Disrupting self-evaluative processing with electrostimulation mapping during awake brain surgery

Abstract Brain awake surgery with cognitive monitoring for tumor removal has become a standard of treatment for functional purpose. Yet, little attention has been given to patients’ interpretation and awareness of their own responses to selected cognitive tasks during direct electrostimulation (DES)...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sam Ng, Guillaume Herbet, Anne-Laure Lemaitre, Sylvie Moritz-Gasser, Hugues Duffau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9d72bfa910fc439dbc27d999d26206ca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9d72bfa910fc439dbc27d999d26206ca
record_format	dspace
spelling	oai:doaj.org-article:9d72bfa910fc439dbc27d999d26206ca2021-12-02T17:15:17ZDisrupting self-evaluative processing with electrostimulation mapping during awake brain surgery10.1038/s41598-021-88916-y2045-2322https://doaj.org/article/9d72bfa910fc439dbc27d999d26206ca2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88916-yhttps://doaj.org/toc/2045-2322Abstract Brain awake surgery with cognitive monitoring for tumor removal has become a standard of treatment for functional purpose. Yet, little attention has been given to patients’ interpretation and awareness of their own responses to selected cognitive tasks during direct electrostimulation (DES). We aim to report disruptions of self-evaluative processing evoked by DES during awake surgery. We further investigate cortico-subcortical structures involved in self-assessment process and report the use of an intraoperative self-assessment tool, the self-confidence index (SCI). Seventy-two patients who had undergone awake brain tumor resections were selected. Inclusion criteria were the occurrence of a DES-induced disruption of an ongoing task followed by patient’s failure to remember or criticize these impairments, or a dissociation between patient’s responses to an ongoing task and patient’s SCI. Disruptions of self-evaluation were frequently associated with semantic disorders and critical sites were mostly found along the left/right ventral semantic streams. Disconnectome analyses generated from a tractography-based atlas confirmed the high probability of the inferior fronto-occipital fasciculus to be transitory ‘disconnected’. These findings suggest that white matters pathways belonging to the ventral semantic stream may be critically involved in human self-evaluative processing. Finally, the authors discuss the implementation of the SCI task during multimodal intraoperative monitoring.Sam NgGuillaume HerbetAnne-Laure LemaitreSylvie Moritz-GasserHugues DuffauNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sam Ng Guillaume Herbet Anne-Laure Lemaitre Sylvie Moritz-Gasser Hugues Duffau Disrupting self-evaluative processing with electrostimulation mapping during awake brain surgery
description	Abstract Brain awake surgery with cognitive monitoring for tumor removal has become a standard of treatment for functional purpose. Yet, little attention has been given to patients’ interpretation and awareness of their own responses to selected cognitive tasks during direct electrostimulation (DES). We aim to report disruptions of self-evaluative processing evoked by DES during awake surgery. We further investigate cortico-subcortical structures involved in self-assessment process and report the use of an intraoperative self-assessment tool, the self-confidence index (SCI). Seventy-two patients who had undergone awake brain tumor resections were selected. Inclusion criteria were the occurrence of a DES-induced disruption of an ongoing task followed by patient’s failure to remember or criticize these impairments, or a dissociation between patient’s responses to an ongoing task and patient’s SCI. Disruptions of self-evaluation were frequently associated with semantic disorders and critical sites were mostly found along the left/right ventral semantic streams. Disconnectome analyses generated from a tractography-based atlas confirmed the high probability of the inferior fronto-occipital fasciculus to be transitory ‘disconnected’. These findings suggest that white matters pathways belonging to the ventral semantic stream may be critically involved in human self-evaluative processing. Finally, the authors discuss the implementation of the SCI task during multimodal intraoperative monitoring.
format	article
author	Sam Ng Guillaume Herbet Anne-Laure Lemaitre Sylvie Moritz-Gasser Hugues Duffau
author_facet	Sam Ng Guillaume Herbet Anne-Laure Lemaitre Sylvie Moritz-Gasser Hugues Duffau
author_sort	Sam Ng
title	Disrupting self-evaluative processing with electrostimulation mapping during awake brain surgery
title_short	Disrupting self-evaluative processing with electrostimulation mapping during awake brain surgery
title_full	Disrupting self-evaluative processing with electrostimulation mapping during awake brain surgery
title_fullStr	Disrupting self-evaluative processing with electrostimulation mapping during awake brain surgery
title_full_unstemmed	Disrupting self-evaluative processing with electrostimulation mapping during awake brain surgery
title_sort	disrupting self-evaluative processing with electrostimulation mapping during awake brain surgery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9d72bfa910fc439dbc27d999d26206ca
work_keys_str_mv	AT samng disruptingselfevaluativeprocessingwithelectrostimulationmappingduringawakebrainsurgery AT guillaumeherbet disruptingselfevaluativeprocessingwithelectrostimulationmappingduringawakebrainsurgery AT annelaurelemaitre disruptingselfevaluativeprocessingwithelectrostimulationmappingduringawakebrainsurgery AT sylviemoritzgasser disruptingselfevaluativeprocessingwithelectrostimulationmappingduringawakebrainsurgery AT huguesduffau disruptingselfevaluativeprocessingwithelectrostimulationmappingduringawakebrainsurgery
_version_	1718381276311846912

Disrupting self-evaluative processing with electrostimulation mapping during awake brain surgery

Ejemplares similares