Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture
Hepatitis B virus (HBV) infection and DNA integration is a frequent cause of hepatocellular carcinoma (HCC), but the consequences of this process are not fully understood. Here the authors use whole-genome and long-read sequencing data from HCC patient samples to study the timing and alterations ind...
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Nature Portfolio
2021
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oai:doaj.org-article:9d6ae04fdf164e1683ea18005b4462b32021-11-28T12:35:57ZAberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture10.1038/s41467-021-26805-82041-1723https://doaj.org/article/9d6ae04fdf164e1683ea18005b4462b32021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26805-8https://doaj.org/toc/2041-1723Hepatitis B virus (HBV) infection and DNA integration is a frequent cause of hepatocellular carcinoma (HCC), but the consequences of this process are not fully understood. Here the authors use whole-genome and long-read sequencing data from HCC patient samples to study the timing and alterations induced by HBV insertions.Eva G. ÁlvarezJonas DemeulemeesterPaula OteroClemency JollyDaniel García-SoutoAna Pequeño-ValtierraJorge ZamoraMarta TojoJavier TemesAdrian Baez-OrtegaBernardo Rodriguez-MartinAna OitabenAlicia L. BruzosMónica Martínez-FernándezKerstin HaaseSonia ZumalaveRosanna AbalJorge Rodríguez-CastroAitor Rodriguez-CasanovaAngel Diaz-LagaresYilong LiKeiran M. RaineAdam P. ButlerIago OteroAtsushi OnoHiroshi AikataKazuaki ChayamaMasaki UenoShinya HayamiHiroki YamaueKazuhiro MaejimaMiguel G. BlancoXavier FornsCarmen RivasJuan Ruiz-BañobreSofía Pérez-del-PulgarRaúl Torres-RuizSandra Rodriguez-PeralesUrtzi GaraigortaPeter J. CampbellHidewaki NakagawaPeter Van LooJose M. C. TubioNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
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DOAJ |
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EN |
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Science Q Eva G. Álvarez Jonas Demeulemeester Paula Otero Clemency Jolly Daniel García-Souto Ana Pequeño-Valtierra Jorge Zamora Marta Tojo Javier Temes Adrian Baez-Ortega Bernardo Rodriguez-Martin Ana Oitaben Alicia L. Bruzos Mónica Martínez-Fernández Kerstin Haase Sonia Zumalave Rosanna Abal Jorge Rodríguez-Castro Aitor Rodriguez-Casanova Angel Diaz-Lagares Yilong Li Keiran M. Raine Adam P. Butler Iago Otero Atsushi Ono Hiroshi Aikata Kazuaki Chayama Masaki Ueno Shinya Hayami Hiroki Yamaue Kazuhiro Maejima Miguel G. Blanco Xavier Forns Carmen Rivas Juan Ruiz-Bañobre Sofía Pérez-del-Pulgar Raúl Torres-Ruiz Sandra Rodriguez-Perales Urtzi Garaigorta Peter J. Campbell Hidewaki Nakagawa Peter Van Loo Jose M. C. Tubio Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture |
| description |
Hepatitis B virus (HBV) infection and DNA integration is a frequent cause of hepatocellular carcinoma (HCC), but the consequences of this process are not fully understood. Here the authors use whole-genome and long-read sequencing data from HCC patient samples to study the timing and alterations induced by HBV insertions. |
| format |
article |
| author |
Eva G. Álvarez Jonas Demeulemeester Paula Otero Clemency Jolly Daniel García-Souto Ana Pequeño-Valtierra Jorge Zamora Marta Tojo Javier Temes Adrian Baez-Ortega Bernardo Rodriguez-Martin Ana Oitaben Alicia L. Bruzos Mónica Martínez-Fernández Kerstin Haase Sonia Zumalave Rosanna Abal Jorge Rodríguez-Castro Aitor Rodriguez-Casanova Angel Diaz-Lagares Yilong Li Keiran M. Raine Adam P. Butler Iago Otero Atsushi Ono Hiroshi Aikata Kazuaki Chayama Masaki Ueno Shinya Hayami Hiroki Yamaue Kazuhiro Maejima Miguel G. Blanco Xavier Forns Carmen Rivas Juan Ruiz-Bañobre Sofía Pérez-del-Pulgar Raúl Torres-Ruiz Sandra Rodriguez-Perales Urtzi Garaigorta Peter J. Campbell Hidewaki Nakagawa Peter Van Loo Jose M. C. Tubio |
| author_facet |
Eva G. Álvarez Jonas Demeulemeester Paula Otero Clemency Jolly Daniel García-Souto Ana Pequeño-Valtierra Jorge Zamora Marta Tojo Javier Temes Adrian Baez-Ortega Bernardo Rodriguez-Martin Ana Oitaben Alicia L. Bruzos Mónica Martínez-Fernández Kerstin Haase Sonia Zumalave Rosanna Abal Jorge Rodríguez-Castro Aitor Rodriguez-Casanova Angel Diaz-Lagares Yilong Li Keiran M. Raine Adam P. Butler Iago Otero Atsushi Ono Hiroshi Aikata Kazuaki Chayama Masaki Ueno Shinya Hayami Hiroki Yamaue Kazuhiro Maejima Miguel G. Blanco Xavier Forns Carmen Rivas Juan Ruiz-Bañobre Sofía Pérez-del-Pulgar Raúl Torres-Ruiz Sandra Rodriguez-Perales Urtzi Garaigorta Peter J. Campbell Hidewaki Nakagawa Peter Van Loo Jose M. C. Tubio |
| author_sort |
Eva G. Álvarez |
| title |
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture |
| title_short |
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture |
| title_full |
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture |
| title_fullStr |
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture |
| title_full_unstemmed |
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture |
| title_sort |
aberrant integration of hepatitis b virus dna promotes major restructuring of human hepatocellular carcinoma genome architecture |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/9d6ae04fdf164e1683ea18005b4462b3 |
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