Genomic Features of Salmonella enterica Subspecies houtenae Serotype 45:g,z51:- Isolated from Multiple Abdominal Abscesses of an African Fat-Tailed Gecko, United States, 2020

Salmonella enterica subsp. houtenae (S. houtenae) is a common subspecies in reptiles and has been implicated as a source of serious and life-threatening diseases in humans. Although occurrence and significance of S. houtenae...

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Autores principales:	Ji-Yeon Hyeon, Zeinab H. Helal, Robert Polkowski, Kristin Vyhnal, Neha Mishra, Junwon Kim, Guillermo R. Risatti, Dong-Hun Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Salmonella enterica</i> subspecies <i>houtenae</i> reptile African fat-tailed gecko complete genome sequence whole genome sequencing Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/9dbad9c28aff46b19eee4e0b9cd4117d
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spelling	oai:doaj.org-article:9dbad9c28aff46b19eee4e0b9cd4117d2021-11-25T16:22:49ZGenomic Features of <i>Salmonella enterica</i> Subspecies <i>houtenae</i> Serotype 45:g,z51:- Isolated from Multiple Abdominal Abscesses of an African Fat-Tailed Gecko, United States, 202010.3390/antibiotics101113222079-6382https://doaj.org/article/9dbad9c28aff46b19eee4e0b9cd4117d2021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1322https://doaj.org/toc/2079-6382<i>Salmonella enterica</i> subsp. <i>houtenae</i> (<i>S. houtenae</i>) is a common subspecies in reptiles and has been implicated as a source of serious and life-threatening diseases in humans. Although occurrence and significance of <i>S. houtenae</i> infections have been extensively studied, the genetic features of <i>S. houtenae</i> have remained unknown due to a lack of available high-quality genome sequences. We obtained the complete genome sequence of <i>S. houtenae</i> 45:g,z51:- strain 20-369 isolated from multiple abdominal abscesses of an African fat-tailed gecko (<i>Hemitheconyx caudicinctus</i>) using Nanopore and Illumina sequencing technologies and generated the 4.65Mbp complete genome sequence of the <i>S. houtenae</i> str. 20-369. We annotated and analyzed the genome sequence with the aim to gain a deeper understanding of the genome characteristics associated with its pathogenicity. Overall, this study found several interesting genomic features such as pseudogene formation, virulence gene profile, and novel genomic islands. This study provides basis for an understanding possible genetic mechanism underlying pathogenicity of <i>S. houtenae</i> 45:g,z51:- as well as a high-quality genome reference for future comparison studies.Ji-Yeon HyeonZeinab H. HelalRobert PolkowskiKristin VyhnalNeha MishraJunwon KimGuillermo R. RisattiDong-Hun LeeMDPI AGarticle<i>Salmonella enterica</i> subspecies <i>houtenae</i>reptileAfrican fat-tailed geckocomplete genome sequencewhole genome sequencingTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1322, p 1322 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Salmonella enterica</i> subspecies <i>houtenae</i> reptile African fat-tailed gecko complete genome sequence whole genome sequencing Therapeutics. Pharmacology RM1-950
spellingShingle	<i>Salmonella enterica</i> subspecies <i>houtenae</i> reptile African fat-tailed gecko complete genome sequence whole genome sequencing Therapeutics. Pharmacology RM1-950 Ji-Yeon Hyeon Zeinab H. Helal Robert Polkowski Kristin Vyhnal Neha Mishra Junwon Kim Guillermo R. Risatti Dong-Hun Lee Genomic Features of <i>Salmonella enterica</i> Subspecies <i>houtenae</i> Serotype 45:g,z51:- Isolated from Multiple Abdominal Abscesses of an African Fat-Tailed Gecko, United States, 2020
description	<i>Salmonella enterica</i> subsp. <i>houtenae</i> (<i>S. houtenae</i>) is a common subspecies in reptiles and has been implicated as a source of serious and life-threatening diseases in humans. Although occurrence and significance of <i>S. houtenae</i> infections have been extensively studied, the genetic features of <i>S. houtenae</i> have remained unknown due to a lack of available high-quality genome sequences. We obtained the complete genome sequence of <i>S. houtenae</i> 45:g,z51:- strain 20-369 isolated from multiple abdominal abscesses of an African fat-tailed gecko (<i>Hemitheconyx caudicinctus</i>) using Nanopore and Illumina sequencing technologies and generated the 4.65Mbp complete genome sequence of the <i>S. houtenae</i> str. 20-369. We annotated and analyzed the genome sequence with the aim to gain a deeper understanding of the genome characteristics associated with its pathogenicity. Overall, this study found several interesting genomic features such as pseudogene formation, virulence gene profile, and novel genomic islands. This study provides basis for an understanding possible genetic mechanism underlying pathogenicity of <i>S. houtenae</i> 45:g,z51:- as well as a high-quality genome reference for future comparison studies.
format	article
author	Ji-Yeon Hyeon Zeinab H. Helal Robert Polkowski Kristin Vyhnal Neha Mishra Junwon Kim Guillermo R. Risatti Dong-Hun Lee
author_facet	Ji-Yeon Hyeon Zeinab H. Helal Robert Polkowski Kristin Vyhnal Neha Mishra Junwon Kim Guillermo R. Risatti Dong-Hun Lee
author_sort	Ji-Yeon Hyeon
title	Genomic Features of <i>Salmonella enterica</i> Subspecies <i>houtenae</i> Serotype 45:g,z51:- Isolated from Multiple Abdominal Abscesses of an African Fat-Tailed Gecko, United States, 2020
title_short	Genomic Features of <i>Salmonella enterica</i> Subspecies <i>houtenae</i> Serotype 45:g,z51:- Isolated from Multiple Abdominal Abscesses of an African Fat-Tailed Gecko, United States, 2020
title_full	Genomic Features of <i>Salmonella enterica</i> Subspecies <i>houtenae</i> Serotype 45:g,z51:- Isolated from Multiple Abdominal Abscesses of an African Fat-Tailed Gecko, United States, 2020
title_fullStr	Genomic Features of <i>Salmonella enterica</i> Subspecies <i>houtenae</i> Serotype 45:g,z51:- Isolated from Multiple Abdominal Abscesses of an African Fat-Tailed Gecko, United States, 2020
title_full_unstemmed	Genomic Features of <i>Salmonella enterica</i> Subspecies <i>houtenae</i> Serotype 45:g,z51:- Isolated from Multiple Abdominal Abscesses of an African Fat-Tailed Gecko, United States, 2020
title_sort	genomic features of <i>salmonella enterica</i> subspecies <i>houtenae</i> serotype 45:g,z51:- isolated from multiple abdominal abscesses of an african fat-tailed gecko, united states, 2020
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9dbad9c28aff46b19eee4e0b9cd4117d
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Genomic Features of <i>Salmonella enterica</i> Subspecies <i>houtenae</i> Serotype 45:g,z51:- Isolated from Multiple Abdominal Abscesses of an African Fat-Tailed Gecko, United States, 2020

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