The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury
Spinal cord injury (SCI) is a devasting condition with no reliable treatment. Spina bifida is the most common cause of congenital SCI. Cell-based therapies using mesenchymal stem/stromal cells (MSCS) have been largely utilized in SCI. Several clinical trials for acquired SCI use adult tissue-derived...
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2021
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oai:doaj.org-article:9da9ab8f982c434fbd3aa51b06d65e1b2021-11-25T17:07:45ZThe Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury10.3390/cells101128372073-4409https://doaj.org/article/9da9ab8f982c434fbd3aa51b06d65e1b2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2837https://doaj.org/toc/2073-4409Spinal cord injury (SCI) is a devasting condition with no reliable treatment. Spina bifida is the most common cause of congenital SCI. Cell-based therapies using mesenchymal stem/stromal cells (MSCS) have been largely utilized in SCI. Several clinical trials for acquired SCI use adult tissue-derived MSC sources, including bone-marrow, adipose, and umbilical cord tissues. The first stem/stromal cell clinical trial for spina bifida is currently underway (NCT04652908). The trial uses early gestational placental-derived mesenchymal stem/stromal cells (PMSCs) during the fetal repair of myelomeningocele. PMSCs have been shown to exhibit unique neuroprotective, angiogenic, and antioxidant properties, all which are promising applications for SCI. This review will summarize the unique properties and current applications of PMSCs and discuss their therapeutic role for acquired SCI.Edwin S KulubyaKaitlin ClarkDake HaoSabrina LazarArash Ghaffari-RafiTejas KarnatiJulius Okudu EbinuMarike ZwienenbergDiana L FarmerAijun WangMDPI AGarticlemesenchymal stromal cellsextracellular vesiclesspinal cord injuryspina bifidamyelomeningoceleBiology (General)QH301-705.5ENCells, Vol 10, Iss 2837, p 2837 (2021) |
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DOAJ |
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EN |
| topic |
mesenchymal stromal cells extracellular vesicles spinal cord injury spina bifida myelomeningocele Biology (General) QH301-705.5 |
| spellingShingle |
mesenchymal stromal cells extracellular vesicles spinal cord injury spina bifida myelomeningocele Biology (General) QH301-705.5 Edwin S Kulubya Kaitlin Clark Dake Hao Sabrina Lazar Arash Ghaffari-Rafi Tejas Karnati Julius Okudu Ebinu Marike Zwienenberg Diana L Farmer Aijun Wang The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury |
| description |
Spinal cord injury (SCI) is a devasting condition with no reliable treatment. Spina bifida is the most common cause of congenital SCI. Cell-based therapies using mesenchymal stem/stromal cells (MSCS) have been largely utilized in SCI. Several clinical trials for acquired SCI use adult tissue-derived MSC sources, including bone-marrow, adipose, and umbilical cord tissues. The first stem/stromal cell clinical trial for spina bifida is currently underway (NCT04652908). The trial uses early gestational placental-derived mesenchymal stem/stromal cells (PMSCs) during the fetal repair of myelomeningocele. PMSCs have been shown to exhibit unique neuroprotective, angiogenic, and antioxidant properties, all which are promising applications for SCI. This review will summarize the unique properties and current applications of PMSCs and discuss their therapeutic role for acquired SCI. |
| format |
article |
| author |
Edwin S Kulubya Kaitlin Clark Dake Hao Sabrina Lazar Arash Ghaffari-Rafi Tejas Karnati Julius Okudu Ebinu Marike Zwienenberg Diana L Farmer Aijun Wang |
| author_facet |
Edwin S Kulubya Kaitlin Clark Dake Hao Sabrina Lazar Arash Ghaffari-Rafi Tejas Karnati Julius Okudu Ebinu Marike Zwienenberg Diana L Farmer Aijun Wang |
| author_sort |
Edwin S Kulubya |
| title |
The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury |
| title_short |
The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury |
| title_full |
The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury |
| title_fullStr |
The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury |
| title_full_unstemmed |
The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury |
| title_sort |
unique properties of placental mesenchymal stromal cells: a novel source of therapy for congenital and acquired spinal cord injury |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/9da9ab8f982c434fbd3aa51b06d65e1b |
| work_keys_str_mv |
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