Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population

Ci Yan,1 Li Duan,1 Chunfeng Fu,1 Chunsheng Tian,1 Bihui Zhang,1 Xiaojun Shao,1 Gang Zhu1,2 1Department of Psychiatry, The First Afﬁliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Department of Central Laboratory, The First Affiliated Hospital of C...

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Autores principales:	Yan C, Duan L, Fu C, Tian C, Zhang B, Shao X, Zhu G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	glutathione transferase gene polymorphisms schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9d818f46e1f1461ab712f3660b6cb7f7
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spelling	oai:doaj.org-article:9d818f46e1f1461ab712f3660b6cb7f72021-12-02T09:18:56ZAssociation Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population1178-2021https://doaj.org/article/9d818f46e1f1461ab712f3660b6cb7f72020-02-01T00:00:00Zhttps://www.dovepress.com/association-between-glutathione-s-transferase-gst-polymorphisms-and-sc-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ci Yan,1 Li Duan,1 Chunfeng Fu,1 Chunsheng Tian,1 Bihui Zhang,1 Xiaojun Shao,1 Gang Zhu1,2 1Department of Psychiatry, The First Afﬁliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Department of Central Laboratory, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of ChinaCorrespondence: Gang ZhuDepartment of Psychiatry, The First Afﬁliated Hospital of China Medical University, Shenyang 110001, People’s Republic of ChinaTel/Fax +86 248 328 2184Email gzhu@cmu.edu.cnBackground: Glutathione S-transferase (GST) is an important antioxidant enzyme in the body. The weakening of the antioxidant system causes damage to the cells and tissues that make up the organism, adversely affects the function of the nervous system, and ultimately leads to schizophrenia (SCZ). Previous studies have yielded inconsistent results across different ethnic populations.Purpose: This case–control study was carried out to investigate whether genetic polymorphisms in GST could be associated with SCZ in the Chinese Han population.Patients and Methods: A total of 794 participants, including 379 SCZ patients (case group) and 415 healthy individuals (control group), were genotyped by polymerase chain reaction-restriction fragment length for polymorphisms in GST genes.Results: The study found that the frequency of the GSTM1 null genotype was higher in case group than control group (p=0.003). The frequency of the GSTM1 and GSTT1 double null genotype was also higher in case group than control group (p=0.008).Conclusion: We conclude that the GSTM1 null genotype and the GSTM1 and GSTT1 double null genotype may be related to the onset of SCZ in Chinese Han population.Keywords: glutathione transferase, gene polymorphisms, schizophreniaYan CDuan LFu CTian CZhang BShao XZhu GDove Medical Pressarticleglutathione transferasegene polymorphismsschizophreniaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 479-487 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	glutathione transferase gene polymorphisms schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	glutathione transferase gene polymorphisms schizophrenia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yan C Duan L Fu C Tian C Zhang B Shao X Zhu G Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population
description	Ci Yan,1 Li Duan,1 Chunfeng Fu,1 Chunsheng Tian,1 Bihui Zhang,1 Xiaojun Shao,1 Gang Zhu1,2 1Department of Psychiatry, The First Afﬁliated Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Department of Central Laboratory, The First Affiliated Hospital of China Medical University, Shenyang 110001, People’s Republic of ChinaCorrespondence: Gang ZhuDepartment of Psychiatry, The First Afﬁliated Hospital of China Medical University, Shenyang 110001, People’s Republic of ChinaTel/Fax +86 248 328 2184Email gzhu@cmu.edu.cnBackground: Glutathione S-transferase (GST) is an important antioxidant enzyme in the body. The weakening of the antioxidant system causes damage to the cells and tissues that make up the organism, adversely affects the function of the nervous system, and ultimately leads to schizophrenia (SCZ). Previous studies have yielded inconsistent results across different ethnic populations.Purpose: This case–control study was carried out to investigate whether genetic polymorphisms in GST could be associated with SCZ in the Chinese Han population.Patients and Methods: A total of 794 participants, including 379 SCZ patients (case group) and 415 healthy individuals (control group), were genotyped by polymerase chain reaction-restriction fragment length for polymorphisms in GST genes.Results: The study found that the frequency of the GSTM1 null genotype was higher in case group than control group (p=0.003). The frequency of the GSTM1 and GSTT1 double null genotype was also higher in case group than control group (p=0.008).Conclusion: We conclude that the GSTM1 null genotype and the GSTM1 and GSTT1 double null genotype may be related to the onset of SCZ in Chinese Han population.Keywords: glutathione transferase, gene polymorphisms, schizophrenia
format	article
author	Yan C Duan L Fu C Tian C Zhang B Shao X Zhu G
author_facet	Yan C Duan L Fu C Tian C Zhang B Shao X Zhu G
author_sort	Yan C
title	Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population
title_short	Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population
title_full	Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population
title_fullStr	Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population
title_full_unstemmed	Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population
title_sort	association between glutathione s-transferase (gst) polymorphisms and schizophrenia in a chinese han population
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/9d818f46e1f1461ab712f3660b6cb7f7
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Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population

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