Variable structure and function relationship of compressive optic neuropathy at the time of diagnosis

Poramaet Laowanapiban,1,2 Niphon Chirapapaisan,1 Sumitra Kemahayung,1 Mathuwan Srikong11Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Ophthalmology Service, Mettapracharak (Wat Rai Khing) Hospital, Nakhon Pathom, ThailandCorrespondence: Ni...

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Autores principales: Laowanapiban P, Chirapapaisan N, Kemahayung S, Srikong M
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Publicado: Dove Medical Press 2019
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spelling oai:doaj.org-article:9d82386029a24b86b04f1116f957612b2021-12-02T07:40:33ZVariable structure and function relationship of compressive optic neuropathy at the time of diagnosis1177-5483https://doaj.org/article/9d82386029a24b86b04f1116f957612b2019-08-01T00:00:00Zhttps://www.dovepress.com/variable-structure-and-function-relationship-of-compressive-optic-neur-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Poramaet Laowanapiban,1,2 Niphon Chirapapaisan,1 Sumitra Kemahayung,1 Mathuwan Srikong11Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Ophthalmology Service, Mettapracharak (Wat Rai Khing) Hospital, Nakhon Pathom, ThailandCorrespondence: Niphon ChirapapaisanDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Siriraj, Bangkoknoi, Bangkok 10700, ThailandTel +66 02 419 8033Fax +66 02 411 1906Email niphon.chi@mahidol.ac.thPurpose: To illustrate the structure–function relationship of compressive optic neuropathy (CON) at the time of diagnosis.Patients and methods: Thirty-two eyes of newly diagnosed suprasellar CON and 60 healthy eyes were included in the study. The peripapillary retinal nerve fiber layer (RNFL) thickness and macular ganglion cell-inner plexiform layer (GCIPL) thickness were obtained using Cirrus spectral domain optical coherence tomography (SD-OCT). CON eyes were stratified based on the similar degree and pattern of both RNFL and GCIPL.Results: From 32 eyes of newly diagnosed suprasellar CON eyes, 27 eyes had a predominantly nasal hemiretina thinning of macular GCIPL, 4 eyes showed a generalized macular thinning, and 1 eye showed a predominantly superior macular thinning. The corresponding temporal peripapillary RNFL thinning with nasal hemiretina GCIPL thinning were inconsistently manifested. Structure–function analysis of stratified CON eyes with similar thinning profiles showed that a range rather than a fixed value of visual field loss based on mean deviation (MD) index was associated to each thinning profile. The maximal limit of visual field loss range was ubiquitously nonrestricted to any structural thinning profile. While the minimal limit of the associated MD range was gradually reduced from 0 to about −16.0 dB, the nasal hemiretina macular GCIPL thinning was the only manifestation and decreased from 75 to 45 μm. However, the different degrees of temporal hemiretina macular GCIPL and superior–inferior peripapillary RNFL thinning were only seen in 10 of 32 eyes of which their nasal hemiretina GCIPL and temporal RNFL thinning had reached significant thinning. Interestingly when present, the minimal limit of associated MD range continued to decrease from −16.0 to −32.0 dB.Conclusion: CON eyes can present with variable structure and function relationship at the time of diagnosis. Using structural parameters at the time of diagnosis to predict the prognosis should be used with caution.Keywords: peripapillary retinal nerve fiber layer, macular ganglion cell-inner plexiform layer, optical coherence tomography, suprasellar massLaowanapiban PChirapapaisan NKemahayung SSrikong MDove Medical Pressarticleperipapillary retinal nerve fiber layermacular ganglion cell-inner plexiform layeroptical coherence tomographysuprasellar mass.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1599-1608 (2019)
institution DOAJ
collection DOAJ
language EN
topic peripapillary retinal nerve fiber layer
macular ganglion cell-inner plexiform layer
optical coherence tomography
suprasellar mass.
Ophthalmology
RE1-994
spellingShingle peripapillary retinal nerve fiber layer
macular ganglion cell-inner plexiform layer
optical coherence tomography
suprasellar mass.
Ophthalmology
RE1-994
Laowanapiban P
Chirapapaisan N
Kemahayung S
Srikong M
Variable structure and function relationship of compressive optic neuropathy at the time of diagnosis
description Poramaet Laowanapiban,1,2 Niphon Chirapapaisan,1 Sumitra Kemahayung,1 Mathuwan Srikong11Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Ophthalmology Service, Mettapracharak (Wat Rai Khing) Hospital, Nakhon Pathom, ThailandCorrespondence: Niphon ChirapapaisanDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Siriraj, Bangkoknoi, Bangkok 10700, ThailandTel +66 02 419 8033Fax +66 02 411 1906Email niphon.chi@mahidol.ac.thPurpose: To illustrate the structure–function relationship of compressive optic neuropathy (CON) at the time of diagnosis.Patients and methods: Thirty-two eyes of newly diagnosed suprasellar CON and 60 healthy eyes were included in the study. The peripapillary retinal nerve fiber layer (RNFL) thickness and macular ganglion cell-inner plexiform layer (GCIPL) thickness were obtained using Cirrus spectral domain optical coherence tomography (SD-OCT). CON eyes were stratified based on the similar degree and pattern of both RNFL and GCIPL.Results: From 32 eyes of newly diagnosed suprasellar CON eyes, 27 eyes had a predominantly nasal hemiretina thinning of macular GCIPL, 4 eyes showed a generalized macular thinning, and 1 eye showed a predominantly superior macular thinning. The corresponding temporal peripapillary RNFL thinning with nasal hemiretina GCIPL thinning were inconsistently manifested. Structure–function analysis of stratified CON eyes with similar thinning profiles showed that a range rather than a fixed value of visual field loss based on mean deviation (MD) index was associated to each thinning profile. The maximal limit of visual field loss range was ubiquitously nonrestricted to any structural thinning profile. While the minimal limit of the associated MD range was gradually reduced from 0 to about −16.0 dB, the nasal hemiretina macular GCIPL thinning was the only manifestation and decreased from 75 to 45 μm. However, the different degrees of temporal hemiretina macular GCIPL and superior–inferior peripapillary RNFL thinning were only seen in 10 of 32 eyes of which their nasal hemiretina GCIPL and temporal RNFL thinning had reached significant thinning. Interestingly when present, the minimal limit of associated MD range continued to decrease from −16.0 to −32.0 dB.Conclusion: CON eyes can present with variable structure and function relationship at the time of diagnosis. Using structural parameters at the time of diagnosis to predict the prognosis should be used with caution.Keywords: peripapillary retinal nerve fiber layer, macular ganglion cell-inner plexiform layer, optical coherence tomography, suprasellar mass
format article
author Laowanapiban P
Chirapapaisan N
Kemahayung S
Srikong M
author_facet Laowanapiban P
Chirapapaisan N
Kemahayung S
Srikong M
author_sort Laowanapiban P
title Variable structure and function relationship of compressive optic neuropathy at the time of diagnosis
title_short Variable structure and function relationship of compressive optic neuropathy at the time of diagnosis
title_full Variable structure and function relationship of compressive optic neuropathy at the time of diagnosis
title_fullStr Variable structure and function relationship of compressive optic neuropathy at the time of diagnosis
title_full_unstemmed Variable structure and function relationship of compressive optic neuropathy at the time of diagnosis
title_sort variable structure and function relationship of compressive optic neuropathy at the time of diagnosis
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/9d82386029a24b86b04f1116f957612b
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AT kemahayungs variablestructureandfunctionrelationshipofcompressiveopticneuropathyatthetimeofdiagnosis
AT srikongm variablestructureandfunctionrelationshipofcompressiveopticneuropathyatthetimeofdiagnosis
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