title_full	Effects of short-term nutritional interventions on right ventricular function in healthy men.
title_fullStr	Effects of short-term nutritional interventions on right ventricular function in healthy men.
title_full_unstemmed	Effects of short-term nutritional interventions on right ventricular function in healthy men.
title_sort	effects of short-term nutritional interventions on right ventricular function in healthy men.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/9d5e8accfdb34d61827d192e1a917984
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Effects of short-term nutritional interventions on right ventricular function in healthy men.

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