Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

The cellular mechanisms underlying autophagy are conserved; however it is unclear how they evolved in higher organisms. Here the authors identify two oxidation-sensitive cysteine residues in the autophagy receptor SQSTM1/p62 in vertebrates which allow activation of pro-survival autophagy in stress c...

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Autores principales:	Bernadette Carroll, Elsje G. Otten, Diego Manni, Rhoda Stefanatos, Fiona M. Menzies, Graham R. Smith, Diana Jurk, Niall Kenneth, Simon Wilkinson, Joao F. Passos, Johannes Attems, Elizabeth A. Veal, Elisa Teyssou, Danielle Seilhean, Stéphanie Millecamps, Eeva-Liisa Eskelinen, Agnieszka K. Bronowska, David C. Rubinsztein, Alberto Sanz, Viktor I. Korolchuk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9d95b336540a41c68ad4e7b54566d6ac
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spelling	oai:doaj.org-article:9d95b336540a41c68ad4e7b54566d6ac2021-12-02T17:33:16ZOxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis10.1038/s41467-017-02746-z2041-1723https://doaj.org/article/9d95b336540a41c68ad4e7b54566d6ac2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02746-zhttps://doaj.org/toc/2041-1723The cellular mechanisms underlying autophagy are conserved; however it is unclear how they evolved in higher organisms. Here the authors identify two oxidation-sensitive cysteine residues in the autophagy receptor SQSTM1/p62 in vertebrates which allow activation of pro-survival autophagy in stress conditions.Bernadette CarrollElsje G. OttenDiego ManniRhoda StefanatosFiona M. MenziesGraham R. SmithDiana JurkNiall KennethSimon WilkinsonJoao F. PassosJohannes AttemsElizabeth A. VealElisa TeyssouDanielle SeilheanStéphanie MillecampsEeva-Liisa EskelinenAgnieszka K. BronowskaDavid C. RubinszteinAlberto SanzViktor I. KorolchukNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bernadette Carroll Elsje G. Otten Diego Manni Rhoda Stefanatos Fiona M. Menzies Graham R. Smith Diana Jurk Niall Kenneth Simon Wilkinson Joao F. Passos Johannes Attems Elizabeth A. Veal Elisa Teyssou Danielle Seilhean Stéphanie Millecamps Eeva-Liisa Eskelinen Agnieszka K. Bronowska David C. Rubinsztein Alberto Sanz Viktor I. Korolchuk Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis
description	The cellular mechanisms underlying autophagy are conserved; however it is unclear how they evolved in higher organisms. Here the authors identify two oxidation-sensitive cysteine residues in the autophagy receptor SQSTM1/p62 in vertebrates which allow activation of pro-survival autophagy in stress conditions.
format	article
author	Bernadette Carroll Elsje G. Otten Diego Manni Rhoda Stefanatos Fiona M. Menzies Graham R. Smith Diana Jurk Niall Kenneth Simon Wilkinson Joao F. Passos Johannes Attems Elizabeth A. Veal Elisa Teyssou Danielle Seilhean Stéphanie Millecamps Eeva-Liisa Eskelinen Agnieszka K. Bronowska David C. Rubinsztein Alberto Sanz Viktor I. Korolchuk
author_facet	Bernadette Carroll Elsje G. Otten Diego Manni Rhoda Stefanatos Fiona M. Menzies Graham R. Smith Diana Jurk Niall Kenneth Simon Wilkinson Joao F. Passos Johannes Attems Elizabeth A. Veal Elisa Teyssou Danielle Seilhean Stéphanie Millecamps Eeva-Liisa Eskelinen Agnieszka K. Bronowska David C. Rubinsztein Alberto Sanz Viktor I. Korolchuk
author_sort	Bernadette Carroll
title	Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis
title_short	Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis
title_full	Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis
title_fullStr	Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis
title_full_unstemmed	Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis
title_sort	oxidation of sqstm1/p62 mediates the link between redox state and protein homeostasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9d95b336540a41c68ad4e7b54566d6ac
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Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis

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