Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions

Organoids have improved disease modeling. Here, the authors generate human sensorimotor organoids derived from hiPSCs of individuals with ALS. These organoids contain skeletal muscle, sensory and motor neurons as well as astrocytes, microglia, and vasculature and form neuromuscular junctions.

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Autores principales:	João D. Pereira, Daniel M. DuBreuil, Anna-Claire Devlin, Aaron Held, Yechiam Sapir, Eugene Berezovski, James Hawrot, Katherine Dorfman, Vignesh Chander, Brian J. Wainger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9db38ffd5c8547aa9bc606ed08d490ee
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spelling	oai:doaj.org-article:9db38ffd5c8547aa9bc606ed08d490ee2021-12-02T18:49:35ZHuman sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions10.1038/s41467-021-24776-42041-1723https://doaj.org/article/9db38ffd5c8547aa9bc606ed08d490ee2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24776-4https://doaj.org/toc/2041-1723Organoids have improved disease modeling. Here, the authors generate human sensorimotor organoids derived from hiPSCs of individuals with ALS. These organoids contain skeletal muscle, sensory and motor neurons as well as astrocytes, microglia, and vasculature and form neuromuscular junctions.João D. PereiraDaniel M. DuBreuilAnna-Claire DevlinAaron HeldYechiam SapirEugene BerezovskiJames HawrotKatherine DorfmanVignesh ChanderBrian J. WaingerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q João D. Pereira Daniel M. DuBreuil Anna-Claire Devlin Aaron Held Yechiam Sapir Eugene Berezovski James Hawrot Katherine Dorfman Vignesh Chander Brian J. Wainger Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions
description	Organoids have improved disease modeling. Here, the authors generate human sensorimotor organoids derived from hiPSCs of individuals with ALS. These organoids contain skeletal muscle, sensory and motor neurons as well as astrocytes, microglia, and vasculature and form neuromuscular junctions.
format	article
author	João D. Pereira Daniel M. DuBreuil Anna-Claire Devlin Aaron Held Yechiam Sapir Eugene Berezovski James Hawrot Katherine Dorfman Vignesh Chander Brian J. Wainger
author_facet	João D. Pereira Daniel M. DuBreuil Anna-Claire Devlin Aaron Held Yechiam Sapir Eugene Berezovski James Hawrot Katherine Dorfman Vignesh Chander Brian J. Wainger
author_sort	João D. Pereira
title	Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions
title_short	Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions
title_full	Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions
title_fullStr	Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions
title_full_unstemmed	Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions
title_sort	human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9db38ffd5c8547aa9bc606ed08d490ee
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Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions

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