STK39 enhances the progression of Cholangiocarcinoma via PI3K/AKT pathway

Summary: Serine/threonine kinase 39 (STK39) is overexpressed in various tumor tissues and plays an essential role in tumor progression. In this study, we investigated the clinical value, as well as the potential functions and mechanisms of STK39 in cholangiocarcinoma (CCA). The results showed that S...

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Autores principales:	Xiaopei Hao, Yao Zhang, Yiwei Lu, Guoyong Han, Dawei Rong, Guoqiang Sun, Guangshun Sun, Weiwei Tang, Jindao Wu, Xuehao Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Biological sciences Cancer Molecular biology Science Q
Acceso en línea:	https://doaj.org/article/9dbaa665942a436bbb528e64f99d4966
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spelling	oai:doaj.org-article:9dbaa665942a436bbb528e64f99d49662021-11-20T05:08:27ZSTK39 enhances the progression of Cholangiocarcinoma via PI3K/AKT pathway2589-004210.1016/j.isci.2021.103223https://doaj.org/article/9dbaa665942a436bbb528e64f99d49662021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221011913https://doaj.org/toc/2589-0042Summary: Serine/threonine kinase 39 (STK39) is overexpressed in various tumor tissues and plays an essential role in tumor progression. In this study, we investigated the clinical value, as well as the potential functions and mechanisms of STK39 in cholangiocarcinoma (CCA). The results showed that STK39 was overexpressed in CCA and negatively associated with the prognosis of patients with CCA. Functionally, STK39 knockdown suppressed cell proliferation, migration, and invasion, while STK39 overexpression facilitated tumor aggressiveness. The tumor-promoting effects of STK39 in CCA were also validated by in vivo experiments. Mechanistically, RNA-seq analysis identified that STK39 enhanced the progression of CCA by activating PI3K/AKT signaling pathway. Furthermore, overexpression of STK39 could induce gemcitabine resistance in CCA cells. Moreover, the increased expression of STK39 may be mediated by the dysregulation of miR-26a-5p. In summary, STK39 could be served as a valuable prognostic candidate and a potential therapeutic target of CCA.Xiaopei HaoYao ZhangYiwei LuGuoyong HanDawei RongGuoqiang SunGuangshun SunWeiwei TangJindao WuXuehao WangElsevierarticleBiological sciencesCancerMolecular biologyScienceQENiScience, Vol 24, Iss 11, Pp 103223- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biological sciences Cancer Molecular biology Science Q
spellingShingle	Biological sciences Cancer Molecular biology Science Q Xiaopei Hao Yao Zhang Yiwei Lu Guoyong Han Dawei Rong Guoqiang Sun Guangshun Sun Weiwei Tang Jindao Wu Xuehao Wang STK39 enhances the progression of Cholangiocarcinoma via PI3K/AKT pathway
description	Summary: Serine/threonine kinase 39 (STK39) is overexpressed in various tumor tissues and plays an essential role in tumor progression. In this study, we investigated the clinical value, as well as the potential functions and mechanisms of STK39 in cholangiocarcinoma (CCA). The results showed that STK39 was overexpressed in CCA and negatively associated with the prognosis of patients with CCA. Functionally, STK39 knockdown suppressed cell proliferation, migration, and invasion, while STK39 overexpression facilitated tumor aggressiveness. The tumor-promoting effects of STK39 in CCA were also validated by in vivo experiments. Mechanistically, RNA-seq analysis identified that STK39 enhanced the progression of CCA by activating PI3K/AKT signaling pathway. Furthermore, overexpression of STK39 could induce gemcitabine resistance in CCA cells. Moreover, the increased expression of STK39 may be mediated by the dysregulation of miR-26a-5p. In summary, STK39 could be served as a valuable prognostic candidate and a potential therapeutic target of CCA.
format	article
author	Xiaopei Hao Yao Zhang Yiwei Lu Guoyong Han Dawei Rong Guoqiang Sun Guangshun Sun Weiwei Tang Jindao Wu Xuehao Wang
author_facet	Xiaopei Hao Yao Zhang Yiwei Lu Guoyong Han Dawei Rong Guoqiang Sun Guangshun Sun Weiwei Tang Jindao Wu Xuehao Wang
author_sort	Xiaopei Hao
title	STK39 enhances the progression of Cholangiocarcinoma via PI3K/AKT pathway
title_short	STK39 enhances the progression of Cholangiocarcinoma via PI3K/AKT pathway
title_full	STK39 enhances the progression of Cholangiocarcinoma via PI3K/AKT pathway
title_fullStr	STK39 enhances the progression of Cholangiocarcinoma via PI3K/AKT pathway
title_full_unstemmed	STK39 enhances the progression of Cholangiocarcinoma via PI3K/AKT pathway
title_sort	stk39 enhances the progression of cholangiocarcinoma via pi3k/akt pathway
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/9dbaa665942a436bbb528e64f99d4966
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STK39 enhances the progression of Cholangiocarcinoma via PI3K/AKT pathway

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