CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease

Worldwide pandemics of obesity and diabetes prompt an urgent need for new approaches to their prevention and cure. Here the authors present a CRISPR-based strategy that enhances the therapeutic potential of human adipocytes when implanted in obese mice.

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Autores principales:	Emmanouela Tsagkaraki, Sarah M. Nicoloro, Tiffany DeSouza, Javier Solivan-Rivera, Anand Desai, Lawrence M. Lifshitz, Yuefei Shen, Mark Kelly, Adilson Guilherme, Felipe Henriques, Nadia Amrani, Raed Ibraheim, Tomas C. Rodriguez, Kevin Luk, Stacy Maitland, Randall H. Friedline, Lauren Tauer, Xiaodi Hu, Jason K. Kim, Scot A. Wolfe, Erik J. Sontheimer, Silvia Corvera, Michael P. Czech
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9db95209ec9c4296b7f96552abbf9db0
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spelling	oai:doaj.org-article:9db95209ec9c4296b7f96552abbf9db02021-11-28T12:32:12ZCRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease10.1038/s41467-021-27190-y2041-1723https://doaj.org/article/9db95209ec9c4296b7f96552abbf9db02021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27190-yhttps://doaj.org/toc/2041-1723Worldwide pandemics of obesity and diabetes prompt an urgent need for new approaches to their prevention and cure. Here the authors present a CRISPR-based strategy that enhances the therapeutic potential of human adipocytes when implanted in obese mice.Emmanouela TsagkarakiSarah M. NicoloroTiffany DeSouzaJavier Solivan-RiveraAnand DesaiLawrence M. LifshitzYuefei ShenMark KellyAdilson GuilhermeFelipe HenriquesNadia AmraniRaed IbraheimTomas C. RodriguezKevin LukStacy MaitlandRandall H. FriedlineLauren TauerXiaodi HuJason K. KimScot A. WolfeErik J. SontheimerSilvia CorveraMichael P. CzechNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emmanouela Tsagkaraki Sarah M. Nicoloro Tiffany DeSouza Javier Solivan-Rivera Anand Desai Lawrence M. Lifshitz Yuefei Shen Mark Kelly Adilson Guilherme Felipe Henriques Nadia Amrani Raed Ibraheim Tomas C. Rodriguez Kevin Luk Stacy Maitland Randall H. Friedline Lauren Tauer Xiaodi Hu Jason K. Kim Scot A. Wolfe Erik J. Sontheimer Silvia Corvera Michael P. Czech CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease
description	Worldwide pandemics of obesity and diabetes prompt an urgent need for new approaches to their prevention and cure. Here the authors present a CRISPR-based strategy that enhances the therapeutic potential of human adipocytes when implanted in obese mice.
format	article
author	Emmanouela Tsagkaraki Sarah M. Nicoloro Tiffany DeSouza Javier Solivan-Rivera Anand Desai Lawrence M. Lifshitz Yuefei Shen Mark Kelly Adilson Guilherme Felipe Henriques Nadia Amrani Raed Ibraheim Tomas C. Rodriguez Kevin Luk Stacy Maitland Randall H. Friedline Lauren Tauer Xiaodi Hu Jason K. Kim Scot A. Wolfe Erik J. Sontheimer Silvia Corvera Michael P. Czech
author_facet	Emmanouela Tsagkaraki Sarah M. Nicoloro Tiffany DeSouza Javier Solivan-Rivera Anand Desai Lawrence M. Lifshitz Yuefei Shen Mark Kelly Adilson Guilherme Felipe Henriques Nadia Amrani Raed Ibraheim Tomas C. Rodriguez Kevin Luk Stacy Maitland Randall H. Friedline Lauren Tauer Xiaodi Hu Jason K. Kim Scot A. Wolfe Erik J. Sontheimer Silvia Corvera Michael P. Czech
author_sort	Emmanouela Tsagkaraki
title	CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease
title_short	CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease
title_full	CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease
title_fullStr	CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease
title_full_unstemmed	CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease
title_sort	crispr-enhanced human adipocyte browning as cell therapy for metabolic disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9db95209ec9c4296b7f96552abbf9db0
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CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease

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