Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis
The cellular mechanisms underlying autophagy are conserved; however it is unclear how they evolved in higher organisms. Here the authors identify two oxidation-sensitive cysteine residues in the autophagy receptor SQSTM1/p62 in vertebrates which allow activation of pro-survival autophagy in stress c...
Saved in:
Main Authors: | Bernadette Carroll, Elsje G. Otten, Diego Manni, Rhoda Stefanatos, Fiona M. Menzies, Graham R. Smith, Diana Jurk, Niall Kenneth, Simon Wilkinson, Joao F. Passos, Johannes Attems, Elizabeth A. Veal, Elisa Teyssou, Danielle Seilhean, Stéphanie Millecamps, Eeva-Liisa Eskelinen, Agnieszka K. Bronowska, David C. Rubinsztein, Alberto Sanz, Viktor I. Korolchuk |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2018
|
Subjects: | |
Online Access: | https://doaj.org/article/9d95b336540a41c68ad4e7b54566d6ac |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
ZZ-dependent regulation of p62/SQSTM1 in autophagy
by: Yi Zhang, et al.
Published: (2018) -
Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake
by: Arjen J. Jakobi, et al.
Published: (2020) -
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates
by: David Schlütermann, et al.
Published: (2021) -
Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter
by: Do Hoon Kwon, et al.
Published: (2018) -
Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates
by: Fernando Bartolome, et al.
Published: (2017)