Fascin in Gynecological Cancers: An Update of the Literature

Fascin is an actin-binding protein that is encoded by the <i>FSCN1</i> gene (located on chromosome 7). It triggers membrane projections and stimulates cell motility in cancer cells. Fascin overexpression has been described in different types of human cancers in which its expression corre...

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Autores principales:	Ishita Gupta, Semir Vranic, Hamda Al-Thawadi, Ala-Eddin Al Moustafa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	fascin gynecological cancer ovarian cancer cervical cancer biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/9d88c7e189eb4429850c425e0440cc1a
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id	oai:doaj.org-article:9d88c7e189eb4429850c425e0440cc1a
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spelling	oai:doaj.org-article:9d88c7e189eb4429850c425e0440cc1a2021-11-25T17:03:37ZFascin in Gynecological Cancers: An Update of the Literature10.3390/cancers132257602072-6694https://doaj.org/article/9d88c7e189eb4429850c425e0440cc1a2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5760https://doaj.org/toc/2072-6694Fascin is an actin-binding protein that is encoded by the <i>FSCN1</i> gene (located on chromosome 7). It triggers membrane projections and stimulates cell motility in cancer cells. Fascin overexpression has been described in different types of human cancers in which its expression correlated with tumor growth, migration, invasion, and metastasis. Moreover, overexpression of fascin was found in oncovirus-infected cells, such as human papillomaviruses (HPVs) and Epstein-Barr virus (EBV), disrupting the cell–cell adhesion and enhancing cancer progression. Based on these findings, several studies reported fascin as a potential biomarker and a therapeutic target in various cancers. This review provides a brief overview of the FSCN1 role in various cancers with emphasis on gynecological malignancies. We also discuss fascin interactions with other genes and oncoviruses through which it might induce cancer development and progression.Ishita GuptaSemir VranicHamda Al-ThawadiAla-Eddin Al MoustafaMDPI AGarticlefascingynecological cancerovarian cancercervical cancerbiomarkerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5760, p 5760 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fascin gynecological cancer ovarian cancer cervical cancer biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	fascin gynecological cancer ovarian cancer cervical cancer biomarker Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ishita Gupta Semir Vranic Hamda Al-Thawadi Ala-Eddin Al Moustafa Fascin in Gynecological Cancers: An Update of the Literature
description	Fascin is an actin-binding protein that is encoded by the <i>FSCN1</i> gene (located on chromosome 7). It triggers membrane projections and stimulates cell motility in cancer cells. Fascin overexpression has been described in different types of human cancers in which its expression correlated with tumor growth, migration, invasion, and metastasis. Moreover, overexpression of fascin was found in oncovirus-infected cells, such as human papillomaviruses (HPVs) and Epstein-Barr virus (EBV), disrupting the cell–cell adhesion and enhancing cancer progression. Based on these findings, several studies reported fascin as a potential biomarker and a therapeutic target in various cancers. This review provides a brief overview of the FSCN1 role in various cancers with emphasis on gynecological malignancies. We also discuss fascin interactions with other genes and oncoviruses through which it might induce cancer development and progression.
format	article
author	Ishita Gupta Semir Vranic Hamda Al-Thawadi Ala-Eddin Al Moustafa
author_facet	Ishita Gupta Semir Vranic Hamda Al-Thawadi Ala-Eddin Al Moustafa
author_sort	Ishita Gupta
title	Fascin in Gynecological Cancers: An Update of the Literature
title_short	Fascin in Gynecological Cancers: An Update of the Literature
title_full	Fascin in Gynecological Cancers: An Update of the Literature
title_fullStr	Fascin in Gynecological Cancers: An Update of the Literature
title_full_unstemmed	Fascin in Gynecological Cancers: An Update of the Literature
title_sort	fascin in gynecological cancers: an update of the literature
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9d88c7e189eb4429850c425e0440cc1a
work_keys_str_mv	AT ishitagupta fasciningynecologicalcancersanupdateoftheliterature AT semirvranic fasciningynecologicalcancersanupdateoftheliterature AT hamdaalthawadi fasciningynecologicalcancersanupdateoftheliterature AT alaeddinalmoustafa fasciningynecologicalcancersanupdateoftheliterature
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Fascin in Gynecological Cancers: An Update of the Literature

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