Repeated injury promotes tracheobronchial tissue stem cell attrition

Repeated injury promotes tracheobronchial tissue stem cell attrition

Abstract Chronic lung disease has been attributed to stem cell aging and/or exhaustion. We investigated these mechanisms using mouse and human tracheobronchial tissue‐specific stem cells (TSC). In mouse, chromatin labeling and flow cytometry demonstrated that naphthalene (NA) injury activated a subs...

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Bibliographic Details
Main Authors: Moumita Ghosh, Cynthia L. Hill, Alfahdah Alsudayri, Scott W. Lallier, Don Hayes Jr., Saranga Wijeratne, Zhang Hong Tan, Tendy Chiang, John E. Mahoney, Gianni Carraro, Barry R. Stripp, Susan D. Reynolds
Format: article
Language:EN
Published: Wiley 2021
Subjects:
airway epithelial stem cell
basal cell
biological aging
chronic lung disease
Medicine (General)
R5-920
Cytology
QH573-671
Online Access:https://doaj.org/article/9d6a17e6e3c24ef9bf31f1af6b2661cd
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https://doaj.org/article/9d6a17e6e3c24ef9bf31f1af6b2661cd

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