ASH1L histone methyltransferase regulates the handoff between damage recognition factors in global-genome nucleotide excision repair

ASH1L histone methyltransferase regulates the handoff between damage recognition factors in global-genome nucleotide excision repair

UV-induced mutagenic cyclobutane pyrimidine dimers on nucleosomal DNA are sensed by the damage recognition factors DDB2 and XPC via an unknown mechanism. Here, the authors show that the histone methyltransferase ASH1L regulates the DDB2 to XPC handoff by methylating Lys-4 of histone H3.

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Autores principales: Chiara Balbo Pogliano, Marco Gatti, Peter Rüthemann, Zuzana Garajovà, Lorenza Penengo, Hanspeter Naegeli
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/9d9aa0b04f364233b240cfb6b9393ea7
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