The relationship between pre-treatment heart rate variability and response to low-frequency accelerated repetitive transcranial magnetic stimulation in major depression

Background: Major depressive disorder (MDD) is now the first cause of disability worldwide. So far, no validated and scalable biomarker has been identified to help with response prediction to antidepressant treatment. Cardiac biomarkers such as heart rate variability (HRV) have been studied in MDD,...

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Autores principales:	Jean-Philippe Miron, Jack Sheen, Tony Panzarella, Molly Hyde, Farrokh Mansouri, Linsay Fox, Helena Voetterl, Véronique Desbeaumes Jodoin, Paul Lespérance, Christophe Longpré-Poirier, Robert-Paul Juster, Zafiris J. Daskalakis, Daniel M. Blumberger, Jonathan Downar
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Heart rate variability HRV MDD Prediction Accelerated arTMS Mental healing RZ400-408
Acceso en línea:	https://doaj.org/article/9d9a209d80e948cb9895811235782a47
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spelling	oai:doaj.org-article:9d9a209d80e948cb9895811235782a472021-11-18T04:53:37ZThe relationship between pre-treatment heart rate variability and response to low-frequency accelerated repetitive transcranial magnetic stimulation in major depression2666-915310.1016/j.jadr.2021.100270https://doaj.org/article/9d9a209d80e948cb9895811235782a472021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S266691532100192Xhttps://doaj.org/toc/2666-9153Background: Major depressive disorder (MDD) is now the first cause of disability worldwide. So far, no validated and scalable biomarker has been identified to help with response prediction to antidepressant treatment. Cardiac biomarkers such as heart rate variability (HRV) have been studied in MDD, but few studies have examined its potential use for outcome prediction to repetitive transcranial magnetic stimulation (rTMS). Objective: We recorded pre-treatment HRV in MDD participants prior to an rTMS course. We hypothesized that higher pre-treatment HRV would be correlated with better clinical outcomes. Methods: HRV was recorded as part of a single-arm, open-label rTMS feasibility study. Pre-treatment HRV was assessed in N = 30 MDD participants before they underwent a one-week (5 days, 8 daily sessions, 40 sessions total) accelerated rTMS (arTMS) course using a low-frequency 1 Hz course (600 pulses per session, 50-minute intersession interval) over the right dorsolateral prefrontal cortex at 120% of the resting motor threshold. Clinical outcomes were captured using the Beck Depression Inventory-II (BDI-II). We tested for an association between pre-treatment HRV and clinical outcomes on the BDI-II using a linear mixed effects model. Results: Although average BDI-II score significantly changed over time, these changes were not significantly associated with pre-treatment HRV (p = 0.60). This finding remained when adjusting for age, sex, and HR, individually and collectively. Conclusion: The current study did not find a relationship between pre-treatment HRV and response to low frequency rTMS. Other approaches using cardiac biomarkers may have potential for response prediction.Jean-Philippe MironJack SheenTony PanzarellaMolly HydeFarrokh MansouriLinsay FoxHelena VoetterlVéronique Desbeaumes JodoinPaul LespéranceChristophe Longpré-PoirierRobert-Paul JusterZafiris J. DaskalakisDaniel M. BlumbergerJonathan DownarElsevierarticleHeart rate variabilityHRVMDDPredictionAcceleratedarTMSMental healingRZ400-408ENJournal of Affective Disorders Reports, Vol 6, Iss , Pp 100270- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Heart rate variability HRV MDD Prediction Accelerated arTMS Mental healing RZ400-408
spellingShingle	Heart rate variability HRV MDD Prediction Accelerated arTMS Mental healing RZ400-408 Jean-Philippe Miron Jack Sheen Tony Panzarella Molly Hyde Farrokh Mansouri Linsay Fox Helena Voetterl Véronique Desbeaumes Jodoin Paul Lespérance Christophe Longpré-Poirier Robert-Paul Juster Zafiris J. Daskalakis Daniel M. Blumberger Jonathan Downar The relationship between pre-treatment heart rate variability and response to low-frequency accelerated repetitive transcranial magnetic stimulation in major depression
description	Background: Major depressive disorder (MDD) is now the first cause of disability worldwide. So far, no validated and scalable biomarker has been identified to help with response prediction to antidepressant treatment. Cardiac biomarkers such as heart rate variability (HRV) have been studied in MDD, but few studies have examined its potential use for outcome prediction to repetitive transcranial magnetic stimulation (rTMS). Objective: We recorded pre-treatment HRV in MDD participants prior to an rTMS course. We hypothesized that higher pre-treatment HRV would be correlated with better clinical outcomes. Methods: HRV was recorded as part of a single-arm, open-label rTMS feasibility study. Pre-treatment HRV was assessed in N = 30 MDD participants before they underwent a one-week (5 days, 8 daily sessions, 40 sessions total) accelerated rTMS (arTMS) course using a low-frequency 1 Hz course (600 pulses per session, 50-minute intersession interval) over the right dorsolateral prefrontal cortex at 120% of the resting motor threshold. Clinical outcomes were captured using the Beck Depression Inventory-II (BDI-II). We tested for an association between pre-treatment HRV and clinical outcomes on the BDI-II using a linear mixed effects model. Results: Although average BDI-II score significantly changed over time, these changes were not significantly associated with pre-treatment HRV (p = 0.60). This finding remained when adjusting for age, sex, and HR, individually and collectively. Conclusion: The current study did not find a relationship between pre-treatment HRV and response to low frequency rTMS. Other approaches using cardiac biomarkers may have potential for response prediction.
format	article
author	Jean-Philippe Miron Jack Sheen Tony Panzarella Molly Hyde Farrokh Mansouri Linsay Fox Helena Voetterl Véronique Desbeaumes Jodoin Paul Lespérance Christophe Longpré-Poirier Robert-Paul Juster Zafiris J. Daskalakis Daniel M. Blumberger Jonathan Downar
author_facet	Jean-Philippe Miron Jack Sheen Tony Panzarella Molly Hyde Farrokh Mansouri Linsay Fox Helena Voetterl Véronique Desbeaumes Jodoin Paul Lespérance Christophe Longpré-Poirier Robert-Paul Juster Zafiris J. Daskalakis Daniel M. Blumberger Jonathan Downar
author_sort	Jean-Philippe Miron
title	The relationship between pre-treatment heart rate variability and response to low-frequency accelerated repetitive transcranial magnetic stimulation in major depression
title_short	The relationship between pre-treatment heart rate variability and response to low-frequency accelerated repetitive transcranial magnetic stimulation in major depression
title_full	The relationship between pre-treatment heart rate variability and response to low-frequency accelerated repetitive transcranial magnetic stimulation in major depression
title_fullStr	The relationship between pre-treatment heart rate variability and response to low-frequency accelerated repetitive transcranial magnetic stimulation in major depression
title_full_unstemmed	The relationship between pre-treatment heart rate variability and response to low-frequency accelerated repetitive transcranial magnetic stimulation in major depression
title_sort	relationship between pre-treatment heart rate variability and response to low-frequency accelerated repetitive transcranial magnetic stimulation in major depression
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9d9a209d80e948cb9895811235782a47
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The relationship between pre-treatment heart rate variability and response to low-frequency accelerated repetitive transcranial magnetic stimulation in major depression

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