Mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects

Lilach Toker,1 Galila Agam2,3 1Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada; 2Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel; 3Mental Health Center, Beer-Sheva, Israel Abstract: Cumulating evidence for...

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Autores principales:	Toker L, Agam G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9d8de12cec6f4f17b7f8a31ca45b8931
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spelling	oai:doaj.org-article:9d8de12cec6f4f17b7f8a31ca45b89312021-12-02T01:23:13ZMitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects1178-2021https://doaj.org/article/9d8de12cec6f4f17b7f8a31ca45b89312015-09-01T00:00:00Zhttps://www.dovepress.com/mitochondrial-dysfunction-in-psychiatric-morbidity-current-evidence-an-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Lilach Toker,1 Galila Agam2,3 1Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada; 2Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel; 3Mental Health Center, Beer-Sheva, Israel Abstract: Cumulating evidence for the involvement of mitochondrial dysfunction in psychiatric disorders leaves little to no doubt regarding the involvement of this pathology in mood disorders. However, mitochondrial abnormalities are also observed in a wide range of disorders spanning from cancer and diabetes to various neurodegenerative and neurodevelopmental disorders such as Parkinson’s, Alzheimer’s, Huntington’s, autism, and amyotrophic lateral sclerosis. The apparent lack of specificity questions the role of mitochondrial dysfunction in psychiatric disorders, in general, and in mood disorders, in particular. Is mitochondrial dysfunction a general phenomenon, simplistically rendering brain cells to be more vulnerable to a variety of disease-specific perturbations? Or is it an epiphenomenon induced by various disease-specific factors? Or possibly, the severity and the anatomical region of the dysfunction are the ones responsible for the distinct features of the disorders. Whichever of the aforementioned ones, if any, is correct, “mitochondrial dysfunction” became more of a cliché than a therapeutic target. In this review, we summarize current studies supporting the involvement of mitochondrial dysfunction in different psychiatric disorders. We address the question of specificity and causality of the different findings and provide an alternative explanation for some of the aforementioned questions. Keywords: bipolar disorder, psychiatric disorders, schizophrenia, Stanley Foundation Brain CollectionToker LAgam GDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2441-2447 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Toker L Agam G Mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects
description	Lilach Toker,1 Galila Agam2,3 1Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada; 2Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer-Sheva, Israel; 3Mental Health Center, Beer-Sheva, Israel Abstract: Cumulating evidence for the involvement of mitochondrial dysfunction in psychiatric disorders leaves little to no doubt regarding the involvement of this pathology in mood disorders. However, mitochondrial abnormalities are also observed in a wide range of disorders spanning from cancer and diabetes to various neurodegenerative and neurodevelopmental disorders such as Parkinson’s, Alzheimer’s, Huntington’s, autism, and amyotrophic lateral sclerosis. The apparent lack of specificity questions the role of mitochondrial dysfunction in psychiatric disorders, in general, and in mood disorders, in particular. Is mitochondrial dysfunction a general phenomenon, simplistically rendering brain cells to be more vulnerable to a variety of disease-specific perturbations? Or is it an epiphenomenon induced by various disease-specific factors? Or possibly, the severity and the anatomical region of the dysfunction are the ones responsible for the distinct features of the disorders. Whichever of the aforementioned ones, if any, is correct, “mitochondrial dysfunction” became more of a cliché than a therapeutic target. In this review, we summarize current studies supporting the involvement of mitochondrial dysfunction in different psychiatric disorders. We address the question of specificity and causality of the different findings and provide an alternative explanation for some of the aforementioned questions. Keywords: bipolar disorder, psychiatric disorders, schizophrenia, Stanley Foundation Brain Collection
format	article
author	Toker L Agam G
author_facet	Toker L Agam G
author_sort	Toker L
title	Mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects
title_short	Mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects
title_full	Mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects
title_fullStr	Mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects
title_full_unstemmed	Mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects
title_sort	mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/9d8de12cec6f4f17b7f8a31ca45b8931
work_keys_str_mv	AT tokerl mitochondrialdysfunctioninpsychiatricmorbiditycurrentevidenceandtherapeuticprospects AT agamg mitochondrialdysfunctioninpsychiatricmorbiditycurrentevidenceandtherapeuticprospects
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Mitochondrial dysfunction in psychiatric morbidity: current evidence and therapeutic prospects

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