Common data elements for predictors of pediatric sepsis: A framework to standardize data collection.

<h4>Background</h4>Standardized collection of predictors of pediatric sepsis has enormous potential to increase data compatibility across research studies. The Pediatric Sepsis Predictor Standardization Working Group collaborated to define common data elements for pediatric sepsis predic...

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Autores principales:	Alishah Mawji, Edmond Li, Arjun Chandna, Teresa Kortz, Samuel Akech, Matthew O Wiens, Niranjan Kissoon, Mark Ansermino
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9d7ef9cd70d246939ea73130d4470cc4
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spelling	oai:doaj.org-article:9d7ef9cd70d246939ea73130d4470cc42021-12-02T20:10:47ZCommon data elements for predictors of pediatric sepsis: A framework to standardize data collection.1932-620310.1371/journal.pone.0253051https://doaj.org/article/9d7ef9cd70d246939ea73130d4470cc42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253051https://doaj.org/toc/1932-6203<h4>Background</h4>Standardized collection of predictors of pediatric sepsis has enormous potential to increase data compatibility across research studies. The Pediatric Sepsis Predictor Standardization Working Group collaborated to define common data elements for pediatric sepsis predictors at the point of triage to serve as a standardized framework for data collection in resource-limited settings.<h4>Methods</h4>A preliminary list of pediatric sepsis predictor variables was compiled through a systematic literature review and examination of global guideline documents. A 5-round modified Delphi that involved independent voting and active group discussions was conducted to select, standardize, and prioritize predictors. Considerations included the perceived predictive value of the candidate predictor at the point of triage, intra- and inter-rater measurement reliability, and the amount of time and material resources required to reliably collect the predictor in resource-limited settings.<h4>Results</h4>We generated 116 common data elements for implementation in future studies. Each common data element includes a standardized prompt, suggested response values, and prioritization as tier 1 (essential), tier 2 (important), or tier 3 (exploratory). Branching logic was added to the predictors list to facilitate the design of efficient data collection methods, such as low-cost electronic case report forms on a mobile application. The set of common data elements are freely available on the Pediatric Sepsis CoLab Dataverse and a web-based feedback survey is available through the Pediatric Sepsis CoLab. Updated iterations will continuously be released based on feedback from the pediatric sepsis research community and emergence of new information.<h4>Conclusion</h4>Routine use of the common data elements in future studies can allow data sharing between studies and contribute to development of powerful risk prediction algorithms. These algorithms may then be used to support clinical decision making at triage in resource-limited settings. Continued collaboration, engagement, and feedback from the pediatric sepsis research community will be important to ensure the common data elements remain applicable across a broad range of geographical and sociocultural settings.Alishah MawjiEdmond LiArjun ChandnaTeresa KortzSamuel AkechMatthew O WiensNiranjan KissoonMark AnserminoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253051 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alishah Mawji Edmond Li Arjun Chandna Teresa Kortz Samuel Akech Matthew O Wiens Niranjan Kissoon Mark Ansermino Common data elements for predictors of pediatric sepsis: A framework to standardize data collection.
description	<h4>Background</h4>Standardized collection of predictors of pediatric sepsis has enormous potential to increase data compatibility across research studies. The Pediatric Sepsis Predictor Standardization Working Group collaborated to define common data elements for pediatric sepsis predictors at the point of triage to serve as a standardized framework for data collection in resource-limited settings.<h4>Methods</h4>A preliminary list of pediatric sepsis predictor variables was compiled through a systematic literature review and examination of global guideline documents. A 5-round modified Delphi that involved independent voting and active group discussions was conducted to select, standardize, and prioritize predictors. Considerations included the perceived predictive value of the candidate predictor at the point of triage, intra- and inter-rater measurement reliability, and the amount of time and material resources required to reliably collect the predictor in resource-limited settings.<h4>Results</h4>We generated 116 common data elements for implementation in future studies. Each common data element includes a standardized prompt, suggested response values, and prioritization as tier 1 (essential), tier 2 (important), or tier 3 (exploratory). Branching logic was added to the predictors list to facilitate the design of efficient data collection methods, such as low-cost electronic case report forms on a mobile application. The set of common data elements are freely available on the Pediatric Sepsis CoLab Dataverse and a web-based feedback survey is available through the Pediatric Sepsis CoLab. Updated iterations will continuously be released based on feedback from the pediatric sepsis research community and emergence of new information.<h4>Conclusion</h4>Routine use of the common data elements in future studies can allow data sharing between studies and contribute to development of powerful risk prediction algorithms. These algorithms may then be used to support clinical decision making at triage in resource-limited settings. Continued collaboration, engagement, and feedback from the pediatric sepsis research community will be important to ensure the common data elements remain applicable across a broad range of geographical and sociocultural settings.
format	article
author	Alishah Mawji Edmond Li Arjun Chandna Teresa Kortz Samuel Akech Matthew O Wiens Niranjan Kissoon Mark Ansermino
author_facet	Alishah Mawji Edmond Li Arjun Chandna Teresa Kortz Samuel Akech Matthew O Wiens Niranjan Kissoon Mark Ansermino
author_sort	Alishah Mawji
title	Common data elements for predictors of pediatric sepsis: A framework to standardize data collection.
title_short	Common data elements for predictors of pediatric sepsis: A framework to standardize data collection.
title_full	Common data elements for predictors of pediatric sepsis: A framework to standardize data collection.
title_fullStr	Common data elements for predictors of pediatric sepsis: A framework to standardize data collection.
title_full_unstemmed	Common data elements for predictors of pediatric sepsis: A framework to standardize data collection.
title_sort	common data elements for predictors of pediatric sepsis: a framework to standardize data collection.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9d7ef9cd70d246939ea73130d4470cc4
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Common data elements for predictors of pediatric sepsis: A framework to standardize data collection.

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