Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects.

Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects.

<h4>Background</h4>The BH3-only protein Bid is an important component of death receptor-mediated caspase activation. Bid is cleaved by caspase-8 or -10 into t-Bid, which translocates to mitochondria and triggers the release of caspase-activating factors. Bid has also been reported to be...

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Autores principales: Barbara Köhler, Sergio Anguissola, Caoimhin G Concannon, Markus Rehm, Donat Kögel, Jochen H M Prehn
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2008
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/9da79b8556914ac2b4b5a24da8154b09
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