Prognosis of nontuberculous mycobacterial pulmonary disease according to the method of microbiologic diagnosis

Abstract Microbiological criteria for nontuberculous mycobacterial pulmonary disease (NTM-PD) require cultures from two separate sputum or one non-sputum specimen. However, there is limited data on the progression of NTM-PD following non-sputum culture-based diagnosis. We compared the disease progre...

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Autores principales:	Sooim Sin, Seungchul Han, Yeon Joo Lee, Young-jae Cho, Jong Sun Park, Ho Il Yoon, Choon-Taek Lee, Jae Ho Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9d9f1ac4372b42039d44283506774fb1
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spelling	oai:doaj.org-article:9d9f1ac4372b42039d44283506774fb12021-12-02T14:26:25ZPrognosis of nontuberculous mycobacterial pulmonary disease according to the method of microbiologic diagnosis10.1038/s41598-021-87197-92045-2322https://doaj.org/article/9d9f1ac4372b42039d44283506774fb12021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87197-9https://doaj.org/toc/2045-2322Abstract Microbiological criteria for nontuberculous mycobacterial pulmonary disease (NTM-PD) require cultures from two separate sputum or one non-sputum specimen. However, there is limited data on the progression of NTM-PD following non-sputum culture-based diagnosis. We compared the disease progression of NTM-PD diagnosed with non-sputum vs sputum cultures. We included 833 patients and divided them into sputum NTM isolation (n = 123), sputum NTM-PD (n = 558), and non-sputum NTM-PD groups (n = 152). Disease progression, defined as radiographic aggravation and therapy initiation, was compared between groups. The median observation time was 60.5 months (interquartile range, 31.4–96.0). The non-sputum NTM-PD group showed longer treatment-free survival (log-rank test; p = 0.009) and lower risk of treatment (adjusted hazard ratio [aHR] of sputum NTM-PD group, 1.36; 95% confidence interval (CI), 1.01–1.84) than the sputum NTM-PD group. The non-sputum NTM-PD group showed longer radiographic aggravation-free survival (Log-rank test; p = 0.015) and lower risk of radiographic aggravation (aHR of sputum NTM-PD group, 1.52; 95% CI, 1.06–2.19) than the sputum NTM-PD group. NTM-PD diagnosed using methods other than sputum culture showed a low risk of disease progression and progressed slower than NTM-PD diagnosed from a sputum culture. NTM-PD diagnosed using methods other than sputum culture may be a mild disease, not equivalent to NTM-PD diagnosed from sputum culture.Sooim SinSeungchul HanYeon Joo LeeYoung-jae ChoJong Sun ParkHo Il YoonChoon-Taek LeeJae Ho LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sooim Sin Seungchul Han Yeon Joo Lee Young-jae Cho Jong Sun Park Ho Il Yoon Choon-Taek Lee Jae Ho Lee Prognosis of nontuberculous mycobacterial pulmonary disease according to the method of microbiologic diagnosis
description	Abstract Microbiological criteria for nontuberculous mycobacterial pulmonary disease (NTM-PD) require cultures from two separate sputum or one non-sputum specimen. However, there is limited data on the progression of NTM-PD following non-sputum culture-based diagnosis. We compared the disease progression of NTM-PD diagnosed with non-sputum vs sputum cultures. We included 833 patients and divided them into sputum NTM isolation (n = 123), sputum NTM-PD (n = 558), and non-sputum NTM-PD groups (n = 152). Disease progression, defined as radiographic aggravation and therapy initiation, was compared between groups. The median observation time was 60.5 months (interquartile range, 31.4–96.0). The non-sputum NTM-PD group showed longer treatment-free survival (log-rank test; p = 0.009) and lower risk of treatment (adjusted hazard ratio [aHR] of sputum NTM-PD group, 1.36; 95% confidence interval (CI), 1.01–1.84) than the sputum NTM-PD group. The non-sputum NTM-PD group showed longer radiographic aggravation-free survival (Log-rank test; p = 0.015) and lower risk of radiographic aggravation (aHR of sputum NTM-PD group, 1.52; 95% CI, 1.06–2.19) than the sputum NTM-PD group. NTM-PD diagnosed using methods other than sputum culture showed a low risk of disease progression and progressed slower than NTM-PD diagnosed from a sputum culture. NTM-PD diagnosed using methods other than sputum culture may be a mild disease, not equivalent to NTM-PD diagnosed from sputum culture.
format	article
author	Sooim Sin Seungchul Han Yeon Joo Lee Young-jae Cho Jong Sun Park Ho Il Yoon Choon-Taek Lee Jae Ho Lee
author_facet	Sooim Sin Seungchul Han Yeon Joo Lee Young-jae Cho Jong Sun Park Ho Il Yoon Choon-Taek Lee Jae Ho Lee
author_sort	Sooim Sin
title	Prognosis of nontuberculous mycobacterial pulmonary disease according to the method of microbiologic diagnosis
title_short	Prognosis of nontuberculous mycobacterial pulmonary disease according to the method of microbiologic diagnosis
title_full	Prognosis of nontuberculous mycobacterial pulmonary disease according to the method of microbiologic diagnosis
title_fullStr	Prognosis of nontuberculous mycobacterial pulmonary disease according to the method of microbiologic diagnosis
title_full_unstemmed	Prognosis of nontuberculous mycobacterial pulmonary disease according to the method of microbiologic diagnosis
title_sort	prognosis of nontuberculous mycobacterial pulmonary disease according to the method of microbiologic diagnosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9d9f1ac4372b42039d44283506774fb1
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Prognosis of nontuberculous mycobacterial pulmonary disease according to the method of microbiologic diagnosis

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