Pig genome functional annotation enhances the biological interpretation of complex traits and human disease

Annotating functional elements of the genome helps the interpretation of genetic variation. Here, the authors compile functional genomics data for the pig genome over 14 tissues with 15 different chromatin states, integrate the data with WGS and GWAS data, and compare conservation of regulatory elem...

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Autores principales:	Zhangyuan Pan, Yuelin Yao, Hongwei Yin, Zexi Cai, Ying Wang, Lijing Bai, Colin Kern, Michelle Halstead, Ganrea Chanthavixay, Nares Trakooljul, Klaus Wimmers, Goutam Sahana, Guosheng Su, Mogens Sandø Lund, Merete Fredholm, Peter Karlskov-Mortensen, Catherine W. Ernst, Pablo Ross, Christopher K. Tuggle, Lingzhao Fang, Huaijun Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9d93bfd836f04f2482675331b406ee47
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spelling	oai:doaj.org-article:9d93bfd836f04f2482675331b406ee472021-12-02T18:01:53ZPig genome functional annotation enhances the biological interpretation of complex traits and human disease10.1038/s41467-021-26153-72041-1723https://doaj.org/article/9d93bfd836f04f2482675331b406ee472021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26153-7https://doaj.org/toc/2041-1723Annotating functional elements of the genome helps the interpretation of genetic variation. Here, the authors compile functional genomics data for the pig genome over 14 tissues with 15 different chromatin states, integrate the data with WGS and GWAS data, and compare conservation of regulatory elements across mouse and human tissues.Zhangyuan PanYuelin YaoHongwei YinZexi CaiYing WangLijing BaiColin KernMichelle HalsteadGanrea ChanthavixayNares TrakooljulKlaus WimmersGoutam SahanaGuosheng SuMogens Sandø LundMerete FredholmPeter Karlskov-MortensenCatherine W. ErnstPablo RossChristopher K. TuggleLingzhao FangHuaijun ZhouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhangyuan Pan Yuelin Yao Hongwei Yin Zexi Cai Ying Wang Lijing Bai Colin Kern Michelle Halstead Ganrea Chanthavixay Nares Trakooljul Klaus Wimmers Goutam Sahana Guosheng Su Mogens Sandø Lund Merete Fredholm Peter Karlskov-Mortensen Catherine W. Ernst Pablo Ross Christopher K. Tuggle Lingzhao Fang Huaijun Zhou Pig genome functional annotation enhances the biological interpretation of complex traits and human disease
description	Annotating functional elements of the genome helps the interpretation of genetic variation. Here, the authors compile functional genomics data for the pig genome over 14 tissues with 15 different chromatin states, integrate the data with WGS and GWAS data, and compare conservation of regulatory elements across mouse and human tissues.
format	article
author	Zhangyuan Pan Yuelin Yao Hongwei Yin Zexi Cai Ying Wang Lijing Bai Colin Kern Michelle Halstead Ganrea Chanthavixay Nares Trakooljul Klaus Wimmers Goutam Sahana Guosheng Su Mogens Sandø Lund Merete Fredholm Peter Karlskov-Mortensen Catherine W. Ernst Pablo Ross Christopher K. Tuggle Lingzhao Fang Huaijun Zhou
author_facet	Zhangyuan Pan Yuelin Yao Hongwei Yin Zexi Cai Ying Wang Lijing Bai Colin Kern Michelle Halstead Ganrea Chanthavixay Nares Trakooljul Klaus Wimmers Goutam Sahana Guosheng Su Mogens Sandø Lund Merete Fredholm Peter Karlskov-Mortensen Catherine W. Ernst Pablo Ross Christopher K. Tuggle Lingzhao Fang Huaijun Zhou
author_sort	Zhangyuan Pan
title	Pig genome functional annotation enhances the biological interpretation of complex traits and human disease
title_short	Pig genome functional annotation enhances the biological interpretation of complex traits and human disease
title_full	Pig genome functional annotation enhances the biological interpretation of complex traits and human disease
title_fullStr	Pig genome functional annotation enhances the biological interpretation of complex traits and human disease
title_full_unstemmed	Pig genome functional annotation enhances the biological interpretation of complex traits and human disease
title_sort	pig genome functional annotation enhances the biological interpretation of complex traits and human disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9d93bfd836f04f2482675331b406ee47
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Pig genome functional annotation enhances the biological interpretation of complex traits and human disease

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