Stem cell horizons in intervertebral disc degeneration

Joseph Ciacci1, Allen Ho1,2, Christopher P Ames3, Rahul Jandial41Division of Neurosurgery, University of California, San Diego, La Jolla, California, USA; 2Del E Webb Neurosciences, Aging and Stem Cell Research Center, The Burnham Institute for Medical Research, La Jolla, California, USA; 3Departmen...

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Autores principales:	Joseph Ciacci, Allen Ho, Christopher P Ames, Rahul Jandial
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/9d777daf92f44020969bddd9231de66c
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spelling	oai:doaj.org-article:9d777daf92f44020969bddd9231de66c2021-12-02T00:28:31ZStem cell horizons in intervertebral disc degeneration1178-6957https://doaj.org/article/9d777daf92f44020969bddd9231de66c2009-01-01T00:00:00Zhttp://www.dovepress.com/stem-cell-horizons-in-intervertebral-disc-degeneration-a2798https://doaj.org/toc/1178-6957Joseph Ciacci1, Allen Ho1,2, Christopher P Ames3, Rahul Jandial41Division of Neurosurgery, University of California, San Diego, La Jolla, California, USA; 2Del E Webb Neurosciences, Aging and Stem Cell Research Center, The Burnham Institute for Medical Research, La Jolla, California, USA; 3Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; 4Division of Neurosurgery, Department of Surgery, City of Hope Cancer Center, Duarte, CA, USAAbstract: Intervertebral disc degeneration remains a pervasive and intractable disease arising from a combination of aging and stress on the back and spine. The growing field of regenerative medicine brings the promise of stem cells in the treatment of disc disease. Scientists and physicians hope to employ stem cells not only to stop, but also reverse degeneration. However, there are many important outstanding issues, including the hostile avascular, apoptotic physiological environment of the intervertebral disc, and the difficulty of obtaining mesenchymal stem cells, and directing them towards chondrocytic differentiation and integration within the nucleus pulposus of the disc. Given the recent advances in minimally invasive spine surgery, and developing body of work on stem cell manipulation and transplantation, stem cells are uniquely poised to bring about large-scale improvements in treatment and outcomes for degenerative disc disease. In this review we will first discuss the cellular and molecular factors influencing degeneration, and then examine the efficacy and difficulties of stem cell transplantation.Keywords: intervertebral disc degeneration, stem cells, disc disease, mesenchymal stem cells, stem cell transplantation Joseph CiacciAllen HoChristopher P AmesRahul JandialDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2008, Iss default, Pp 31-39 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Joseph Ciacci Allen Ho Christopher P Ames Rahul Jandial Stem cell horizons in intervertebral disc degeneration
description	Joseph Ciacci1, Allen Ho1,2, Christopher P Ames3, Rahul Jandial41Division of Neurosurgery, University of California, San Diego, La Jolla, California, USA; 2Del E Webb Neurosciences, Aging and Stem Cell Research Center, The Burnham Institute for Medical Research, La Jolla, California, USA; 3Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; 4Division of Neurosurgery, Department of Surgery, City of Hope Cancer Center, Duarte, CA, USAAbstract: Intervertebral disc degeneration remains a pervasive and intractable disease arising from a combination of aging and stress on the back and spine. The growing field of regenerative medicine brings the promise of stem cells in the treatment of disc disease. Scientists and physicians hope to employ stem cells not only to stop, but also reverse degeneration. However, there are many important outstanding issues, including the hostile avascular, apoptotic physiological environment of the intervertebral disc, and the difficulty of obtaining mesenchymal stem cells, and directing them towards chondrocytic differentiation and integration within the nucleus pulposus of the disc. Given the recent advances in minimally invasive spine surgery, and developing body of work on stem cell manipulation and transplantation, stem cells are uniquely poised to bring about large-scale improvements in treatment and outcomes for degenerative disc disease. In this review we will first discuss the cellular and molecular factors influencing degeneration, and then examine the efficacy and difficulties of stem cell transplantation.Keywords: intervertebral disc degeneration, stem cells, disc disease, mesenchymal stem cells, stem cell transplantation
format	article
author	Joseph Ciacci Allen Ho Christopher P Ames Rahul Jandial
author_facet	Joseph Ciacci Allen Ho Christopher P Ames Rahul Jandial
author_sort	Joseph Ciacci
title	Stem cell horizons in intervertebral disc degeneration
title_short	Stem cell horizons in intervertebral disc degeneration
title_full	Stem cell horizons in intervertebral disc degeneration
title_fullStr	Stem cell horizons in intervertebral disc degeneration
title_full_unstemmed	Stem cell horizons in intervertebral disc degeneration
title_sort	stem cell horizons in intervertebral disc degeneration
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/9d777daf92f44020969bddd9231de66c
work_keys_str_mv	AT josephciacci stemcellhorizonsinintervertebraldiscdegeneration AT allenho stemcellhorizonsinintervertebraldiscdegeneration AT christopherpames stemcellhorizonsinintervertebraldiscdegeneration AT rahuljandial stemcellhorizonsinintervertebraldiscdegeneration
_version_	1718403693765722112

Stem cell horizons in intervertebral disc degeneration

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