Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting
Proteomics can aid in the identification of molecular subtypes in cancers. Here, the authors perform proteomic profiling of 124 paired oesophageal cancer and adjacent non-tumour tissues and identify two subtypes that are associated with patient survival for therapeutic targeting.
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Nature Portfolio
2021
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oai:doaj.org-article:9d695a233ef54642ace9e04ed24b58832021-12-02T17:08:39ZLarge-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting10.1038/s41467-021-25202-52041-1723https://doaj.org/article/9d695a233ef54642ace9e04ed24b58832021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25202-5https://doaj.org/toc/2041-1723Proteomics can aid in the identification of molecular subtypes in cancers. Here, the authors perform proteomic profiling of 124 paired oesophageal cancer and adjacent non-tumour tissues and identify two subtypes that are associated with patient survival for therapeutic targeting.Wei LiuLei XieYao-Hui HeZhi-Yong WuLu-Xin LiuXue-Feng BaiDan-Xia DengXiu-E XuLian-Di LiaoWan LinJing-Hua HengXin XuLiu PengQing-Feng HuangCheng-Yu LiZhi-Da ZhangWei WangGuo-Rui ZhangXiang GaoShao-Hong WangChun-Quan LiLi-Yan XuWen LiuEn-Min LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Wei Liu Lei Xie Yao-Hui He Zhi-Yong Wu Lu-Xin Liu Xue-Feng Bai Dan-Xia Deng Xiu-E Xu Lian-Di Liao Wan Lin Jing-Hua Heng Xin Xu Liu Peng Qing-Feng Huang Cheng-Yu Li Zhi-Da Zhang Wei Wang Guo-Rui Zhang Xiang Gao Shao-Hong Wang Chun-Quan Li Li-Yan Xu Wen Liu En-Min Li Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting |
| description |
Proteomics can aid in the identification of molecular subtypes in cancers. Here, the authors perform proteomic profiling of 124 paired oesophageal cancer and adjacent non-tumour tissues and identify two subtypes that are associated with patient survival for therapeutic targeting. |
| format |
article |
| author |
Wei Liu Lei Xie Yao-Hui He Zhi-Yong Wu Lu-Xin Liu Xue-Feng Bai Dan-Xia Deng Xiu-E Xu Lian-Di Liao Wan Lin Jing-Hua Heng Xin Xu Liu Peng Qing-Feng Huang Cheng-Yu Li Zhi-Da Zhang Wei Wang Guo-Rui Zhang Xiang Gao Shao-Hong Wang Chun-Quan Li Li-Yan Xu Wen Liu En-Min Li |
| author_facet |
Wei Liu Lei Xie Yao-Hui He Zhi-Yong Wu Lu-Xin Liu Xue-Feng Bai Dan-Xia Deng Xiu-E Xu Lian-Di Liao Wan Lin Jing-Hua Heng Xin Xu Liu Peng Qing-Feng Huang Cheng-Yu Li Zhi-Da Zhang Wei Wang Guo-Rui Zhang Xiang Gao Shao-Hong Wang Chun-Quan Li Li-Yan Xu Wen Liu En-Min Li |
| author_sort |
Wei Liu |
| title |
Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting |
| title_short |
Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting |
| title_full |
Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting |
| title_fullStr |
Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting |
| title_full_unstemmed |
Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting |
| title_sort |
large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/9d695a233ef54642ace9e04ed24b5883 |
| work_keys_str_mv |
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