Electronic and electrochemical viral detection for point-of-care use: A systematic review.

Detecting viruses, which have significant impact on health and the economy, is essential for controlling and combating viral infections. In recent years there has been a focus towards simpler and faster detection methods, specifically through the use of electronic-based detection at the point-of-car...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Solen Monteil, Alexander J Casson, Samuel T Jones
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9d6b3864d2a241fcb101d0b6a0de3f5a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9d6b3864d2a241fcb101d0b6a0de3f5a
record_format	dspace
spelling	oai:doaj.org-article:9d6b3864d2a241fcb101d0b6a0de3f5a2021-12-02T20:13:55ZElectronic and electrochemical viral detection for point-of-care use: A systematic review.1932-620310.1371/journal.pone.0258002https://doaj.org/article/9d6b3864d2a241fcb101d0b6a0de3f5a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258002https://doaj.org/toc/1932-6203Detecting viruses, which have significant impact on health and the economy, is essential for controlling and combating viral infections. In recent years there has been a focus towards simpler and faster detection methods, specifically through the use of electronic-based detection at the point-of-care. Point-of-care sensors play a particularly important role in the detection of viruses. Tests can be performed in the field or in resource limited regions in a simple manner and short time frame, allowing for rapid treatment. Electronic based detection allows for speed and quantitative detection not otherwise possible at the point-of-care. Such approaches are largely based upon voltammetry, electrochemical impedance spectroscopy, field effect transistors, and similar electrical techniques. Here, we systematically review electronic and electrochemical point-of-care sensors for the detection of human viral pathogens. Using the reported limits of detection and assay times we compare approaches both by detection method and by the target analyte of interest. Compared to recent scoping and narrative reviews, this systematic review which follows established best practice for evidence synthesis adds substantial new evidence on 1) performance and 2) limitations, needed for sensor uptake in the clinical arena. 104 relevant studies were identified by conducting a search of current literature using 7 databases, only including original research articles detecting human viruses and reporting a limit of detection. Detection units were converted to nanomolars where possible in order to compare performance across devices. This approach allows us to identify field effect transistors as having the fastest median response time, and as being the most sensitive, some achieving single-molecule detection. In general, we found that antigens are the quickest targets to detect. We also observe however, that reports are highly variable in their chosen metrics of interest. We suggest that this lack of systematisation across studies may be a major bottleneck in sensor development and translation. Where appropriate, we use the findings of the systematic review to give recommendations for best reporting practice.Solen MonteilAlexander J CassonSamuel T JonesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0258002 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Solen Monteil Alexander J Casson Samuel T Jones Electronic and electrochemical viral detection for point-of-care use: A systematic review.
description	Detecting viruses, which have significant impact on health and the economy, is essential for controlling and combating viral infections. In recent years there has been a focus towards simpler and faster detection methods, specifically through the use of electronic-based detection at the point-of-care. Point-of-care sensors play a particularly important role in the detection of viruses. Tests can be performed in the field or in resource limited regions in a simple manner and short time frame, allowing for rapid treatment. Electronic based detection allows for speed and quantitative detection not otherwise possible at the point-of-care. Such approaches are largely based upon voltammetry, electrochemical impedance spectroscopy, field effect transistors, and similar electrical techniques. Here, we systematically review electronic and electrochemical point-of-care sensors for the detection of human viral pathogens. Using the reported limits of detection and assay times we compare approaches both by detection method and by the target analyte of interest. Compared to recent scoping and narrative reviews, this systematic review which follows established best practice for evidence synthesis adds substantial new evidence on 1) performance and 2) limitations, needed for sensor uptake in the clinical arena. 104 relevant studies were identified by conducting a search of current literature using 7 databases, only including original research articles detecting human viruses and reporting a limit of detection. Detection units were converted to nanomolars where possible in order to compare performance across devices. This approach allows us to identify field effect transistors as having the fastest median response time, and as being the most sensitive, some achieving single-molecule detection. In general, we found that antigens are the quickest targets to detect. We also observe however, that reports are highly variable in their chosen metrics of interest. We suggest that this lack of systematisation across studies may be a major bottleneck in sensor development and translation. Where appropriate, we use the findings of the systematic review to give recommendations for best reporting practice.
format	article
author	Solen Monteil Alexander J Casson Samuel T Jones
author_facet	Solen Monteil Alexander J Casson Samuel T Jones
author_sort	Solen Monteil
title	Electronic and electrochemical viral detection for point-of-care use: A systematic review.
title_short	Electronic and electrochemical viral detection for point-of-care use: A systematic review.
title_full	Electronic and electrochemical viral detection for point-of-care use: A systematic review.
title_fullStr	Electronic and electrochemical viral detection for point-of-care use: A systematic review.
title_full_unstemmed	Electronic and electrochemical viral detection for point-of-care use: A systematic review.
title_sort	electronic and electrochemical viral detection for point-of-care use: a systematic review.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9d6b3864d2a241fcb101d0b6a0de3f5a
work_keys_str_mv	AT solenmonteil electronicandelectrochemicalviraldetectionforpointofcareuseasystematicreview AT alexanderjcasson electronicandelectrochemicalviraldetectionforpointofcareuseasystematicreview AT samueltjones electronicandelectrochemicalviraldetectionforpointofcareuseasystematicreview
_version_	1718374723145957376

Electronic and electrochemical viral detection for point-of-care use: A systematic review.

Ejemplares similares