Effects of Celecoxib Adjunct to Selective Serotonin Reuptake Inhibitors on Obsessive-Compulsive Disorder

Introduction: Inflammatory processes in the brain play an important role in the etiopathogenesis of Obsessive-Compulsive Disorder (OCD). Cyclooxygenase inhibitors, such as celecoxib reduce the production of proinflammatory cytokines. This double-blind study aimed to investigate the effects of adding...

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Autores principales:	Najmeh Shahini, Ali Talaei, Mohammadreza Shalbafan, Farhad Faridhosseini, Malihe Ziaee
Formato:	article
Lenguaje:	EN
Publicado:	Iran University of Medical Sciences 2021
Materias:	celecoxib clinical trial selective serotonin reuptake inhibitor (ssri) obsessive-compulsive disorder (ocd) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/9d9819043d47446a8d8a40c6615caa35
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spelling	oai:doaj.org-article:9d9819043d47446a8d8a40c6615caa352021-12-05T08:43:44ZEffects of Celecoxib Adjunct to Selective Serotonin Reuptake Inhibitors on Obsessive-Compulsive Disorder2008-126X2228-7442https://doaj.org/article/9d9819043d47446a8d8a40c6615caa352021-07-01T00:00:00Zhttp://bcn.iums.ac.ir/article-1-1587-en.htmlhttps://doaj.org/toc/2008-126Xhttps://doaj.org/toc/2228-7442Introduction: Inflammatory processes in the brain play an important role in the etiopathogenesis of Obsessive-Compulsive Disorder (OCD). Cyclooxygenase inhibitors, such as celecoxib reduce the production of proinflammatory cytokines. This double-blind study aimed to investigate the effects of adding celecoxib to Selective Serotonin Reuptake Inhibitors (SSRIs)on treating OCD. Methods: Sixty patients who met the diagnosis criteria for OCD based on the Diagnostic and Statistical Manual of Mental Disorders -Fourth Edition- Text Revision (DSM-IV-TR) were recruited in the present study. Two psychiatrists independently confirmed the diagnosis by performing structured interviews. The study participants included 23 patients who received SSRIs and celecoxib (400 mg twice daily) and 22 patients in the control group that received SSRIs and placebo. Moreover, at baseline, in weeks 4, 8, and 12, the explored patients were assessed by a psychiatrist using the Yale-Brown Obsessive-Compulsive Scale (Y-BCOS). Results: A significant difference was observed in the change of scores on the Y-BOCS in week 12, compared with the onset of the study between the study groups (t= -8.976, df=38, P=0.001). There was a significant difference between the study groups in obsession (F= 49.19, df= 1, P≤0.001), compulsion (F= 13.78, df= 1, P= 0.001), and OCD (F= 57.25, df= 1, P≤0.001), i.e., higher in the celecoxib group. Conclusion: This study showed that adjuvant treatment with celecoxib can further improve the symptoms of OCD in individuals receiving SSRIs.Najmeh ShahiniAli TalaeiMohammadreza ShalbafanFarhad FaridhosseiniMalihe ZiaeeIran University of Medical Sciencesarticlecelecoxibclinical trialselective serotonin reuptake inhibitor (ssri)obsessive-compulsive disorder (ocd)Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBasic and Clinical Neuroscience, Vol 12, Iss 4, Pp 489-498 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	celecoxib clinical trial selective serotonin reuptake inhibitor (ssri) obsessive-compulsive disorder (ocd) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	celecoxib clinical trial selective serotonin reuptake inhibitor (ssri) obsessive-compulsive disorder (ocd) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Najmeh Shahini Ali Talaei Mohammadreza Shalbafan Farhad Faridhosseini Malihe Ziaee Effects of Celecoxib Adjunct to Selective Serotonin Reuptake Inhibitors on Obsessive-Compulsive Disorder
description	Introduction: Inflammatory processes in the brain play an important role in the etiopathogenesis of Obsessive-Compulsive Disorder (OCD). Cyclooxygenase inhibitors, such as celecoxib reduce the production of proinflammatory cytokines. This double-blind study aimed to investigate the effects of adding celecoxib to Selective Serotonin Reuptake Inhibitors (SSRIs)on treating OCD. Methods: Sixty patients who met the diagnosis criteria for OCD based on the Diagnostic and Statistical Manual of Mental Disorders -Fourth Edition- Text Revision (DSM-IV-TR) were recruited in the present study. Two psychiatrists independently confirmed the diagnosis by performing structured interviews. The study participants included 23 patients who received SSRIs and celecoxib (400 mg twice daily) and 22 patients in the control group that received SSRIs and placebo. Moreover, at baseline, in weeks 4, 8, and 12, the explored patients were assessed by a psychiatrist using the Yale-Brown Obsessive-Compulsive Scale (Y-BCOS). Results: A significant difference was observed in the change of scores on the Y-BOCS in week 12, compared with the onset of the study between the study groups (t= -8.976, df=38, P=0.001). There was a significant difference between the study groups in obsession (F= 49.19, df= 1, P≤0.001), compulsion (F= 13.78, df= 1, P= 0.001), and OCD (F= 57.25, df= 1, P≤0.001), i.e., higher in the celecoxib group. Conclusion: This study showed that adjuvant treatment with celecoxib can further improve the symptoms of OCD in individuals receiving SSRIs.
format	article
author	Najmeh Shahini Ali Talaei Mohammadreza Shalbafan Farhad Faridhosseini Malihe Ziaee
author_facet	Najmeh Shahini Ali Talaei Mohammadreza Shalbafan Farhad Faridhosseini Malihe Ziaee
author_sort	Najmeh Shahini
title	Effects of Celecoxib Adjunct to Selective Serotonin Reuptake Inhibitors on Obsessive-Compulsive Disorder
title_short	Effects of Celecoxib Adjunct to Selective Serotonin Reuptake Inhibitors on Obsessive-Compulsive Disorder
title_full	Effects of Celecoxib Adjunct to Selective Serotonin Reuptake Inhibitors on Obsessive-Compulsive Disorder
title_fullStr	Effects of Celecoxib Adjunct to Selective Serotonin Reuptake Inhibitors on Obsessive-Compulsive Disorder
title_full_unstemmed	Effects of Celecoxib Adjunct to Selective Serotonin Reuptake Inhibitors on Obsessive-Compulsive Disorder
title_sort	effects of celecoxib adjunct to selective serotonin reuptake inhibitors on obsessive-compulsive disorder
publisher	Iran University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/9d9819043d47446a8d8a40c6615caa35
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Effects of Celecoxib Adjunct to Selective Serotonin Reuptake Inhibitors on Obsessive-Compulsive Disorder

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