TCR signal strength controls thymic differentiation of iNKT cell subsets

Invariant natural killer T (iNKT) cells can be subsetted by their cytokine profiles, but how they develop in the thymus is unclear. Here the authors show, by analysing mice carrying mutant Zap70 genes, that T cell receptor signaling strength induces epigenetic changes of genes to modulate iNKT linea...

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Autores principales:	Kathryn D. Tuttle, S. Harsha Krovi, Jingjing Zhang, Romain Bedel, Laura Harmacek, Lisa K. Peterson, Leonard L. Dragone, Adam Lefferts, Catherine Halluszczak, Kent Riemondy, Jay R. Hesselberth, Anjana Rao, Brian P. O’Connor, Philippa Marrack, James Scott-Browne, Laurent Gapin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9d629b4edd534fecb283ec7b354fbbc7
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spelling	oai:doaj.org-article:9d629b4edd534fecb283ec7b354fbbc72021-12-02T16:57:00ZTCR signal strength controls thymic differentiation of iNKT cell subsets10.1038/s41467-018-05026-62041-1723https://doaj.org/article/9d629b4edd534fecb283ec7b354fbbc72018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05026-6https://doaj.org/toc/2041-1723Invariant natural killer T (iNKT) cells can be subsetted by their cytokine profiles, but how they develop in the thymus is unclear. Here the authors show, by analysing mice carrying mutant Zap70 genes, that T cell receptor signaling strength induces epigenetic changes of genes to modulate iNKT lineages.Kathryn D. TuttleS. Harsha KroviJingjing ZhangRomain BedelLaura HarmacekLisa K. PetersonLeonard L. DragoneAdam LeffertsCatherine HalluszczakKent RiemondyJay R. HesselberthAnjana RaoBrian P. O’ConnorPhilippa MarrackJames Scott-BrowneLaurent GapinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kathryn D. Tuttle S. Harsha Krovi Jingjing Zhang Romain Bedel Laura Harmacek Lisa K. Peterson Leonard L. Dragone Adam Lefferts Catherine Halluszczak Kent Riemondy Jay R. Hesselberth Anjana Rao Brian P. O’Connor Philippa Marrack James Scott-Browne Laurent Gapin TCR signal strength controls thymic differentiation of iNKT cell subsets
description	Invariant natural killer T (iNKT) cells can be subsetted by their cytokine profiles, but how they develop in the thymus is unclear. Here the authors show, by analysing mice carrying mutant Zap70 genes, that T cell receptor signaling strength induces epigenetic changes of genes to modulate iNKT lineages.
format	article
author	Kathryn D. Tuttle S. Harsha Krovi Jingjing Zhang Romain Bedel Laura Harmacek Lisa K. Peterson Leonard L. Dragone Adam Lefferts Catherine Halluszczak Kent Riemondy Jay R. Hesselberth Anjana Rao Brian P. O’Connor Philippa Marrack James Scott-Browne Laurent Gapin
author_facet	Kathryn D. Tuttle S. Harsha Krovi Jingjing Zhang Romain Bedel Laura Harmacek Lisa K. Peterson Leonard L. Dragone Adam Lefferts Catherine Halluszczak Kent Riemondy Jay R. Hesselberth Anjana Rao Brian P. O’Connor Philippa Marrack James Scott-Browne Laurent Gapin
author_sort	Kathryn D. Tuttle
title	TCR signal strength controls thymic differentiation of iNKT cell subsets
title_short	TCR signal strength controls thymic differentiation of iNKT cell subsets
title_full	TCR signal strength controls thymic differentiation of iNKT cell subsets
title_fullStr	TCR signal strength controls thymic differentiation of iNKT cell subsets
title_full_unstemmed	TCR signal strength controls thymic differentiation of iNKT cell subsets
title_sort	tcr signal strength controls thymic differentiation of inkt cell subsets
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9d629b4edd534fecb283ec7b354fbbc7
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TCR signal strength controls thymic differentiation of iNKT cell subsets

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