Bioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy

Qiong Ma,1 Xi Zhao,1 Anhua Shi,1 Junzi Wu1,2 1The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, People’s Republic of China; 2Department of Medical Biology, College of Basic Medicine, Yu...

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Autores principales:	Ma Q, Zhao X, Shi A, Wu J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	phenylboronic acid glucose sensitive diabetes Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9d7bc60c8daa4367a2c3d8288500ee43
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spelling	oai:doaj.org-article:9d7bc60c8daa4367a2c3d8288500ee432021-12-02T13:57:47ZBioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy1178-2013https://doaj.org/article/9d7bc60c8daa4367a2c3d8288500ee432021-01-01T00:00:00Zhttps://www.dovepress.com/bioresponsive-functional-phenylboronic-acid-based-delivery-system-as-a-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Qiong Ma,1 Xi Zhao,1 Anhua Shi,1 Junzi Wu1,2 1The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, People’s Republic of China; 2Department of Medical Biology, College of Basic Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, People’s Republic of ChinaCorrespondence: Junzi Wu; Anhua ShiYunnan University of Chinese Medicine, No. 1076, Yuhua Road, Chenggong District, Kunming, Yunnan 650500, People’s Republic of ChinaTel/Fax +86 187 8855 7524Email beached@126.com; 2697349858@qq.comAbstract: The glucose-sensitive self-adjusting drug delivery system simulates the physiological model of the human pancreas-secreting insulin and then precisely regulates the release of hypoglycemic drugs and controls the blood sugar. Thus, it has good application prospects in the treatment of diabetes. Presently, there are three glucose-sensitive drug systems: phenylboronic acid (PBA) and its derivatives, concanavalin A (Con A), and glucose oxidase (GOD). Among these, the glucose-sensitive polymer carrier based on PBA has the advantages of better stability, long-term storage, and reversible glucose response, and the loading of insulin in it can achieve the controlled release of drugs in the human environment. Therefore, it has become a research hotspot in recent years and has been developed very rapidly. In order to further carry out a follow-up study, we focused on the development process, performance, and application of PBA and its derivatives-based glucose-sensitive polymer drug carriers, and the prospects for the development of this field.Keywords: phenylboronic acid, glucose sensitive, diabetesMa QZhao XShi AWu JDove Medical Pressarticlephenylboronic acidglucose sensitivediabetesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 297-314 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	phenylboronic acid glucose sensitive diabetes Medicine (General) R5-920
spellingShingle	phenylboronic acid glucose sensitive diabetes Medicine (General) R5-920 Ma Q Zhao X Shi A Wu J Bioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy
description	Qiong Ma,1 Xi Zhao,1 Anhua Shi,1 Junzi Wu1,2 1The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, People’s Republic of China; 2Department of Medical Biology, College of Basic Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, People’s Republic of ChinaCorrespondence: Junzi Wu; Anhua ShiYunnan University of Chinese Medicine, No. 1076, Yuhua Road, Chenggong District, Kunming, Yunnan 650500, People’s Republic of ChinaTel/Fax +86 187 8855 7524Email beached@126.com; 2697349858@qq.comAbstract: The glucose-sensitive self-adjusting drug delivery system simulates the physiological model of the human pancreas-secreting insulin and then precisely regulates the release of hypoglycemic drugs and controls the blood sugar. Thus, it has good application prospects in the treatment of diabetes. Presently, there are three glucose-sensitive drug systems: phenylboronic acid (PBA) and its derivatives, concanavalin A (Con A), and glucose oxidase (GOD). Among these, the glucose-sensitive polymer carrier based on PBA has the advantages of better stability, long-term storage, and reversible glucose response, and the loading of insulin in it can achieve the controlled release of drugs in the human environment. Therefore, it has become a research hotspot in recent years and has been developed very rapidly. In order to further carry out a follow-up study, we focused on the development process, performance, and application of PBA and its derivatives-based glucose-sensitive polymer drug carriers, and the prospects for the development of this field.Keywords: phenylboronic acid, glucose sensitive, diabetes
format	article
author	Ma Q Zhao X Shi A Wu J
author_facet	Ma Q Zhao X Shi A Wu J
author_sort	Ma Q
title	Bioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy
title_short	Bioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy
title_full	Bioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy
title_fullStr	Bioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy
title_full_unstemmed	Bioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy
title_sort	bioresponsive functional phenylboronic acid-based delivery system as an emerging platform for diabetic therapy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/9d7bc60c8daa4367a2c3d8288500ee43
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Bioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy

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