Ethical aspects of gender assignment in ambiguous genitalia - congenital adrenal hyperplasia: a case report

Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder commonly caused by mutation of the CYP21A2 gene, resulting in deficiency of an enzyme required for cortisol synthesis in the adrenal cortex. In 90-95% of cases, the deficient enzyme is 21-hydroxylase (21-OH), with an incidence r...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nur Rochmah, Muhammad Faizi, Adwina Nurlita Kusuma Wardhani
Formato:	article
Lenguaje:	EN
Publicado:	Indonesian Pediatric Society Publishing House 2021
Materias:	ethical approach; congenital adrenal hyperplasia; child; ambiguous genitalia; gender identity Medicine R Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/9dac2396569c420187fcad545c89886f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9dac2396569c420187fcad545c89886f
record_format	dspace
spelling	oai:doaj.org-article:9dac2396569c420187fcad545c89886f2021-11-29T02:29:22ZEthical aspects of gender assignment in ambiguous genitalia - congenital adrenal hyperplasia: a case report0030-93112338-476X10.14238/pi61.6.2021.356-8https://doaj.org/article/9dac2396569c420187fcad545c89886f2021-11-01T00:00:00Zhttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2376https://doaj.org/toc/0030-9311https://doaj.org/toc/2338-476XCongenital adrenal hyperplasia (CAH) is an autosomal recessive disorder commonly caused by mutation of the CYP21A2 gene, resulting in deficiency of an enzyme required for cortisol synthesis in the adrenal cortex. In 90-95% of cases, the deficient enzyme is 21-hydroxylase (21-OH), with an incidence ranging from 1 in 5,000 to 15,000 live births across various ethnic and racial backgrounds. In classical 21-OH deficiency (21-OHD) CAH, excessive androgen exposure in the fetus results in virilization at birth.1 The management of ambiguous genitalia in children with CAH presents a unique and ethically challenging decision-making dilemma for the medical team. Insensitive and poorly informed statements made in the delivery room may cause long-term psychological problems for the families. It is important to refrain from assigning gender until sufficient diagnostic information can be gathered. Parents, as guardians, and the supporting medical team must make decisions on behalf of the child, with the goal of enabling the child to grow into a healthy and happy adult with his or her assigned gender.2,3 We report a case of a child with CAH, focusing on the ethical challenges in management of ambiguous genitalia.Nur RochmahMuhammad FaiziAdwina Nurlita Kusuma WardhaniIndonesian Pediatric Society Publishing Housearticleethical approach; congenital adrenal hyperplasia; child; ambiguous genitalia; gender identityMedicineRPediatricsRJ1-570ENPaediatrica Indonesiana, Vol 61, Iss 6, Pp 356-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ethical approach; congenital adrenal hyperplasia; child; ambiguous genitalia; gender identity Medicine R Pediatrics RJ1-570
spellingShingle	ethical approach; congenital adrenal hyperplasia; child; ambiguous genitalia; gender identity Medicine R Pediatrics RJ1-570 Nur Rochmah Muhammad Faizi Adwina Nurlita Kusuma Wardhani Ethical aspects of gender assignment in ambiguous genitalia - congenital adrenal hyperplasia: a case report
description	Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder commonly caused by mutation of the CYP21A2 gene, resulting in deficiency of an enzyme required for cortisol synthesis in the adrenal cortex. In 90-95% of cases, the deficient enzyme is 21-hydroxylase (21-OH), with an incidence ranging from 1 in 5,000 to 15,000 live births across various ethnic and racial backgrounds. In classical 21-OH deficiency (21-OHD) CAH, excessive androgen exposure in the fetus results in virilization at birth.1 The management of ambiguous genitalia in children with CAH presents a unique and ethically challenging decision-making dilemma for the medical team. Insensitive and poorly informed statements made in the delivery room may cause long-term psychological problems for the families. It is important to refrain from assigning gender until sufficient diagnostic information can be gathered. Parents, as guardians, and the supporting medical team must make decisions on behalf of the child, with the goal of enabling the child to grow into a healthy and happy adult with his or her assigned gender.2,3 We report a case of a child with CAH, focusing on the ethical challenges in management of ambiguous genitalia.
format	article
author	Nur Rochmah Muhammad Faizi Adwina Nurlita Kusuma Wardhani
author_facet	Nur Rochmah Muhammad Faizi Adwina Nurlita Kusuma Wardhani
author_sort	Nur Rochmah
title	Ethical aspects of gender assignment in ambiguous genitalia - congenital adrenal hyperplasia: a case report
title_short	Ethical aspects of gender assignment in ambiguous genitalia - congenital adrenal hyperplasia: a case report
title_full	Ethical aspects of gender assignment in ambiguous genitalia - congenital adrenal hyperplasia: a case report
title_fullStr	Ethical aspects of gender assignment in ambiguous genitalia - congenital adrenal hyperplasia: a case report
title_full_unstemmed	Ethical aspects of gender assignment in ambiguous genitalia - congenital adrenal hyperplasia: a case report
title_sort	ethical aspects of gender assignment in ambiguous genitalia - congenital adrenal hyperplasia: a case report
publisher	Indonesian Pediatric Society Publishing House
publishDate	2021
url	https://doaj.org/article/9dac2396569c420187fcad545c89886f
work_keys_str_mv	AT nurrochmah ethicalaspectsofgenderassignmentinambiguousgenitaliacongenitaladrenalhyperplasiaacasereport AT muhammadfaizi ethicalaspectsofgenderassignmentinambiguousgenitaliacongenitaladrenalhyperplasiaacasereport AT adwinanurlitakusumawardhani ethicalaspectsofgenderassignmentinambiguousgenitaliacongenitaladrenalhyperplasiaacasereport
_version_	1718407662544093184

Ethical aspects of gender assignment in ambiguous genitalia - congenital adrenal hyperplasia: a case report

Ejemplares similares