Long-term exposure of human endothelial cells to metformin modulates miRNAs and isomiRs

Long-term exposure of human endothelial cells to metformin modulates miRNAs and isomiRs

Abstract Increasing evidence suggest that the glucose-lowering drug metformin exerts a valuable anti-senescence role. The ability of metformin to affect the biogenesis of selected microRNAs (miRNAs) was recently suggested. MicroRNA isoforms (isomiRs) are distinct variations of miRNA sequences, harbo...

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Autores principales: Angelica Giuliani, Eric Londin, Manuela Ferracin, Emanuela Mensà, Francesco Prattichizzo, Deborah Ramini, Fiorella Marcheselli, Rina Recchioni, Maria Rita Rippo, Massimiliano Bonafè, Isidore Rigoutsos, Fabiola Olivieri, Jacopo Sabbatinelli
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/9db56585c5b24fc0af64d8a7a31bcb9d
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