Towards real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles

Kobi Jakobsohn, Menachem Motiei, Moshe Sinvani, Rachela PopovtzerFaculty of Engineering and Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan, IsraelBackground: One of the critical problems in cancer management is local recurrence of disease. Between 20% and 30% of p...

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Autores principales:	Jakobsohn K, Motiei M, Sinvani M, Popovtzer R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/9dba2864077c413b9830763d44fb89ce
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spelling	oai:doaj.org-article:9dba2864077c413b9830763d44fb89ce2021-12-02T04:33:09ZTowards real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles1176-91141178-2013https://doaj.org/article/9dba2864077c413b9830763d44fb89ce2012-08-01T00:00:00Zhttp://www.dovepress.com/towards-real-time-detection-of-tumor-margins-using-photothermal-imagin-a10835https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Kobi Jakobsohn, Menachem Motiei, Moshe Sinvani, Rachela PopovtzerFaculty of Engineering and Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan, IsraelBackground: One of the critical problems in cancer management is local recurrence of disease. Between 20% and 30% of patients who undergo tumor resection surgery require reoperation due to incomplete excision. Currently, there are no validated methods for intraoperative tumor margin detection. In the present work, we demonstrate the potential use of gold nanoparticles (GNPs) as a novel contrast agent for photothermal molecular imaging of cancer.Methods: Phantoms containing different concentrations of GNPs were irradiated with continuous-wave laser and measured with a thermal imaging camera which detected the temperature field of the irradiated phantoms.Results: The results clearly demonstrate the ability to distinguish between cancerous cells specifically targeted with GNPs and normal cells. This technique, which allows highly sensitive discrimination between adjacent low GNP concentrations, will allow tumor margin detection while the temperature increases by only a few degrees Celsius (for GNPs in relevant biological concentrations).Conclusion: We expect this real-time intraoperative imaging technique to assist surgeons in determining clear tumor margins and to maximize the extent of tumor resection while sparing normal background tissue.Keywords: photothermal imaging, gold nanoparticles, molecular imagingJakobsohn KMotiei MSinvani MPopovtzer RDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 4707-4713 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jakobsohn K Motiei M Sinvani M Popovtzer R Towards real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles
description	Kobi Jakobsohn, Menachem Motiei, Moshe Sinvani, Rachela PopovtzerFaculty of Engineering and Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan, IsraelBackground: One of the critical problems in cancer management is local recurrence of disease. Between 20% and 30% of patients who undergo tumor resection surgery require reoperation due to incomplete excision. Currently, there are no validated methods for intraoperative tumor margin detection. In the present work, we demonstrate the potential use of gold nanoparticles (GNPs) as a novel contrast agent for photothermal molecular imaging of cancer.Methods: Phantoms containing different concentrations of GNPs were irradiated with continuous-wave laser and measured with a thermal imaging camera which detected the temperature field of the irradiated phantoms.Results: The results clearly demonstrate the ability to distinguish between cancerous cells specifically targeted with GNPs and normal cells. This technique, which allows highly sensitive discrimination between adjacent low GNP concentrations, will allow tumor margin detection while the temperature increases by only a few degrees Celsius (for GNPs in relevant biological concentrations).Conclusion: We expect this real-time intraoperative imaging technique to assist surgeons in determining clear tumor margins and to maximize the extent of tumor resection while sparing normal background tissue.Keywords: photothermal imaging, gold nanoparticles, molecular imaging
format	article
author	Jakobsohn K Motiei M Sinvani M Popovtzer R
author_facet	Jakobsohn K Motiei M Sinvani M Popovtzer R
author_sort	Jakobsohn K
title	Towards real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles
title_short	Towards real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles
title_full	Towards real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles
title_fullStr	Towards real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles
title_full_unstemmed	Towards real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles
title_sort	towards real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/9dba2864077c413b9830763d44fb89ce
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Towards real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles

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