Synergistic broad-spectrum antibacterial activity of Hypoxis hemerocallidea-derived silver nanoparticles and streptomycin against respiratory pathobionts

Abstract Respiratory tract infections arise due to the introduction of microbes into the airway, disrupting the normal, healthy, complex interdependent microbiome. The selective disruption of this community can be either beneficial or dangerous. Nanoparticles are a potential tool for modifying this...

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Autores principales:	Oluwole S. Aremu, T. Qwebani-Ogunleye, Lebogang Katata-Seru, Zimbili Mkhize, John F. Trant
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9da6ae86ddb54544bad8dfd79f4194b0
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spelling	oai:doaj.org-article:9da6ae86ddb54544bad8dfd79f4194b02021-12-02T16:06:44ZSynergistic broad-spectrum antibacterial activity of Hypoxis hemerocallidea-derived silver nanoparticles and streptomycin against respiratory pathobionts10.1038/s41598-021-93978-z2045-2322https://doaj.org/article/9da6ae86ddb54544bad8dfd79f4194b02021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93978-zhttps://doaj.org/toc/2045-2322Abstract Respiratory tract infections arise due to the introduction of microbes into the airway, disrupting the normal, healthy, complex interdependent microbiome. The selective disruption of this community can be either beneficial or dangerous. Nanoparticles are a potential tool for modifying this population. Coated silver nanoparticles (AgNPs) were synthesized using ethanolic extracts of Hypoxis hemerocallidea (EEHH), a Southern African plant used extensively in traditional medicine and the source of many bioactive secondary metabolites. The room temperature reaction between silver nitrate and EEHH forms largely spherical AgNPs with an average diameter of 6–20 nm. These nanoparticles show similar levels of antibacterial activity as the broad-spectrum antibiotic streptomycin against Bacillus cereus, Streptococcus pneumonia, Escherichia coli, Pseudomonas aeuroginosa, and Moraxella catarrhalis. However, the AgNPs synergistically increase the antibacterial activity of streptomycin when they are applied in combination (30–52%). AgNPs are reiterated to be promising dual-function antibiotics, synergistically enhancing activity while also acting as delivery agents for small molecules.Oluwole S. AremuT. Qwebani-OgunleyeLebogang Katata-SeruZimbili MkhizeJohn F. TrantNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Oluwole S. Aremu T. Qwebani-Ogunleye Lebogang Katata-Seru Zimbili Mkhize John F. Trant Synergistic broad-spectrum antibacterial activity of Hypoxis hemerocallidea-derived silver nanoparticles and streptomycin against respiratory pathobionts
description	Abstract Respiratory tract infections arise due to the introduction of microbes into the airway, disrupting the normal, healthy, complex interdependent microbiome. The selective disruption of this community can be either beneficial or dangerous. Nanoparticles are a potential tool for modifying this population. Coated silver nanoparticles (AgNPs) were synthesized using ethanolic extracts of Hypoxis hemerocallidea (EEHH), a Southern African plant used extensively in traditional medicine and the source of many bioactive secondary metabolites. The room temperature reaction between silver nitrate and EEHH forms largely spherical AgNPs with an average diameter of 6–20 nm. These nanoparticles show similar levels of antibacterial activity as the broad-spectrum antibiotic streptomycin against Bacillus cereus, Streptococcus pneumonia, Escherichia coli, Pseudomonas aeuroginosa, and Moraxella catarrhalis. However, the AgNPs synergistically increase the antibacterial activity of streptomycin when they are applied in combination (30–52%). AgNPs are reiterated to be promising dual-function antibiotics, synergistically enhancing activity while also acting as delivery agents for small molecules.
format	article
author	Oluwole S. Aremu T. Qwebani-Ogunleye Lebogang Katata-Seru Zimbili Mkhize John F. Trant
author_facet	Oluwole S. Aremu T. Qwebani-Ogunleye Lebogang Katata-Seru Zimbili Mkhize John F. Trant
author_sort	Oluwole S. Aremu
title	Synergistic broad-spectrum antibacterial activity of Hypoxis hemerocallidea-derived silver nanoparticles and streptomycin against respiratory pathobionts
title_short	Synergistic broad-spectrum antibacterial activity of Hypoxis hemerocallidea-derived silver nanoparticles and streptomycin against respiratory pathobionts
title_full	Synergistic broad-spectrum antibacterial activity of Hypoxis hemerocallidea-derived silver nanoparticles and streptomycin against respiratory pathobionts
title_fullStr	Synergistic broad-spectrum antibacterial activity of Hypoxis hemerocallidea-derived silver nanoparticles and streptomycin against respiratory pathobionts
title_full_unstemmed	Synergistic broad-spectrum antibacterial activity of Hypoxis hemerocallidea-derived silver nanoparticles and streptomycin against respiratory pathobionts
title_sort	synergistic broad-spectrum antibacterial activity of hypoxis hemerocallidea-derived silver nanoparticles and streptomycin against respiratory pathobionts
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9da6ae86ddb54544bad8dfd79f4194b0
work_keys_str_mv	AT oluwolesaremu synergisticbroadspectrumantibacterialactivityofhypoxishemerocallideaderivedsilvernanoparticlesandstreptomycinagainstrespiratorypathobionts AT tqwebaniogunleye synergisticbroadspectrumantibacterialactivityofhypoxishemerocallideaderivedsilvernanoparticlesandstreptomycinagainstrespiratorypathobionts AT lebogangkatataseru synergisticbroadspectrumantibacterialactivityofhypoxishemerocallideaderivedsilvernanoparticlesandstreptomycinagainstrespiratorypathobionts AT zimbilimkhize synergisticbroadspectrumantibacterialactivityofhypoxishemerocallideaderivedsilvernanoparticlesandstreptomycinagainstrespiratorypathobionts AT johnftrant synergisticbroadspectrumantibacterialactivityofhypoxishemerocallideaderivedsilvernanoparticlesandstreptomycinagainstrespiratorypathobionts
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Synergistic broad-spectrum antibacterial activity of Hypoxis hemerocallidea-derived silver nanoparticles and streptomycin against respiratory pathobionts

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